UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

Katan, M; Cockcroft, S; (2020) Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane. Essays in Biochemistry , Article EBC20200041. 10.1042/EBC20200041. (In press). Green open access

[thumbnail of ebc-2020-0041c.pdf]
Preview
Text
ebc-2020-0041c.pdf - Published Version

Download (2MB) | Preview

Abstract

Phosphatidylinositol(4,5) bisphosphate (PI(4,5)P_{2}) has become a major focus in biochemistry, cell biology and physiology owing to its diverse functions at the plasma membrane. As a result, the functions of PI(4,5)P_{2} can be explored in two separate and distinct roles - as a substrate for phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) and as a primary messenger, each having unique properties. Thus PI(4,5)P2 makes contributions in both signal transduction and cellular processes including actin cytoskeleton dynamics, membrane dynamics and ion channel regulation. Signalling through plasma membrane G-protein coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and immune receptors all use PI(4,5)P_{2} as a substrate to make second messengers. Activation of PI3K generates PI(3,4,5)P_{3} (phosphatidylinositol(3,4,5)trisphosphate), a lipid that recruits a plethora of proteins with pleckstrin homology (PH) domains to the plasma membrane to regulate multiple aspects of cellular function. In contrast, PLC activation results in the hydrolysis of PI(4,5)P_{2} to generate the second messengers, diacylglycerol (DAG), an activator of protein kinase C and inositol(1,4,5)trisphosphate (IP_{3}/I(1,4,5)P_{3}) which facilitates an increase in intracellular Ca^{2+}. Decreases in PI(4,5)P_{2} by PLC also impact on functions that are dependent on the intact lipid and therefore endocytosis, actin dynamics and ion channel regulation are subject to control. Spatial organisation of PI(4,5)P_{2} in nanodomains at the membrane allows for these multiple processes to occur concurrently.

Type: Article
Title: Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/EBC20200041
Publisher version: https://doi.org/10.1042/EBC20200041
Language: English
Additional information: © 2020 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/).
Keywords: endocytosis, exocytosis, phosphatidylinositol, phospholipases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10109501
Downloads since deposit
96Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item