Nunes, JP;
Morais, M;
Vassileva, V;
Robinson, E;
Rajkumar, VS;
Smith, ME;
Pedley, RB;
... Chudasama, V; + view all
(2015)
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC).
Chemical Communications
, 51
(53)
pp. 10624-10627.
10.1039/c5cc03557k.
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Abstract
Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.
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