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Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Nweke, MC; Rathore, AS; Bracewell, DG; (2018) Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture. [Editorial comment]. Trends in Biotechnology , 36 (10) pp. 992-995. 10.1016/j.tibtech.2018.01.001. Green open access

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Abstract

Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.

Type: Article
Title: Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibtech.2018.01.001
Publisher version: https://doi.org/10.1016/j.tibtech.2018.01.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: chromatography resin aging, chromatography resin lifetime, chromatography resin aging mechanisms, fouling characterisation techniques
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10071098
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