Lee, MTW;
Maruani, A;
Richards, DA;
Baker, JR;
Caddick, S;
Chudasama, V;
(2017)
Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering.
Chemical Science
, 8
(3)
pp. 2056-2060.
10.1039/c6sc03655d.
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Abstract
The generation of antibody conjugates with a loading of two modules is desirable for a host of reasons. Whilst certain antibody engineering approaches have been useful in the preparation of such constructs, a reliable method based on a native antibody scaffold without the use of enzymes or harsh oxidative conditions has hitherto not been achieved. The use of native antibodies has several advantages in terms of cost, practicality, accessibility, time and overall efficiency. Herein we present a novel, reliable method of furnishing antibody conjugates with a loading of two modules starting from a native antibody scaffold.
| Type: | Article |
|---|---|
| Title: | Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6sc03655d |
| Publisher version: | http://dx.doi.org/10.1039/C6SC03655D |
| Language: | English |
| Additional information: | Open Access Article. Published on 28 November 2016. Downloaded on 14/03/2017 15:57:04. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1544838 |
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