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Number of items: 80.
A
Affaticati, PE;
Dai, SB;
Payongsri, P;
Hailes, HC;
Tittmann, K;
Dalby, PA;
(2016)
Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.
Scientific Reports
, 6
, Article 35716. 10.1038/srep35716.
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Andersson, SEM;
Eneljung, T;
Tengvall, S;
Jirholt, P;
Stern, A;
Henningsson, L;
Liang, B;
... Gjertsson, I; + view all
(2016)
Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis.
Arthritis Research & Therapy
, 18
, Article 140. 10.1186/s13075-016-1037-7.
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Antemie, AM;
(2016)
Linking high throughput cell culture, multivariate analysis and economics for more effective process integration.
Doctoral thesis , UCL (University College London).
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Aoudjane, S;
(2016)
Bio-analytics - from current clinical practice to all-optical microfluidic technology.
Doctoral thesis , UCL (University College London).
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B
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Baert, J;
Delepierre, A;
Telek, S;
Fickers, P;
Toye, D;
Delamotte, A;
Lara, AR;
... Delvigne, F; + view all
(2016)
Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous metabolic biosensor.
Engineering in Life Sciences
, 16
(7)
pp. 643-651.
10.1002/elsc.201500149.
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Barata, TS;
Zhang, C;
Dalby, PA;
Brocchini, S;
Zloh, M;
(2016)
Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches.
International Journal of Molecular Sciences
, 17(6)
(853)
10.3390/ijms17060853.
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Borg, Y;
Grigonyte, AM;
Boeing, P;
Wolfenden, B;
Smith, P;
Beaufoy, W;
Rose, S;
... Nesbeth, DN; + view all
(2016)
Open source approaches to establishing Roseobacter Glade bacteria as synthetic biology chassis for biogeoengineering.
PeerJ
, 4
, Article e2031. 10.7717/peerj.2031.
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Branke, J;
Farid, SS;
Shah, N;
(2016)
Industry 4.0: a vision for personalized medicine supply chains?
Cell and Gene Therapy Insights
, 2
(2)
pp. 263-270.
10.18609/cgti.2016.027.
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C
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Call, TP;
Akhtar, MK;
Baganz, F;
Grant, C;
(2016)
Modulating the import of medium-chain alkanes in E. coli through tuned expression of FadL.
Journal of Biological Engineering
, 10
, Article 5. 10.1186/s13036-016-0026-3.
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Chakroun, N;
Hilton, D;
Ahmad, SS;
Platt, GW;
Dalby, PA;
(2016)
Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment.
Molecular Pharmaceutics
, 13
(2)
pp. 307-319.
10.1021/acs.molpharmaceut.5b00387.
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D
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Dalby, P;
(2016)
Conformational protein structure shifts in aggregation prone conditions for MAb and Fab.
Presented at: UNSPECIFIED.
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Dobrijevic, D;
Abraham, A-L;
Jamet, A;
Maguin, E;
van de Guchte, M;
(2016)
Functional Comparison of Bacteria from the Human Gut and Closely Related Non-Gut Bacteria Reveals the Importance of Conjugation and a Paucity of Motility and Chemotaxis Functions in the Gut Environment.
PLoS ONE
, 11
(7)
, Article e0159030. 10.1371/journal.pone.0159030.
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E
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Espuny Garcia del Real, G;
(2016)
Scale-Down Characterisation of Post-Centrifuge Flocculation Processes and the Study of its Impact upon Downstream Processing during Mammalian Cell Antibody Production.
Doctoral thesis , UCL (University College London).
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F
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Farid, SS;
(2016)
Allogeneic cell therapy process economics for successful development, manufacture and commercialisation.
Presented at: World Stem Cells & Regenerative Medicine Congress, London, UK.
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G
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Goldrick, S;
Mercer, E;
Montague, G;
Lovett, D;
Lennox, B;
(2016)
Control of an Industrial Scale Bioreactor using a PAT Analyser.
In:
IFAC Proceedings Volumes.
(pp. pp. 6222-6227).
