Chudasama, V;
Smith, MEB;
Schumacher, FF;
Papaioannou, D;
Waksman, G;
Baker, JR;
Caddick, S;
(2011)
Bromopyridazinedione-mediated protein and peptide bioconjugation.
Chemical Communications
, 47
(31)
8781 - 8783.
10.1039/c1cc12807h.
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Abstract
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.
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