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Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution

Partridge, TA; Ahmed, M; Choudhary, SB; van der Walle, CF; Patel, SM; Bishop, SM; Mantle, MD; (2019) Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution. Pharmaceutical Research , 36 (5) p. 71. 10.1007/s11095-019-2591-x. Green open access

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Abstract

Dynamic in-situ proton (1H) magnetic resonance imaging (MRI) and 1H T2-relaxometry experiments are described in an attempt to: (i) understand the physical processes, that occur during the reconstitution of lyophilized bovine serum albumin (BSA) and monoclonal antibody (mAb) proteins; and (ii) objectify the reconstitution time.

Type: Article
Title: Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11095-019-2591-x
Publisher version: https://doi.org/10.1007/s11095-019-2591-x
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Dissolution, lyophilization, magnetic resonance imaging, protein concentration, protein formulation, reconstitution, T2 relaxation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10074308
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