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Number of items: 118.
Article
Acman, M;
Van Dorp, L;
Santini, JM;
Balloux, F;
(2020)
Large-scale network analysis captures biological features of bacterial plasmids.
Nature Communications
, 11
, Article 2452. 10.1038/s41467-020-16282-w.
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Al-Shayeb, B;
Sachdeva, R;
Chen, L-X;
Ward, F;
Munk, P;
Devoto, A;
Castelle, CJ;
... Banfield, JF; + view all
(2020)
Clades of huge phages from across Earth's ecosystems.
Nature
, 578
pp. 425-431.
10.1038/s41586-020-2007-4.
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Allison, TM;
Barran, P;
Benesch, JLP;
Cianferani, S;
Degiacomi, MT;
Gabelica, V;
Grandori, R;
... Thalassinos, K; + view all
(2020)
Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data.
Analytical Chemistry
, 92
(16)
pp. 10881-10890.
10.1021/acs.analchem.9b05792.
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Allison, TM;
Barran, P;
Cianférani, S;
Degiacomi, MT;
Gabelica, V;
Grandori, R;
Marklund, EG;
... Benesch, JLP; + view all
(2020)
Computational Strategies and Challenges for Using Native Ion Mobility Mass Spectrometry in Biophysics and Structural Biology.
Analytical Chemistry
, 92
(16)
pp. 10872-10880.
10.1021/acs.analchem.9b05791.
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ASLAN, ES;
WHITE, KN;
SYED, BA;
SRAI, KS;
EVANS, RW;
(2020)
Expression of soluble, active, fluorescently tagged hephaestin in COS and CHO cell lines.
Turkish Journal of Biology
, 44
(6)
pp. 393-405.
10.3906/biy-2005-39.
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Atherton, J;
Hummel, JJ;
Olieric, N;
Locke, J;
Peña, A;
Rosenfeld, SS;
Steinmetz, MO;
... Moores, CA; + view all
(2020)
The mechanism of kinesin inhibition by kinesin binding protein.
eLife
, 9
, Article e61481. 10.7554/eLife.61481.
(In press).
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Bancroft, PJ;
Turapov, O;
Jagatia, H;
Arnvig, KB;
Mukamolova, GV;
Green, J;
(2020)
Coupling of Peptidoglycan Synthesis to Central Metabolism in Mycobacteria: Post-transcriptional Control of CwlM by Aconitase.
Cell Reports
, 32
(13)
, Article 108209. 10.1016/j.celrep.2020.108209.
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Baxter, M;
Voronkov, M;
Poolman, T;
Galli, G;
Pinali, C;
Goosey, L;
Knight, A;
... Ray, D; + view all
(2020)
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
eLife
, 9
, Article e50705. 10.7554/eLife.50705.
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Bellany, F;
Tsuchiya, Y;
Tran, TM;
Chan, AWE;
Allan, H;
Gout, I;
Tabor, AB;
(2020)
Design and synthesis of Coenzyme A analogues as Aurora kinase A inhibitors: An exploration of the roles of the pyrophosphate and pantetheine moieties.
Bioorganic & Medicinal Chemistry
, 28
(22)
, Article 115740. 10.1016/j.bmc.2020.115740.
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Ben Bdira, F;
Waudby, CA;
Volkov, AN;
Schröder, SP;
AB, E;
Codée, JDC;
Overkleeft, HS;
... Ubbink, M; + view all
(2020)
Dynamics of Ligand Binding to a Rigid Glycosidase.
Angewandte Chemie
10.1002/ange.202003236.
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Blum, M;
Chang, H-Y;
Chuguransky, S;
Grego, T;
Kandasaamy, S;
Mitchell, A;
Nuka, G;
... Finn, RD; + view all
(2020)
The InterPro protein families and domains database: 20 years on.
Nucleic Acids Research
10.1093/nar/gkaa977.
(In press).
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Briant, K;
Redlingshöfer, L;
Brodsky, FM;
(2020)
Clathrin's life beyond 40: Connecting biochemistry with physiology and disease.
Current Opinion in Cell Biology
, 65
pp. 141-149.
10.1016/j.ceb.2020.06.004.
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Britt, HM;
Prakash, AS;
Appleby, S;
Mosely, JA;
Sanderson, JM;
(2020)
Lysis of membrane lipids promoted by small organic molecules: Reactivity depends on structure but not lipophilicity.
Science Advances
, 6
(17)
, Article eaaz8598. 10.1126/sciadv.aaz8598.
