Bahou, C;
Spears, RJ;
Aliev, AE;
Maruani, A;
Fernandez, M;
Javaid, F;
Szijj, PA;
... Chudasama, V; + view all
(2019)
Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.
Chemical Communications
10.1039/c9cc08362f.
(In press).
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Abstract
Herein we report a retro-Michael deconjugation pathway of thiol-pyridazinedione linked protein bioconjugates to provide a novel cleavable linker technology. We demonstrate that the novel pyridazinedione linker does not suffer from off-target modification with blood thiols (e.g., glutathione, human serum albumin (HSA)), which is in sharp contrast to an analogous maleimide linker.
| Type: | Article |
|---|---|
| Title: | Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c9cc08362f |
| Publisher version: | https://doi.org/10.1039/c9cc08362f |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10086930 |
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