ELSEVIER
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H
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Hamley-Bennett, C;
Lye, GJ;
Leak, DJ;
(2016)
Selective fractionation of sugar beet pulp for release of fermentation and chemical feedstocks: optimisation of thermo-chemical pre-treatment.
Bioresource Technology
, 209
pp. 259-264.
10.1016/j.biortech.2016.02.131.
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Hassan, S;
Huang, H;
Warren, K;
Mahdavi, B;
Smith, D;
Jong, S;
Farid, SS;
(2016)
Process change evaluation framework for allogeneic cell therapies: impact on drug development and commercialization.
Regenerative Medicine
, 11
(3)
pp. 287-305.
10.2217/rme-2015-0034.
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Hassan, S;
Keshavarz-Moore, E;
Ward, J;
(2016)
A cell engineering strategy to enhance supercoiled plasmid DNA production for gene therapy.
Biotechnology and Bioengineering
, 113
(9)
pp. 2064-2071.
10.1002/bit.25971.
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Heathman, TRJ;
Rafiq, QA;
Chan, AKC;
Coopman, K;
Nienow, AW;
Kara, B;
Hewitt, CJ;
(2016)
Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development.
Biochemical Engineering Journal
, 108
pp. 14-23.
10.1016/j.bej.2015.06.018.
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Heathman, TRJ;
Stolzing, A;
Fabian, C;
Rafiq, QA;
Coopman, K;
Nienow, AW;
Kara, B;
(2016)
Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate.
Cytotherapy
, 18
(4)
pp. 523-535.
10.1016/j.jcyt.2016.01.007.
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Hilton, DW;
(2016)
Elucidating the aggregation mechanisms of antibody fragments through biophysical analysis.
Doctoral thesis , UCL (University College London).
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Hussain, MS;
Ma, GJ;
Zhou, Y;
(2016)
Predicting Flux And Pressure Relationships of Large Scale Filtration with USD Model Inputs: Method and application.
Presented at: 13th Annual bioProcessUK Conference – Processing priorities for the future, Newcastle, United Kingdom.
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J
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Jeffries, JWE;
Dawson, N;
Orengo, C;
Moody, TS;
Quinn, DJ;
Hailes, HC;
Ward, JM;
(2016)
Metagenome Mining: A Sequence Directed Strategy for the Retrieval of Enzymes for Biocatalysis.
ChemistrySelect
, 1
(10)
pp. 2217-2220.
10.1002/slct.201600515.
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Jenkins, M;
Bilsland, J;
Allsopp, TE;
Ho, SV;
Farid, SS;
(2016)
Patient-specific hiPSC bioprocessing for drug screening: Bioprocess economics and optimisation.
Biochemical Engineering Journal
, 108
pp. 84-97.
10.1016/j.bej.2015.09.024.
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Joseph, A;
Kenty, B;
Mollet, M;
Hwang, K;
Rose, S;
Goldrick, S;
Bender, J;
... Titchener-Hooker, N; + view all
(2016)
A scale-down mimic for mapping the process performance of centrifugation, depth and sterile filtration.
Biotechnology and Bioengineering
, 113
(9)
pp. 1934-1941.
10.1002/bit.25967.
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K
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Kinna, A;
Tolner, B;
Rota, EM;
Titchener-Hooker, N;
Nesbeth, D;
Chester, K;
(2016)
IMAC capture of recombinant protein from unclarified mammalian cell feed streams.
Biotechnology and Bioengineering
, 113
(1)
pp. 130-140.
10.1002/bit.25705.
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Kirk, TV;
Marques, MPC;
Radhakrishnan, ANP;
Szita, N;
(2016)
Quantification of the oxygen uptake rate in a dissolved oxygen controlled oscillating jet-driven microbioreactor.
Journal of Chemical Technology and Biotechnology
, 91
(3)
pp. 823-831.
10.1002/jctb.4833.
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Kloetzer, L;
Petrila-Cocuz, I-B;
Galaction, A-I;
Szita, N;
Blaga, A-C;
Cascaval, D;
(2016)
Eco-friendly Production of Chemicals 1. Improvement of Enzymatic Production of Acetophenone by Direct Extraction.
