Maruani, A;
Alom, S;
Canavelli, P;
Lee, MT;
Morgan, RE;
Chudasama, V;
Caddick, S;
(2015)
A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.
Chemical Communications
, 51
(25)
pp. 5279-5282.
10.1039/c4cc08515a.
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Abstract
It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol labelling reagents, which are stable to hydrolysis and thiol exchange.
| Type: | Article |
|---|---|
| Title: | A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c4cc08515a |
| Publisher version: | http://dx.doi.org/10.1039/c4cc08515a |
| Additional information: | This journal is ©The Royal Society of Chemistry 2015. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1457332 |
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