Partridge, TA;
Ahmed, M;
Choudhary, SB;
van der Walle, CF;
Patel, SM;
Bishop, SM;
Mantle, MD;
(2019)
Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution.
Pharmaceutical Research
, 36
(5)
p. 71.
10.1007/s11095-019-2591-x.
Preview |
Text
Partridge2019_Article_ApplicationOfMagneticResonance.pdf - Published Version Download (3MB) | Preview |
Abstract
Dynamic in-situ proton (1H) magnetic resonance imaging (MRI) and 1H T2-relaxometry experiments are described in an attempt to: (i) understand the physical processes, that occur during the reconstitution of lyophilized bovine serum albumin (BSA) and monoclonal antibody (mAb) proteins; and (ii) objectify the reconstitution time.
| Type: | Article |
|---|---|
| Title: | Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11095-019-2591-x |
| Publisher version: | https://doi.org/10.1007/s11095-019-2591-x |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Dissolution, lyophilization, magnetic resonance imaging, protein concentration, protein formulation, reconstitution, T2 relaxation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10074308 |
Archive Staff Only
 |
View Item |
