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Developments in tandem ion mobility mass spectrometry

Eldrid, C; Thalassinos, K; (2020) Developments in tandem ion mobility mass spectrometry. Biochemical Society Transactions , 48 (6) pp. 2457-2466. 10.1042/BST20190788. Green open access

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Abstract

Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which employ tandem IM are less so with the first commercial IM-MS instrument capable of multiple IM selection rounds being released in 2019. Here we explore the history of tandem IM instruments, recent developments, the applications to biological systems and expected future directions.

Type: Article
Title: Developments in tandem ion mobility mass spectrometry
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BST20190788
Publisher version: https://doi.org/10.1042/BST20190788
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: ion mobility, mass spectrometry, protein structure, tandem ion mobility
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10118348
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