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Brodsky, FM;
Parham, P;
(2020)
In Memoriam: Peter Hartmann (1946-2020), publisher, colleague and friend.
HLA: Immune Response Genetics
, 96
(6)
pp. 665-666.
10.1111/tan.14089.
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Brodsky, FM;
Perez, F;
(2020)
Looking back to traffic forward: A tribute to Thomas Kreis (1952‐1998) and his inspiration.
Traffic
, 21
(1)
pp. 186-188.
10.1111/tra.12697.
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Brodsky, FM;
Stow, JL;
(2020)
Editorial overview: Membrane traffic in the time of COVID-19.
Current Opinion in Cell Biology
, 65
iii-v.
10.1016/j.ceb.2020.09.003.
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Bultitude, WP;
Schellekens, J;
Szydlo, RM;
Anthias, C;
Cooley, SA;
Miller, JS;
Weisdorf, DJ;
... Marsh, SGE; + view all
(2020)
Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML.
Bone Marrow Transplantation
, 55
pp. 1975-1984.
10.1038/s41409-020-0858-9.
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Cackett, G;
Matelska, D;
Sýkora, M;
Portugal, R;
Malecki, M;
Bähler, J;
Dixon, L;
(2020)
The African Swine Fever Virus Transcriptome.
Journal of Virology
, 94
(9)
, Article e00119-20. 10.1128/JVI.00119-20.
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Cackett, G;
Sýkora, M;
Werner, F;
(2020)
Transcriptome view of a killer: African swine fever virus.
Biochemical Society Transactions
10.1042/BST20191108.
(In press).
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Capitini, C;
Fani, G;
Vega, MV;
Penco, A;
Canale, C;
Cabrita, LD;
Calamai, M;
... Chiti, F; + view all
(2020)
Full-length TDP-43 and its C-terminal domain form filamentsin vitrohaving non-amyloid properties.
Amyloid
, 28
(1)
pp. 56-65.
10.1080/13506129.2020.1826425.
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Casamento, A;
Boucrot, E;
(2020)
Molecular mechanism of Fast Endophilin-Mediated Endocytosis.
The Biochemical Journal
, 477
(12)
pp. 2327-2345.
10.1042/BCJ20190342.
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Cassaignau, AME;
Cabrita, LD;
Christodoulou, J;
(2020)
How Does the Ribosome Fold the Proteome?
Annual Review of Biochemistry
, 89
pp. 389-415.
10.1146/annurev-biochem-062917-012226.
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Conole, D;
Chou, Y-T;
Patsiarika, A;
Nwabo, V;
Dinnitriou, E;
Soudy, C;
Mota, F;
... Selwood, DL; + view all
(2020)
Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules.
Drug Development Research
, 81
(4)
pp. 491-500.
10.1002/ddr.21641.
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Csibra, E;
Renders, M;
Pinheiro, V;
(2020)
Bacterial cell display as a robust and versatile platform for the engineering of low affinity ligands and enzymes.
ChemBiochem
, 21
(19)
pp. 2844-2853.
10.1002/cbic.202000203.
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Das, S;
Scholes, HM;
Sen, N;
Orengo, C;
(2020)
CATH functional families predict functional sites in proteins.
Bioinformatics
10.1093/bioinformatics/btaa937.
(In press).
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Edinburgh, RM;
Bradley, HE;
Abdullah, N-F;
Robinson, SL;
Chrzanowski-Smith, OJ;
Walhin, J-P;
Joanisse, S;
... Gonzalez, JT; + view all
(2020)
Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.
The Journal of Clinical Endrocrinology & Metabolism
, 105
(3)
pp. 660-676.
10.1210/clinem/dgz104.
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Edwards, SJL;
Santini, JM;
(2020)
Anthroponotic risk of SARS-CoV-2, precautionary mitigation, and outbreak management.
The Lancet Microbe
10.1016/s2666-5247(20)30086-0.
(In press).
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Eldrid, C;
O'Connor, E;
Thalassinos, K;
(2020)
Concentration‐dependent coulombic effects in travelling wave ion mobility spectrometry collision cross section calibration.
Rapid Communications in Mass Spectrometry
, 34
(S4)
, Article e8613. 10.1002/rcm.8613.
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Eldrid, C;
Thalassinos, K;
(2020)
Developments in tandem ion mobility mass spectrometry.
Biochemical Society Transactions
, 48
(6)
pp. 2457-2466.
10.1042/BST20190788.
