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Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

Leitner, Alexander; Bonvin, Alexandre MJJ; Borchers, Christoph H; Chalkley, Robert J; Chamot-Rooke, Julia; Combe, Colin W; Cox, Jürgen; ... Rappsilber, Juri; + view all (2020) Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure , 28 (11) pp. 1259-1268. 10.1016/j.str.2020.09.011. Green open access

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Abstract

Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.

Type: Article
Title: Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.str.2020.09.011
Publisher version: https://doi.org/10.1016/j.str.2020.09.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10172393
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