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Number of items: 78.

Article

Armstrong, A; Horry, K; Cui, T; Hulley, M; Turner, R; Farid, SS; Goldrick, S; (2021) Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products. Journal of Chromatography A , 1639 , Article 461914. 10.1016/j.chroma.2021.461914. Green open access
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Bandyopadhyay, S; Morris, SA; Nesbeth, DN; Bracewell, DG; (2021) Lipid reduction to improve clarification and filterability during primary recovery of intracellular products in yeast lysates using exogenous lipase. Journal of Chemical Technology & Biotechnology , 96 (11) pp. 3166-3174. 10.1002/jctb.6871. Green open access
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Barnes, Benjamin; Caws, Thomas; Thomas, Samantha; Shephard, Alex P; Corteling, Randolph; Hole, Paul; Bracewell, Daniel G; (2022) Investigating heparin affinity chromatography for extracellular vesicle purification and fractionation. Journal of Chromatography A , 1670 , Article 462987. 10.1016/j.chroma.2022.462987. Green open access
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Bracewell, DG; Smith, V; Delahaye, M; Smales, CM; (2021) Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products. Current Opinion in Biotechnology , 71 pp. 98-104. 10.1016/j.copbio.2021.06.026. Green open access
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Bracewell, DG; Francis, R; Smales, CM; (2015) The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control. Biotechnology and Bioengineering , 112 (9) pp. 1727-1737. 10.1002/bit.25628. Green open access
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Burden, CS; Jin, J; Podgornik, A; Bracewell, DG; (2012) A monolith purification process for virus-like particles from yeast homogenate. Journal of Chromatography B , 880 (1) 82 - 89. 10.1016/j.jchromb.2011.10.044. Green open access
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Carrillo Sanchez, Braulio; Hinchliffe, Matthew; Bracewell, Daniel G; (2022) GFP-tagging of extracellular vesicles for rapid process development. Biotechnology Journal , Article e2100583. 10.1002/biot.202100583. (In press). Green open access
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Close, EJ; Salm, JR; Bracewell, DG; Sorensen, E; (2014) A model based approach for identifying robust operating conditions for industrial chromatography with process variability. CHEMICAL ENGINEERING SCIENCE , 116 284 - 295. 10.1016/j.ces.2014.03.010. Green open access
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Close, EJ; Salm, JR; Bracewell, DG; Sorensen, E; (2014) Modelling of industrial biopharmaceutical multicomponent chromatography. CHEMICAL ENGINEERING RESEARCH & DESIGN , 92 (7) 1304 - 1314. 10.1016/j.cherd.2013.10.022. Green open access
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Close, EJ; Salm, JR; Iskra, T; Sørensen, E; Bracewell, DG; (2013) Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies. Biotechnology and Bioengineering , 110 (9) pp. 2425-2435. 10.1002/bit.24898. Green open access
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Colant, N; Melinek, B; Frank, S; Rosenberg, W; Bracewell, DG; (2021) Escherichia Coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles. Vaccines , 9 (3) , Article 193. 10.3390/vaccines9030193. Green open access
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Colant, N; Melinek, B; Teneb, J; Goldrick, S; Rosenberg, W; Frank, S; Bracewell, DG; (2020) A rational approach to improving titer in Escherichia coli‐based cell‐free protein synthesis reactions. Biotechnology Progress , Article e3062. 10.1002/btpr.3062. (In press). Green open access
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Colao, Ivano Luigi; Corteling, Randolph L; Bracewell, Daniel G; Wall, Ivan B; (2025) Neural stem cell–derived extracellular vesicles purified by monolith chromatography retain stimulatory effect in in vitro scratch assay. Cytotherapy , 27 (3) pp. 365-377. 10.1016/j.jcyt.2024.11.007. Green open access
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Colao, IL; Corteling, R; Bracewell, D; Wall, I; (2018) Manufacturing Exosomes: A Promising Therapeutic Platform. Trends in Molecular Medicine , 24 (3) pp. 242-256. 10.1016/j.molmed.2018.01.006. Green open access
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Deuker, D; Asilonu, E; Bracewell, DG; Frank, S; (2024) Adeno-Associated Virus 5 Protein Particles Produced by E. coli Cell-Free Protein Synthesis. ACS Synthetic Biology 10.1021/acssynbio.4c00403. (In press). Green open access
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Dods, SR; Hardick, O; Stevens, B; Bracewell, DG; (2015) Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography. J Chromatogr A , 1376 74 - 83. 10.1016/j.chroma.2014.12.010. Green open access