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Fare, C;
Yuan, L;
Cordon-Preciado, V;
Michels, JJ;
Bearpark, MJ;
Rich, P;
van Thor, JJ;
(2020)
Radical-Triggered Reaction Mechanism of the Green-to-Red Photoconversion of EosFP.
The Journal of Physical Chemistry B
, 124
(36)
pp. 7765-7778.
10.1021/acs.jpcb.0c04587.
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Faull, SV;
Elliston, ELK;
Gooptu, B;
Jagger, AM;
Aldobiyan, I;
Redzej, A;
Badaoui, M;
... Lomas, DA; + view all
(2020)
The structural basis for Z α₁-antitrypsin polymerization in the liver.
Science Advances
, 6
(43)
, Article eabc1370. 10.1126/sciadv.abc1370.
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Giansily‐Blaizot, M;
Rallapalli, PM;
Perkins, SJ;
Kemball‐Cook, G;
Hampshire, DJ;
Gomez, K;
Ludlam, CA;
(2020)
The EAHAD blood coagulation factor VII variant database.
Human Mutation
10.1002/humu.24025.
(In press).
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Gould, GW;
Brodsky, F;
Bryant, NJ;
(2020)
Building GLUT4 vesilces: CHC22 clathrin's human touch.
Trends in Cell Biology
10.1016/j.tcb.2020.05.007.
(In press).
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Gradeci, D;
Bove, A;
Charras, G;
Lowe, AR;
Banerjee, S;
(2020)
Single-cell approaches to cell competition: high-throughput imaging, machine learning and simulations.
Seminars in Cancer Biology
, 63
pp. 60-68.
10.1016/j.semcancer.2019.05.007.
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Greenwood, SOR;
Chan, AWE;
Hansen, DF;
Marson, CM;
(2020)
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit.
Bioorganic & Medicinal Chemistry Letters
, 30
(5)
, Article 126926. 10.1016/j.bmcl.2019.126926.
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Greig, Joshua;
Bulgakova, Natalia A;
(2020)
Interplay between actomyosin and E-cadherin dynamics regulates cell shape in the Drosophila embryonic epidermis.
Journal of Cell Science
, 133
(15)
, Article jcs242321. 10.1242/jcs.242321.
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Gruszka, DT;
Xie, S;
Kimura, H;
Yardimci, H;
(2020)
Single-molecule imaging reveals control of parental histone recycling by free histones during DNA replication.
Science Advances
, 6
(38)
, Article eabc0330. 10.1126/sciadv.abc0330.
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Harris, SE;
Poolman, TM;
Arvaniti, A;
Cox, RD;
Gathercole, LL;
Tomlinson, JW;
(2020)
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
American Journal of Physiology - Gastrointestinal and Liver Physiology
, 319
(3)
G345-G360.
10.1152/ajpgi.00055.2020.
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Hartley, AM;
Meunier, B;
Pinotsis, N;
Maréchal, A;
(2020)
Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Proceedings of the National Academy of Sciences
10.1073/pnas.1920612117.
(In press).
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Heifetz, A;
James, T;
Southey, M;
Morao, I;
Fedorov, DG;
Bodkin, MJ;
Townsend-Nicholson, A;
(2020)
Analyzing GPCR-Ligand Interactions with the Fragment Molecular Orbital (FMO) Method.
Methods in Molecular Biology
, 2114
pp. 163-175.
10.1007/978-1-0716-0282-9_11.
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Heifetz, A;
Morao, I;
Babu, MM;
James, T;
Southey, MWY;
Fedorov, DG;
Aldeghi, M;
... Townsend-Nicholson, A; + view all
(2020)
Characterising Inter-helical Interactions of G Protein-Coupled Receptors with the Fragment Molecular Orbital Method.
Journal of Chemical Theory and Computation
10.1021/acs.jctc.9b01136.
(In press).
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Heifetz, A;
Sladek, V;
Townsend-Nicholson, A;
Fedorov, DG;
(2020)
Characterizing Protein-Protein Interactions with the Fragment Molecular Orbital Method.
Methods in Molecular Biology
, 2114
pp. 187-205.
10.1007/978-1-0716-0282-9_13.
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Heifetz, A;
Townsend-Nicholson, A;
(2020)
Characterizing Rhodopsin-Arrestin Interactions with the Fragment Molecular Orbital (FMO) Method.
Methods in Molecular Biology
, 2114
pp. 177-186.
10.1007/978-1-0716-0282-9_12.
