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The use of bromopyridazinedione derivatives in chemical biology

Bahou, Calise; Chudasama, Vijay; (2022) The use of bromopyridazinedione derivatives in chemical biology. Organic & Biomolecular Chemistry 10.1039/d2ob00310d. (In press). Green open access

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Abstract

Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing amount of interest across many avenues of chemical biology as they enable a plethora of therapeutic, imaging and diagnostic applications. Cysteine residues and disulfide bonds have been highlighted as appealing targets for modification due to the highly homogenous nature of the products that can be formed through their site-selective modification. Amongst the reagents available for the site-selective modification of cysteine(s)/disulfide(s), pyridazinediones (PDs) have played a particularly important and enabling role. In this review, we outline the unique chemical features that make PDs especially well-suited to cysteine/disulfide modification on a wide variety of proteins and peptides, as well as provide context as to the problems solved (and applications enabled) by this technology.

Type: Article
Title: The use of bromopyridazinedione derivatives in chemical biology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d2ob00310d
Publisher version: https://doi.org/10.1039/D2OB00310D
Language: English
Additional information: © Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10146807
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