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Dual modification of biomolecules

Maruani, A; Richards, DA; Chudasama, V; (2016) Dual modification of biomolecules. Organic & Biomolecular Chemistry , 14 (26) pp. 6165-6178. 10.1039/c6ob01010e. Green open access

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With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged. Whilst several methods exist for the site-selective introduction of a single chemical moiety, site-selective and bioorthogonal dual modification of biomolecules remains a challenge. The introduction of multiple modules enables a plethora of permutations and combinations and can generate a variety of bioconjuguates with many potential applications. From de novo approaches on oligomers to the post-translational functionalisation of proteins, this review will highlight the main strategies to dually modify biomolecules.

Type: Article
Title: Dual modification of biomolecules
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6ob01010e
Publisher version: http://dx.doi.org/10.1039/c6ob01010e
Language: English
Keywords: science & technology, physical sciences, chemistry, organic, chemistry, chemical protein modification, site-specific conjugation, noncanonical amino-acids, click-chemistry, escherichia-coli, bioorthogonal reactions, cross-linking, genetic-code, single, molecule
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1499873
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