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Hunter, AL;
Pelekanou, CE;
Adamson, A;
Downton, P;
Barron, NJ;
Cornfield, T;
Poolman, TM;
... Ray, DW; + view all
(2020)
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism.
Proceedings of the National Academy of Sciences of the United States of America
10.1073/pnas.2005330117.
(In press).
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Ireland, S;
Martin, A;
(2020)
atomium - A Python structure parser.
Bioinformatics
, 36
(9)
pp. 2750-2754.
10.1093/bioinformatics/btaa072.
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Jagger, AM;
Waudby, CA;
Irving, JA;
Christodoulou, J;
Lomas, DA;
(2020)
High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin.
Nature Communications
, 11
, Article 6371. 10.1038/s41467-020-20147-7.
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Juárez-Jiménez, J;
Gupta, AA;
Karunanithy, G;
Mey, ASJS;
Georgiou, C;
Ioannidis, H;
De Simone, A;
... Michel, J; + view all
(2020)
Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A.
Chemical Science
, 11
(10)
pp. 2670-2680.
10.1039/c9sc04696h.
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Kadkhodayi-Kholghi, N;
Bhatt, JS;
Gor, J;
McDermott, LC;
Gale, DP;
Perkins, SJ;
(2020)
The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.
Journal of Biological Chemistry
, 295
(48)
pp. 16342-16358.
10.1074/jbc.ra120.015132.
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Karunanithy, G;
Reinstein, J;
Hansen, DF;
(2020)
Multi-Quantum Chemical Exchange Saturation Transfer NMR to Quantify Symmetrical Exchange: Application to Rotational Dynamics of the Guanidinium Group in Arginine Side Chains.
The Journal of Physical Chemistry Letters
10.1021/acs.jpclett.0c01322.
(In press).
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Katan, M;
Cockcroft, S;
(2020)
Phospholipase C families: Common themes and versatility in physiology and pathology.
Progress in Lipid Research
, 80
, Article 101065. 10.1016/j.plipres.2020.101065.
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Katan, M;
Cockcroft, S;
(2020)
Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane.
Essays in Biochemistry
, Article EBC20200041. 10.1042/EBC20200041.
(In press).
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Kiataramgul, A;
Maneenin, S;
Purton, S;
Areechon, N;
Hirono, I;
Brocklehurst, TW;
Unajak, S;
(2020)
An oral delivery system for controlling white spot syndrome virus infection in shrimp using transgenic microalgae.
Aquaculture
, 521
, Article 735022. 10.1016/j.aquaculture.2020.735022.
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Kitchen, GB;
Cunningham, PS;
Poolman, TM;
Iqbal, M;
Maidstone, R;
Baxter, M;
Bagnall, J;
... Ray, DW; + view all
(2020)
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
, 117
(3)
pp. 1543-1551.
10.1073/pnas.1915932117.
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Kose, Hazal B;
Xie, Sherry;
Cameron, George;
Strycharska, Melania S;
Yardimci, Hasan;
(2020)
Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase.
Nature Communications
, 11
, Article 3713. 10.1038/s41467-020-17443-7.
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Kramm, K;
Schröder, T;
Gouge, J;
Vera, AM;
Gupta, K;
Heiss, FB;
Liedl, T;
... Grohmann, D; + view all
(2020)
DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability.
Nature Communications
, 11
, Article 2828. 10.1038/s41467-020-16702-x.
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Lam, SD;
Bordin, N;
Waman, VP;
Scholes, HM;
Ashford, P;
Sen, N;
van Dorp, L;
... Orengo, CA; + view all
(2020)
SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.
Scientific Reports
, 10
, Article 16471. 10.1038/s41598-020-71936-5.
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Larrea-Alvarez, M;
Purton, S;
(2020)
Multigenic engineering of the chloroplast genome in the green alga Chlamydomonas reinhardtii.
Microbiology
10.1099/mic.0.000910.
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Laskowski, RA;
Stephenson, JD;
Sillitoe, I;
Orengo, CA;
Thornton, JM;
(2020)
VarSite: disease variants and protein structure.
Protein Science
, 29
(1)
pp. 111-119.
10.1002/pro.3746.
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Leitner, Alexander;
Bonvin, Alexandre MJJ;
Borchers, Christoph H;
Chalkley, Robert J;
Chamot-Rooke, Julia;
Combe, Colin W;
Cox, Jürgen;
... Rappsilber, Juri; + view all
(2020)
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.
Structure
, 28
(11)
pp. 1259-1268.
10.1016/j.str.2020.09.011.
