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Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis

Roddan, R; Ward, JM; Keep, NH; Hailes, HC; (2020) Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis. Current Opinion in Chemical Biology , 55 pp. 69-76. 10.1016/j.cbpa.2019.12.003. Green open access

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Abstract

Pictet–Spenglerases provide a key role in the biosynthesis of many biologically active alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic synthetic methods as they provide stereoselective and regioselective control under mild conditions. Products from these enzymes also contain privileged drug scaffolds (such as tetrahydroisoquinoline or β-carboline moieties), so there is interest in the characterization and use of these enzymes as versatile biocatalysts to synthesize analogs of the corresponding natural products for drug discovery. This review discusses all known Pictet–Spenglerase enzymes and their applications as biocatalysts.

Type: Article
Title: Pictet–Spenglerases in alkaloid biosynthesis: Future applications in biocatalysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cbpa.2019.12.003
Publisher version: https://doi.org/10.1016/j.cbpa.2019.12.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biocatalysis, Pictet–Spengler, Alkaloid, Biosynthesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10090140
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