Spears, RJ;
McMahon, C;
Chudasama, V;
(2021)
Cysteine protecting groups: applications in peptide and protein science.
Chemical Society Reviews
10.1039/d1cs00271f.
(In press).
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Abstract
Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide and protein chemistry over the last several decades. Increasingly sophisticated strategies for the protection, and subsequent deprotection, of cysteine have been developed, facilitating synthesis of complex disulfide-rich peptides, semisynthesis of proteins, and peptide/protein labelling in vitro and in vivo. In this review, we analyse and discuss the 60+ individual protecting groups reported for cysteine, highlighting their applications in peptide synthesis and protein science.
| Type: | Article |
|---|---|
| Title: | Cysteine protecting groups: applications in peptide and protein science |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d1cs00271f |
| Publisher version: | https://doi.org/10.1039/D1CS00271F |
| Language: | English |
| Additional information: | © Royal Society of Chemistry 2021. This article is Open Access (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10133370 |
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