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Lesne, J;
Locard-Paulet, M;
Parra, J;
Zivković, D;
Menneteau, T;
Bousquet, M-P;
Burlet-Schiltz, O;
(2020)
Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks.
Nature Communications
, 11
, Article 6140. 10.1038/s41467-020-19934-z.
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Levray, YS;
Berhe, AD;
Osborne, AR;
(2020)
Use of split-dihydrofolate reductase for the detection of protein-protein interactions and simultaneous selection of multiple plasmids in Plasmodium falciparum.
Molecular and Biochemical Parasitology
, 238
, Article 111292. 10.1016/j.molbiopara.2020.111292.
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Lima, NC;
Atkinson, E;
Bunney, TD;
Katan, M;
Huang, PH;
(2020)
Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.
International Journal of Molecular Sciences
, 21
(9)
, Article 3214. 10.3390/ijms21093214.
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Liu, Y;
Bunney, TD;
Khosa, S;
Macé, K;
Beckenbauer, K;
Askwith, T;
Maslen, S;
... Katan, M; + view all
(2020)
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
EBioMedicine
, 51
, Article 102607. 10.1016/j.ebiom.2019.102607.
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Makrinou, E;
Drong, AW;
Christopoulos, G;
Lerner, A;
Chapa-Chorda, I;
Karaderi, T;
Lavery, S;
... Franks, S; + view all
(2020)
Genome-wide methylation profiling in granulosa lutein cells of women with polycystic ovary syndrome (PCOS).
Molecular and Cellular Endocrinology
, 500
, Article 110611. 10.1016/j.mce.2019.110611.
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Manka, SW;
Moores, CA;
(2020)
Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation.
EMBO Reports
, Article e51534. 10.15252/embr.202051534.
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Maréchal, A;
Xu, J-Y;
Genko, N;
Hartley, AM;
Haraux, F;
Meunier, B;
Rich, PR;
(2020)
A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria.
Proceedings of the National Academy of Sciences
10.1073/pnas.2001572117.
(In press).
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Martin-Nalda, A;
Fortuny, C;
Rey, L;
Bunney, TD;
Alsina, L;
Esteve-Sole, A;
Bull, D;
... Arostegui, J; + view all
(2020)
Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations.
Journal of Clinical Immunology
10.1007/s10875-020-00794-7.
(In press).
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McCarthy, S;
Robinson, J;
Thalassinos, K;
Tabor, AB;
(2020)
A Chemical Biology Approach to Probing the Folding Pathways of the Inhibitory Cystine Knot (ICK) Peptide ProTx-II.
Frontiers in Chemistry
, 8
, Article 228. 10.3389/fchem.2020.00228.
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McVey, JH;
Rallapalli, PM;
Kemball-Cook, G;
Hampshire, DJ;
Giansily-Blaizot, M;
Gomez, K;
Perkins, SJ;
(2020)
The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers.
Haemophilia
, 26
(2)
pp. 306-313.
10.1111/hae.13947.
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Meir, A;
Macé, K;
Lukoyanova, N;
Chetrit, D;
Hospenthal, MK;
Redzej, A;
Roy, C;
(2020)
Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.
Nature Communications
, 11
, Article 2864. 10.1038/s41467-020-16681-z.
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Mitropoulou, AN;
Ceska, T;
Heads, JT;
Beavil, AJ;
Henry, AJ;
McDonnell, JM;
Sutton, BJ;
(2020)
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallographica Section F: Structural Biology Communications
, 76
(3)
pp. 116-129.
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Structure of human RNA polymerase III.
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Proceedings of the National Academy of Sciences
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Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases.
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Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.
Scientific Reports
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CATH: increased structural coverage of functional space.
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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
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HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae.
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Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species.
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SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.
BioRxiv: Cold Spring Harbor, NY, USA.
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Thesis
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Bultitude, Will P.;
(2020)
Generating full-length Killer-cell Immunoglobulin-like Receptor (KIR) gene sequences using Third Generation long-amplicon sequencing to assess the impact of KIR polymorphism on Haematopoietic Cell Transplantation outcomes.
Doctoral thesis (Ph.D), UCL (University College London).
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Kampyli, Charis;
(2020)
Investigation into the cell biological roles of class II PI3K-C2β.
Doctoral thesis (Ph.D), UCL (University College London).
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Siemons, Lucas;
(2020)
Characterising side-chain motions in proteins by Nuclear Magnetic Resonance and Molecular Dynamics to report on function and regulation.
Doctoral thesis (Ph.D), UCL (University College London).
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