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How Does the Ribosome Fold the Proteome?

Cassaignau, AME; Cabrita, LD; Christodoulou, J; (2020) How Does the Ribosome Fold the Proteome? Annual Review of Biochemistry , 89 pp. 389-415. 10.1146/annurev-biochem-062917-012226.

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Abstract

Folding of polypeptides begins during their synthesis on ribosomes. This process has evolved as a means for the cell to maintain proteostasis, by mitigating the risk of protein misfolding and aggregation. The capacity to now depict this cellular feat at increasingly higher resolution is providing insight into the mechanistic determinants that promote successful folding. Emerging from these studies is the intimate interplay between protein translation and folding, and within this the ribosome particle is the key player. Its unique structural properties provide a specialized scaffold against which nascent polypeptides can begin to form structure in a highly coordinated, co-translational manner. Here, we examine how, as a macromolecular machine, the ribosome modulates the intrinsic dynamic properties of emerging nascent polypeptide chains and guides them toward their biologically active structures.

Type: Article
Title: How Does the Ribosome Fold the Proteome?
Location: United States
DOI: 10.1146/annurev-biochem-062917-012226
Publisher version: https://doi.org/10.1146/annurev-biochem-062917-012...
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: co-translational folding, protein synthesis, ribosome-bound nascent chain, protein folding, structural biology, NMR spectroscopy, protein misfolding
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10110724
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