Shamsabadi, A;
Ren, J;
Chudasama, V;
(2017)
Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N-N linkage.
RSC Avdances
, 7
(44)
pp. 27608-27611.
10.1039/c7ra04178k.
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Abstract
Herein we report the one-pot transformation of readily synthesised/easily accessed acyl hydrazides into Nacyl carbamates via an alkylation-elimination reaction sequence. A range of N-acyl carbamates are prepared in consistent yields, including those featuring protecting groups and having alkyl & aryl N-acyl functionality. The reaction conditions also tolerate a wide variety of sensitive functional groups.
| Type: | Article |
|---|---|
| Title: | Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N-N linkage |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c7ra04178k |
| Publisher version: | http://doi.org/10.1039/c7ra04178k |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, C-H ACTIVATION, AMIDE DERIVATIVES, PRODUCTS THEREOF, ALDEHYDES, MILD, ACID, 1,3,4-OXADIAZOLES, HYDROACYLATION, DEPROTECTION, SELECTIVITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1562839 |
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