Environmental Engineering and Management Journal
, 15
(8)
pp. 1849-1854.
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Kostas, E;
Stuart, W;
Daniel, W;
David, C;
(2016)
Optimization of a total acid hydrolysis based protocol for the quantification of carbohydrate in macroalgae.
Journal of Algal Biomass Utilization
, 7
(1)
pp. 21-36.
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L
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Lee, D;
Das, S;
Dawson, NL;
Dobrijevic, D;
Ward, J;
Orengo, C;
(2016)
Novel computational protocols for functionally classifying and characterising serine beta-lactamases.
PLoS Computational Biology
, 12
(6)
, Article e1004926. 10.1371/journal.pcbi.1004926.
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Lee, W;
(2016)
Directed evolution of bovine enterokinase for high functional expression in E.coli.
Doctoral thesis , UCL (University College London).
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Lichman, BR;
(2016)
Norcoclaurine synthase: the mechanism and biocatalytic potential of a Pictet-Spenglerase.
Doctoral thesis , UCL (University College London).
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Lintern, K;
Pathak, M;
Smales, CM;
Howland, K;
Rathore, A;
Bracewell, DG;
(2016)
Residual on column host cell protein analysis during lifetime studies of protein A chromatography.
Journal of Chromatography A
, 1461
pp. 70-77.
10.1016/j.chroma.2016.07.055.
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Liu, S;
Farid, SS;
Papageorgiou, LG;
(2016)
Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach.
Industrial & Engineering Chemistry Research
, 55
(16)
pp. 4599-4612.
10.1021/acs.iecr.5b04403.
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Liu, S;
Ruban, L;
Wang, Y;
Zhou, Y;
Nesbeth, DN;
(2016)
Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrickTM design, serum-free virus production and microcarrier-based cultivation of CV-1 cells.
BioRxiv
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Lizzul, AM;
(2016)
Integrated production of algal biomass.
Doctoral thesis , UCL (University College London).
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Lou, S-C;
Wetzel, S;
Zhang, H;
Crone, EW;
Lee, Y-T;
Jackson, SE;
Hsu, S-TD;
(2016)
The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates.
Journal of Molecular Biology
, 428
(11)
pp. 2507-2520.
10.1016/j.jmb.2016.04.002.
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M
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Ma, G;
Zhou, Y;
(2016)
Ultra Scale-down Tools to Accelerate Process Development.
Presented at: BioTalk 2016: Biological Manufacturing Excellence, Berlin, Germany.
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Mahajan, E;
Lye, G;
(2016)
Bridging polymer science and biotechnology applications with single-use technologies.
BioProcess International
, 14
(6)
pp. 22-27.
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Markosova, K;
Dolejs, I;
Stloukal, R;
Rios-Solis, L;
Rosenberg, M;
Micheletti, M;
Lye, GJ;
... Rebros, M; + view all
(2016)
Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels.
Journal of Molecular Catalysis B: Enzymatic
, 129
pp. 69-74.
10.1016/j.molcatb.2016.04.009.
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Mayer, MJ;
Juodeikis, R;
Brown, IR;
Frank, S;
Palmer, DJ;
Deery, E;
Beal, DM;
... Warren, MJ; + view all
(2016)
Effect of bio-engineering on size, shape, composition and rigidity of bacterial microcompartments.
Scientific Reports
, 6
, Article 36899. 10.1038/srep36899.
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Mazzer, A;
(2016)
Understanding the Influence of Adsorption-Mediated Processes on Antibody Aggregation in Bioprocessing.
Doctoral thesis , UCL (University College London).
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McDonnell, TCR;
(2016)
Does PEGylated DI have the potential to be an effective therapeutic for Antiphospholipid Syndrome?
Doctoral thesis , UCL (University College London).
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Mohtasham, P;
Keshavarz-Moore, E;
Kale, I;
Keshavarz, T;
(2016)
Application of Magnetic Field for Improvement of Microbial Productivity.
