UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products

Bracewell, DG; Smith, V; Delahaye, M; Smales, CM; (2021) Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products. Current Opinion in Biotechnology , 71 pp. 98-104. 10.1016/j.copbio.2021.06.026. Green open access

[thumbnail of Bracewell_Analytics of HCPs Final_revised.pdf]
Preview
Text
Bracewell_Analytics of HCPs Final_revised.pdf - Accepted Version

Download (246kB) | Preview

Abstract

Analytics for host cell protein (HCP) analysis of therapeutic monoclonal antibody preparations have developed enormously. We consider how learnings from this can inform HCP analysis of gene therapy viral vector products. The application of mass spectrometry (MS) approaches for analysis of HCPs in viral vector preparations is being established, although such information remains limited and is yet to be widely applied into process or host cell line development to reduce HCP amounts or risk. As these MS approaches, and the data from them, are applied and become available, the process understanding created will speed process development activity. We describe technologies that have been, or can be, applied to viral vector HCP analysis to aid process development, reduce HCP amounts, identify critical HCPs and thus inform risk assessment and management based on a knowledge of specific HCPs, ultimately delivering safe and efficacious gene therapy products to the clinic.

Type: Article
Title: Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.copbio.2021.06.026
Publisher version: https://doi.org/10.1016/j.copbio.2021.06.026
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10134593
Downloads since deposit
230Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item