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Duran-Villalobos, CA; Ogonah, O; Melinek, B; Bracewell, DG; Hallam, T; Lennox, B; (2021) Multivariate statistical data analysis of cell-free protein synthesis toward monitoring and control. AIChE Journal , Article e17257. 10.1002/aic.17257. (In press). Green open access
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Edwards, Elizabeth; Livanos, Maria; Krueger, Anja; Dell, Anne; Haslam, Stuart M; Mark Smales, C; Bracewell, Daniel G; (2022) Strategies to Control Therapeutic Antibody Glycosylation during Bioprocessing: Synthesis and Separation. Biotechnology and Bioengineering , 119 (6) pp. 1343-1358. 10.1002/bit.28066. Green open access
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El-Sabbahy, H; Ward, D; Ogonah, O; Deakin, L; Jellum, GM; Bracewell, DG; (2018) The effect of feed quality due to clarification strategy on the design and performance of protein A periodic counter-current chromatography. Biotechnology Progress , 34 (6) pp. 1380-1392. 10.1002/btpr.2709. Green open access
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Espuny Garcia Del Real, G; Davies, J; Bracewell, DG; (2014) Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development. Biotechnol Bioeng , 111 (12) 2486 - 2498. 10.1002/bit.25313. Green open access
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Fanthom, Thomas B; Wilson, Christopher; Gruber, David; Bracewell, Daniel G; (2023) Solid-Solid Interfacial Contact of Tubing Walls Drives Therapeutic Protein Aggregation During Peristaltic Pumping. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2023.08.012. (In press). Green open access
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Fernández-Castané, A; Li, H; Joseph, S; Ebeler, M; Franzreb, M; Bracewell, DG; Overton, TW; (2021) Nanoparticle tracking analysis as a process analytical tool for characterising magnetosome preparations. Food and Bioproducts Processing , 127 pp. 426-434. 10.1016/j.fbp.2021.03.013. Green open access
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Hardick, O; Dods, S; Stevens, B; Bracewell, DG; (2015) Nanofiber adsorbents for high productivity continuous downstream processing. Journal of Biotechnology , 213 pp. 74-82. 10.1016/j.jbiotec.2015.01.031. Green open access
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Hickey, John M; Jacob, Shaleem I; Tait, Andrew S; Vahid, Fatemeh Dastjerdi; Barritt, Joseph; Rouse, Sarah; Douglas, Alexander; ... Bracewell, Daniel G; + view all (2022) Measurement of Adenovirus-Based Vector Heterogeneity. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2022.12.012. (In press). Green open access
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Husson, G; Delangle, A; O'Hara, J; Cianférani, S; Gervais, A; Van Dorsselaer, A; Bracewell, DG; (2017) Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development. Analytical Chemistry , 90 (2) pp. 1241-1247. 10.1021/acs.analchem.7b03965. Green open access
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Jacob, SI; Konstantinidis, S; Bracewell, DG; (2021) High-Throughput Process Development for the Chromatographic Purification of Viral Antigens. Vaccine Delivery Technology , 2183 pp. 119-182. 10.1007/978-1-0716-0795-4_9. Green open access
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Jasulaityte, G; Johansson, HJ; Bracewell, DG; (2019) Chromatography process development aided by a dye‐based assay. Journal of Chemical Technology & Biotechnology , 95 (1) pp. 132-141. 10.1002/jctb.6214. Green open access
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Johnson, T; Jones, K; Iacoviello, F; Turner, S; Jackson, N; Zourna, K; Welsh, J; ... Bracewell, D; + view all (2021) Liposome Sterile Filtration Characterization via X-ray Computed Tomography and Confocal Microscopy. Membranes , 11 (11) , Article 905. 10.3390/membranes11110905. Green open access
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Johnson, TF; Bailey, JJ; Iacoviello, F; Welsh, JH; Levison, PR; Shearing, PR; Bracewell, DG; (2018) Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy. Journal of Chromatography A , 1566 pp. 79-88. 10.1016/j.chroma.2018.06.054. Green open access
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Johnson, TF; Iacoviello, F; Hayden, DJ; Welsh, JH; Levison, PR; Shearing, PR; Bracewell, DG; (2020) Packed bed compression visualisation and flow simulation using an erosion-dilation approach. Journal of Chromatography A , 1611 , Article 460601. 10.1016/j.chroma.2019.460601. Green open access
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Johnson, TF; Iacoviello, F; Welsh, JH; Shearing, PR; Bracewell, DG; (2021) High-resolution imaging of depth filter structures using X-ray computed tomography. Journal of Materials Science 10.1007/s10853-021-06238-w. (In press). Green open access
