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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

Nunes, JP; Morais, M; Vassileva, V; Robinson, E; Rajkumar, VS; Smith, ME; Pedley, RB; ... Chudasama, V; + view all (2015) Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC). Chemical Communications , 51 (53) pp. 10624-10627. 10.1039/c5cc03557k. Green open access

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Abstract

Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.

Type: Article
Title: Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c5cc03557k
Publisher version: http://dx.doi.org/10.1039/c5cc03557k
Additional information: This journal is ©The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1474090
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