UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Clathrin's life beyond 40: Connecting biochemistry with physiology and disease

Briant, K; Redlingshöfer, L; Brodsky, FM; (2020) Clathrin's life beyond 40: Connecting biochemistry with physiology and disease. Current Opinion in Cell Biology , 65 pp. 141-149. 10.1016/j.ceb.2020.06.004. Green open access

[thumbnail of Briant-Redlingshoefer-Brodsky-COCEBI.pdf]
Preview
Text
Briant-Redlingshoefer-Brodsky-COCEBI.pdf - Accepted Version

Download (629kB) | Preview

Abstract

Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways to differentiation, disease and physiological processes such as glucose metabolism are reviewed. Diversity and commonalities of clathrin pathways across the tree of life reveal species-specific differences enabling functional plasticity in both membrane traffic and cytokinesis. New structural information on clathrin coat formation and cargo interactions emphasises the interplay between clathrin, adaptor proteins, lipids and cargo, and how this interplay regulates quality control of clathrin’s function and is compromised in infection and neurological disease. Roles for balancing clathrin-mediated cargo transport are defined in stem cell development and additional disease states.

Type: Article
Title: Clathrin's life beyond 40: Connecting biochemistry with physiology and disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2020.06.004
Publisher version: https://doi.org/10.1016/j.ceb.2020.06.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Clathrin, Clathrin-actin interaction, Clathrin-mediated endocytosis, Clathrin-microtubule interaction, Membrane traffic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10110733
Downloads since deposit
259Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item