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Johnson, TF; Levison, PR; Shearing, PR; Bracewell, DG; (2017) X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis. Journal of Chromatography A , 1487 pp. 108-115. 10.1016/j.chroma.2017.01.013. Green open access
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Lintern, K; Pathak, M; Smales, CM; Howland, K; Rathore, A; Bracewell, DG; (2016) Residual on column host cell protein analysis during lifetime studies of protein A chromatography. Journal of Chromatography A , 1461 pp. 70-77. 10.1016/j.chroma.2016.07.055. Green open access
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Martinez, M; Mannall, G; Spitali, M; Norrant, EL; Bracewell, DG; (2020) Reactor Design for Continuous Monoclonal Antibody Precipitation Based Upon Micro‐mixing. Journal of Chemical Technology & Biotechnology 10.1002/jctb.6652. (In press). Green open access
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Martinez, M; Spitali, M; Norrant, EL; Bracewell, DG; (2019) Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture. Trends in Biotechnology , 37 (3) pp. 237-241. 10.1016/j.tibtech.2018.09.001. Green open access
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Mazzer, AR; Clifton, LA; Perevozchikova, T; Butler, PD; Roberts, CJ; Bracewell, DG; (2017) Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface. Journal of Chromatography A , 1499 pp. 118-131. 10.1016/j.chroma.2017.03.084. Green open access
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Mazzer, AR; Perraud, X; Halley, J; O'Hara, J; Bracewell, DG; (2015) Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold. Journal of Chromatography A , 1415 pp. 83-90. 10.1016/j.chroma.2015.08.068. Green open access
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Melinek, BJ; Dessoy, S; Wright, B; Bracewell, DG; Mukhopadhyay, TK; (2018) Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production. Biotechnology and Bioengineering , 115 (5) pp. 1226-1238. 10.1002/bit.26546. Green open access
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Migani, D; Smales, CM; Bracewell, DG; (2017) Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein (HCP) release in Chinese hamster ovary cells. Biotechnology Progress , 33 (3) pp. 666-676. 10.1002/btpr.2455. Green open access
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Ng, CK; Osuna-Sanchez, H; Valéry, E; Sørensen, E; Bracewell, DG; (2012) Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach. Journal of Chromatography B , 899 116 - 126. 10.1016/j.jchromb.2012.05.010. Green open access
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Noaks, E; Peticone, C; Kotsopoulou, E; Bracewell, DG; (2021) Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing. Molecular Therapy - Methods and Clinical Development , 20 pp. 675-687. 10.1016/j.omtm.2021.02.002. (In press). Green open access
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Nweke, MC; McCartney, RG; Bracewell, DG; (2017) Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture. Journal of Chromatography A , 1530 pp. 129-137. 10.1016/j.chroma.2017.11.038. Green open access
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Nweke, MC; Rathore, AS; Bracewell, DG; (2018) Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture. [Editorial comment]. Trends in Biotechnology , 36 (10) pp. 992-995. 10.1016/j.tibtech.2018.01.001. Green open access
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Nweke, MC; Turmaine, M; McCartney, RG; Bracewell, DG; (2016) Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy. Biotechnology Journal , 12 (3) , Article 1600583. 10.1002/biot.201600583. Green open access
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Ogonah, OW; Polizzi, KM; Bracewell, DG; (2017) Cell free protein synthesis: a viable option for stratified medicines manufacturing? Current Opinion in Chemical Engineering , 18 pp. 77-83. 10.1016/j.coche.2017.10.003. Green open access
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Oh, G; Sirunyan, AM; Tumasyan, A; Adam, W; Ambrogi, F; Asilar, E; Bergauer, T; ... Woods, N; + view all (2019) Beyond nPDFs effects : Prompt J/psi and psi(2S) production in pPb and pp collisions. Nuclear Physics A , 982 pp. 743-746. 10.1016/j.nuclphysa.2018.10.028. Green open access
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Oshinbolu, S; Shah, R; Finka, G; Molloy, M; Uden, M; Bracewell, DG; (2018) Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants. Journal of Chemical Technology and Biotechnology , 93 (3) pp. 909-917. 10.1002/jctb.5519. Green open access
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Oshinbolu, S; Wilson, LJ; Lewis, W; Shah, R; Bracewell, DG; (2018) Measurement of impurities to support process development and manufacture of biopharmaceuticals. TrAC Trends in Analytical Chemistry , 101 pp. 120-128. 10.1016/j.trac.2017.10.026. Green open access
