Ahmed, N;
Shamsabadi, A;
Chudasama, V;
(2019)
Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides.
ACS Omega
, 4
(27)
pp. 22602-22612.
10.1021/acsomega.9b03417.
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Abstract
Herein, we report the transformation of readily accessed acyl hydrazides into protected 2-aminobenzophenones via a two-step process involving an aryne-based molecular rearrangement followed by a one-pot addition-elimination procedure. The assembly of the scaffold is tolerant of a wide variety of functional groups, and the carbamate group on the product can be facilely removed to afford highly valuable 2-aminobenzophenones. Application of the protocol was demonstrated in the synthesis of neurological medicine phenazepam.
| Type: | Article |
|---|---|
| Title: | Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsomega.9b03417 |
| Publisher version: | https://doi.org/10.1021/acsomega.9b03417 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088597 |
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