Ahmed, Nehaal;
Spears, Richard J;
Sheppard, Tom D;
Chudasama, Vijay;
(2022)
Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation.
Chemical Science
10.1039/d2sc01626e.
(In press).
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Abstract
With an ever-growing emphasis on sustainable synthesis, aerobic C–H activation (the use of oxygen in air to activate C–H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers via aerobically generated radical intermediates to form new C–C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C–H activation mechanism.
| Type: | Article |
|---|---|
| Title: | Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d2sc01626e |
| Publisher version: | https://doi.org/10.1039/D2SC01626E |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10151882 |
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