5TH INTERNATIONAL SYMPOSIUM ON INDUSTRIAL BIOTECHNOLOGY (IBIC 2016)
, 49
pp. 43-48.
10.3303/CET1649008.
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Morris, P;
Rios-Solis, L;
García-Arrazola, R;
Lye, GJ;
Dalby, PA;
(2016)
Impact of cofactor-binding loop mutations on thermotolerance and activity of E. coli transketolase.
Enzyme and Microbial Technology
, 89
pp. 85-91.
10.1016/j.enzmictec.2016.04.003.
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N
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Nesbeth, DN;
Zaikin, A;
Saka, Y;
Romano, MC;
Giuraniuc, CV;
Kanakov, O;
Laptyeva, T;
(2016)
Synthetic biology routes to bio-artificial intelligence.
Essays in Biochemistry
, 60
(4)
pp. 381-391.
10.1042/EBC20160014.
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Newton, JM;
Schofield, D;
Vlahopoulou, J;
Zhou, Y;
(2016)
Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss.
Biotechnology Progress
, 32
(4)
pp. 1069-1076.
10.1002/btpr.2292.
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Newton, JM;
Vlahopoulou, J;
Zhou, Y;
(2016)
Rheological Monitoring of Cell Lysis in E. coli Fermentation using acoustic sensors.
Presented at: BioProNet 3rd Annual Scientific Symposium, Nottingham, United Kingdom.
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Nienow, AW;
Hewitt, CJ;
Heathman, TRJ;
Glyn, VAM;
Fonte, GN;
Hanga, MP;
Coopman, K;
(2016)
Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms.
Biochemical Engineering Journal
, 108
pp. 24-29.
10.1016/j.bej.2015.08.003.
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Nilsson, SM;
(2016)
Process development of lentiviral vector expression, purification and formulation for gene therapy applications.
Doctoral thesis , UCL (University College London).
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Nweke, MC;
Turmaine, M;
McCartney, RG;
Bracewell, DG;
(2016)
Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy.
Biotechnology Journal
, 12
(3)
, Article 1600583. 10.1002/biot.201600583.
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P
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Pallipurath Radhakrishnan, AN;
(2016)
Elucidation of Flocculation Growth Kinetics Using a Microfluidic Approach.
Doctoral thesis , UCL (University College London).
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Pericleous, C;
Ferreira, I;
Borghi, O;
Pregnolato, F;
McDonnell, T;
Garza-Garcia, A;
Driscoll, P;
... Rahman, A; + view all
(2016)
Measuring IgA anti-β2-glycoprotein I and IgG/IgA anti-domain I antibodies adds value to current serological assays for the antiphospholipid syndrome.
PLoS One
, 11
(6)
, Article e0156407. 10.1371/journal.pone.0156407.
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Pieralisi, I;
Rodriguez, G;
Micheletti, M;
Paglianti, A;
Ducci, A;
(2016)
Microcarriers' suspension and flow dynamics in orbitally shaken bioreactors.
Chemical Engineering Research and Design
, 108
pp. 198-209.
10.1016/j.cherd.2015.11.020.
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Planamente, S;
Salih, O;
Manoli, E;
Albesa-Jove, D;
Freemont, PS;
Filloux, A;
(2016)
TssA forms a gp6-like ring attached to the type VI secretion sheath.
EMBO Journal
, 35
(15)
pp. 1613-1627.
10.15252/embj.201694024.
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Popova, D;
(2016)
Robust strategy development for primary recovery of high cell density mammalian cell cultures using ultra scale-down models.
Doctoral thesis , UCL (University College London).
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Popova, D;
Stonier, A;
Pain, D;
Titchener-Hooker, NJ;
Farid, SS;
(2016)
Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures.
Biotechnology Journal
, 11
(7)
pp. 899-909.
10.1002/biot.201500336.
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R
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Rafiq, QA;
Thomas, RJ;
(2016)
The evolving role of automation in process development & manufacture of cell & gene-based therapies.
