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Building GLUT4 vesilces: CHC22 clathrin's human touch

Gould, GW; Brodsky, F; Bryant, NJ; (2020) Building GLUT4 vesilces: CHC22 clathrin's human touch. Trends in Cell Biology 10.1016/j.tcb.2020.05.007. (In press). Green open access

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Abstract

Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent cells have been invaluable in understanding GLUT4 traffic, evolutionary plasticity must be considered when extrapolating these findings to humans. Recent work has identified species-specific distinctions in GLUT4 traffic, notably the participation of a novel clathrin isoform, CHC22, in humans but not rodents. Here, we discuss GLUT4 sorting in different species and how studies of CHC22 have identified new routes for GLUT4 trafficking. We further consider how different sorting-protein complexes relate to these routes and discuss other implications of these pathways in cell biology and disease.

Type: Article
Title: Building GLUT4 vesilces: CHC22 clathrin's human touch
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tcb.2020.05.007
Publisher version: https://doi.org/10.1016/j.tcb.2020.05.007
Language: English
Additional information: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: GLUT4, insulin, CHC22 clathrin, ERGIC, membrane trafficking, diabetes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10099534
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