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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Smith, ME; Caspersen, MB; Robinson, E; Morais, M; Maruani, A; Nunes, JP; Nicholls, K; ... Chudasama, V; + view all (2015) A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine. Organic and Biomolecular Chemistry , 13 (29) pp. 7946-7949. 10.1039/c5ob01205h. Green open access

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Abstract

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.

Type: Article
Title: A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c5ob01205h
Publisher version: http://dx.doi.org/10.1039/c5ob01205h
Language: English
Additional information: This journal is © The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1474039
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