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Ovari, Gyorgy; Johnson, Thomas F; Foroutan, Farzad; Malmquist, Gunnar; Townsend, Matthew; Bracewell, Daniel G; (2024) Fabrication of electrospun ion exchanger adsorbents with morphologies designed for the separation of proteins and plasmid DNA. Journal of Chromatography A , 1734 , Article 465268. 10.1016/j.chroma.2024.465268. Green open access
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Pallipurath Radhakrishnan, AN; Marques, MPC; Davies, MJ; O'Sullivan, B; Bracewell, DG; Szita, N; (2018) Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents. Lab on a Chip 10.1039/C7LC00793K. (In press). Green open access
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Pamenter, George; Davies, Lee; Knevelman, Carol; Miskin, James; Mitrophanous, Kyriacos; Dikicioglu, Duygu; Bracewell, Daniel G; (2023) Time-dependent sorption behavior of lentiviral vectors during anion-exchange chromatography. Biotechnology and Bioengineering 10.1002/bit.28483. (In press). Green open access
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Papachristodoulou, M; Doutch, J; Leung, HSB; Church, A; Charleston, T; Clifton, LA; Butler, PD; ... Bracewell, DG; + view all (2020) In situ neutron scattering of antibody adsorption during protein A chromatography. Journal of Chromatography A , 1617 , Article 460842. 10.1016/j.chroma.2019.460842. Green open access
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Parau, M; Johnson, TF; Pullen, J; Bracewell, DG; (2022) Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy. Biotechnology Progress , 38 (2) , Article e3233. 10.1002/btpr.3233. Green open access
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Parau, Maria; Pullen, James; Bracewell, Daniel G; (2023) Depth filter material process interaction in the harvest of mammalian cells. Biotechnol Prog , Article e3329. 10.1002/btpr.3329. (In press). Green open access
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Partridge, TA; Ahmed, M; Choudhary, SB; van der Walle, CF; Patel, SM; Bishop, SM; Mantle, MD; (2019) Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution. Pharmaceutical Research , 36 (5) p. 71. 10.1007/s11095-019-2591-x. Green open access
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Patel, N; Bracewell, DG; Sorensen, E; (2018) Dynamic modelling of aqueous two-phase systems to quantify the impact of bioprocess design, operation and variability. Food and Bioproducts Processing , 107 pp. 10-24. 10.1016/j.fbp.2017.10.005. Green open access
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Pathak, M; Lintern, K; Chopda, V; Bracewell, DG; Rathore, AS; (2017) Fluorescence based real time monitoring of fouling in process chromatography. SCIENTIFIC REPORTS , 7 (ARTN 456) 10.1038/srep45640. Green open access
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Pathak, M; Lintern, K; Johnson, TF; Nair, AM; Mukherji, S; Bracewell, DG; Rathore, AS; (2019) Analytical tools for monitoring changes in physical and chemical properties of chromatography resin upon reuse. Electrophoresis , 40 (23-24) pp. 3074-3083. 10.1002/elps.201900089. Green open access
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Pathak, M; Rathore, AS; Lintern, K; Bracewell, DG; (2018) Protein A chromatography resin lifetime—impact of feed composition. Biotechnology Progress , 34 (2) pp. 412-419. 10.1002/btpr.2608. Green open access
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Peswani, AR; Narkpuk, J; Krueger, A; Bracewell, DG; Lekcharoensuk, P; Haslam, SM; Dell, A; ... Robinson, C; + view all (2022) Novel constructs and 1-step chromatography protocols for the production of Porcine Circovirus 2d (PCV2d) and Circovirus 3 (PCV3) subunit vaccine candidates. Food and Bioproducts Processing , 131 pp. 125-135. 10.1016/j.fbp.2021.10.001. Green open access
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Qiong, L; Gu, Q; He, W; (2019) Resilience of Chinese Teachers: Why Perceived Work Conditions and Relational Trust Matter. Measurement: Interdisciplinary Research and Perspectives , 17 (3) pp. 143-159. 10.1080/15366367.2019.1588593. Green open access
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Ramin, Elham; Cardillo, Antonio Gaetano; Liebers, Reinhard; Schmölder, Johannes; Von Lieres, Eric; Van Molle, Wim; Niebel, Bastian; ... Gernaey, Krist V; + view all (2024) Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities. Current Opinion in Chemical Engineering , 43 , Article 100998. 10.1016/j.coche.2023.100998. Green open access
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Ruscic, J; Perry, C; Mukhopadhyay, T; Takeuchi, Y; Bracewell, DG; (2019) Lentiviral Vector Purification Using Nanofiber Ion Exchange Chromatography. Molecular Therapy: Methods & Clinical Development , 15 pp. 52-62. 10.1016/j.omtm.2019.08.007. Green open access
