UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Klotho and the Treatment of Human Malignancies

Sachdeva, A; Gouge, J; Kontovounisios, C; Nikolaou, S; Ashworth, A; Lim, K; Chong, I; (2020) Klotho and the Treatment of Human Malignancies. Cancers , 12 (6) , Article 1665. 10.3390/cancers12061665. Green open access

[thumbnail of cancers-12-01665.pdf]
Preview
Text
cancers-12-01665.pdf - Published Version

Download (2MB) | Preview

Abstract

Klotho was first discovered as an anti-ageing protein linked to a number of age-related disease processes, including cardiovascular, renal, musculoskeletal, and neurodegenerative conditions. Emerging research has also demonstrated a potential therapeutic role for Klotho in cancer biology, which is perhaps unsurprising given that cancer and ageing share similar molecular hallmarks. In addition to functioning as a tumour suppressor in numerous solid tumours and haematological malignancies, Klotho represents a candidate therapeutic target for patients with these diseases, the majority of whom have limited treatment options. Here, we examine contemporary evidence evaluating the anti-neoplastic effects of Klotho and describe the modulation of downstream oncogenic signalling pathways, including Wnt/β-catenin, FGF, IGF1, PIK3K/AKT, TGFβ, and the Unfolded Protein Response. We also discuss possible approaches to developing therapeutic Klotho and consider technological advances that may facilitate the delivery of Klotho through gene therapy.

Type: Article
Title: Klotho and the Treatment of Human Malignancies
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cancers12061665
Publisher version: https://doi.org/10.3390/cancers12061665
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Klotho, cancer, colorectal cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10105197
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item