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Manufacturing Exosomes: A Promising Therapeutic Platform

Colao, IL; Corteling, R; Bracewell, D; Wall, I; (2018) Manufacturing Exosomes: A Promising Therapeutic Platform. Trends in Molecular Medicine , 24 (3) pp. 242-256. 10.1016/j.molmed.2018.01.006. Green open access

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Abstract

Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progress towards the clinic for treatment of a vast array of diseases, it is important to define the engineering basis for their manufacture early in the development cycle to ensure they can be produced cost-effectively at the appropriate scale. We hypothesize that transitioning to defined manufacturing platforms will increase consistency of the exosome product and improve their clinical advancement as a new therapeutic tool. We present manufacturing technologies and strategies that are being implemented and consider their application for the transition from bench-scale to clinical production of exosomes.

Type: Article
Title: Manufacturing Exosomes: A Promising Therapeutic Platform
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.molmed.2018.01.006
Publisher version: http://doi.org/10.1016/j.molmed.2018.01.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: commercial manufacturing, exosomes, process development, regenerative medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10069527
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