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Sawant, N; Kaur, K; Holland, DA; Hickey, JM; Agarwal, S; Brady, JR; Dalvie, NC; ... Volkin, DB; + view all (2020) Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens. Journal of Pharmaceutical Sciences 10.1016/j.xphs.2020.11.039. (In press). Green open access
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Sexton, NJ; Cooper, RP; (2014) An architecturally constrained model of random number generation and its application to modeling the effect of generation rate. Frontiers in Psychology , 5 , Article 670. 10.3389/fpsyg.2014.00670. Green open access
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Sharma, Paras; Robbel, Lars; Schmitt, Michael; Dikicioglu, Duygu; Bracewell, Daniel G; (2024) Integrated micro-scale protein a chromatography and Low pH viral inactivation unit operations on an automated platform. Biotechnology Progress , Article e3476. 10.1002/btpr.3476. Green open access
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Sharma, A; Bracewell, DG; (2019) Characterisation of porous anodic alumina membranes for ultrafiltration of protein nanoparticles as a size mimic of virus particles. Journal of Membrane Science , 580 pp. 77-91. 10.1016/j.memsci.2019.02.071. Green open access
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Shi, Y; Thompson, J; Walker, A; PATON, NI; Cheung, YB; (2019) Mapping the Medical Outcomes Study HIV Health Survey (MOS-HIV) to the EuroQoL 5 Dimension (EQ-5D-3L) utility index. Health and Quality of Life Outcomes , 17 , Article 83. 10.1186/s12955-019-1135-8. Green open access
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Spice, AJ; Aw, R; Bracewell, DG; Polizzi, KM; (2020) Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort. Synthetic and Systems Biotechnology , 5 (3) pp. 137-144. 10.1016/j.synbio.2020.06.003. Green open access
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Spice, AJ; Aw, R; Bracewell, DG; Polizzi, KM; (2020) Synthesis and Assembly of Hepatitis B Virus-Like Particles in a Pichia pastoris Cell-Free System. Frontiers in Bioengineering and Biotechnology , 8 , Article 72. 10.3389/fbioe.2020.00072. Green open access
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Tait, AS; Tarrant, RD; Velez-Suberbie, ML; Spencer, DI; Bracewell, DG; (2013) Differential response in downstream processing of CHO cells grown under mild hypothermic conditions. Biotechnology Progress , 29 (3) pp. 688-696. 10.1002/btpr.1726. Green open access
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Tavakoli-Keshe, R; Phillips, JJ; Turner, R; Bracewell, DG; (2014) Understanding the Relationship Between Biotherapeutic Protein Stability and Solid-Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4. J Pharm Sci , 103 (2) pp. 437-444. 10.1002/jps.23822. Green open access
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Turnbull, J; Wright, B; Green, NK; Tarrant, R; Roberts, I; Hardick, O; Bracewell, DG; (2019) Adenovirus 5 recovery using nanofiber ion exchange adsorbents. Biotechnology and Bioengineering , 116 (7) pp. 1698-1709. 10.1002/bit.26972. Green open access
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Velez-Suberbie, ML; Morris, SA; Kaur, K; Hickey, JM; Joshi, SB; Volkin, DB; Bracewell, DG; (2020) Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation. Biotechnology Progress , 36 (3) , Article e2966. 10.1002/btpr.2966. Green open access
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Weil, BD; Jenkins, MJ; Uddin, S; Bracewell, DG; Wellings, D; Farid, SS; Veraitch, F; (2017) An integrated experimental and economic evaluation of cell therapy affinity purification technologies. Regenerative Medicine , 12 (4) pp. 397-417. 10.2217/rme-2016-0156. Green open access
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Wilson, LJ; Lewis, W; Kucia-Tran, R; Bracewell, DG; (2021) Identification and classification of host cell proteins during biopharmaceutical process development. Biotechnology Progress 10.1002/btpr.3224. (In press). Green open access
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Wilson, LJ; Lewis, W; Kucia-Tran, R; Bracewell, DG; (2019) Identification of Upstream Culture Conditions and Harvest Time Parameters That Affect Host Cell Protein Clearance. Biotechnology Progress , 35 (3) , Article e2805. 10.1002/btpr.2805. Green open access
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Thesis

Bracewell, DG; (2000) The use of optical biosensor for the real-time monitoring of product and product variants in biological process streams and application for control. University of London PhD thesis. UNSPECIFIED thesis , UNSPECIFIED.

This list was generated on Sun Sep 14 05:08:30 2025 BST.