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Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development.

Espuny Garcia Del Real, G; Davies, J; Bracewell, DG; (2014) Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development. Biotechnol Bioeng , 111 (12) 2486 - 2498. 10.1002/bit.25313. Green open access

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Abstract

The authors present a novel ultra scale-down (USD) methodology for the characterization of flocculation processes. This USD method, consisting of a multiwell, magnetically agitated system that can be fitted on the deck of a liquid handling robot, mimicked the flocculation performance of a nongeometrically similar pilot-scale vessel representing greater than three orders of magnitude scale-up. Mixing scales (i.e. macromixing, mesomixing or micromixing) modulated the flocs' size and determined the success of some of the scale-up correlations reviewed in the literature.

Type: Article
Title: Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/bit.25313
Publisher version: http://dx.doi.org/10.1002/bit.25313
Language: English
Additional information: © 2014 The Authors. Biotechnology and Bioengineering published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: flocculation, high-throughput, micromixing, primary separation, scale-up, ultra scale-down
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1433438
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