Cell and Gene Therapy Insights
, 2
(4)
pp. 473-479.
10.18609/cgti.2016.058.
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Rafiq, QA;
Twomey, K;
Kulik, M;
Leschke, C;
O'Dea, J;
Callens, S;
Gentili, C;
... Murphy, M; + view all
(2016)
Developing an automated robotic factory for novel stem cell therapy production.
Regenerative Medicine
, 11
(4)
pp. 351-354.
10.2217/rme-2016-0040.
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Raimes, W;
Rubi, M;
Super, ASM;
Marques, M;
Veraitch, F;
Szita, N;
(2016)
Transfection in perfused microfluidic cell culture devices: a case study.
Process Biochemistry
10.1016/j.procbio.2016.09.006.
(In press).
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Rayat, ACME;
Chatel, A;
Hoare, M;
Lye, GJ;
(2016)
Ultra scale-down approaches to enhance the creation of bioprocesses at scale: impacts of process shear stress and early recovery stages.
Current Opinion in Chemical Engineering
, 14
pp. 150-157.
10.1016/j.coche.2016.09.012.
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Robinson, MJ;
(2016)
Investigating the relationship between forced degradation and long-term shelf life for biotherapeutics.
Doctoral thesis , UCL (University College London).
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Routledge, SJ;
Mikaliunaite, L;
Patel, A;
Clare, M;
Cartwright, SP;
Bawa, Z;
Wilks, MDB;
... Bill, RM; + view all
(2016)
The synthesis of recombinant membrane proteins in yeast for structural studies.
Methods
, 95
pp. 26-37.
10.1016/j.ymeth.2015.09.027.
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S
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Schofield, DM;
(2016)
Synthetic biology approaches to bioprocess intensification in bacterial and mammalian production platforms.
Doctoral thesis , UCL (University College London).
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Schofield, DM;
Templar, A;
Newton, J;
Nesbeth, DN;
(2016)
Promoter engineering to optimise recombinant periplasmic Fab' fragment production in Escherichia coli.
Biotechnology Progress
, 32
(4)
pp. 840-847.
10.1002/btpr.2273.
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Subrizi, F;
Cárdenas-Fernández, M;
Lye, GJ;
Ward, JM;
Dalby, PA;
Sheppard, TD;
Hailes, HC;
(2016)
Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose.
Green Chemistry
, 18
(10)
pp. 3158-3165.
10.1039/C5GC02660A.
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Super, A;
Jaccard, N;
Cardoso Marques, MP;
Macown, RJ;
Griffin, LD;
Veraitch, FS;
Szita, N;
(2016)
Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device.
Biotechnology Journal
, 11
(9)
pp. 1179-1189.
10.1002/biot.201500479.
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T
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Templar, A;
Marsh, D;
Nesbeth, DN;
(2016)
A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction.
SpringerPlus
, 5
, Article 1510. 10.1186/s40064-016-3074-8.
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Templar, A;
Woodhouse, S;
Keshavarz-Moore, E;
Nesbeth, DN;
(2016)
Influence of Pichia pastoris cellular material on polymerase chain reaction performance as a synthetic biology standard for genome monitoring.
Journal of Microbiological Methods
, 127
pp. 111-122.
10.1016/j.mimet.2016.05.013.
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Tengvall, S;
Eneljung, T;
Jirholt, P;
Turesson, O;
Wing, K;
Holmdahl, R;
Kihlberg, J;
... Gjertsson, I; + view all
(2016)
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
PLoS ONE
, 11
(5)
, Article e0154630. 10.1371/journal.pone.0154630.
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Thomas, S;
Straathof, K;
Himoudi, N;
Anderson, J;
Pule, M;
(2016)
An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers.
PLoS One
, 11
(3)
, Article e0152196. 10.1371/journal.pone.0152196.
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Torres-Acosta, MA;
Aguilar-Yáñez, JM;
Rito-Palomares, M;
Titchener-Hooker, NJ;
(2016)
Economic analysis of Uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle).
Biotechnology Progress
, 32
(1)
pp. 126-133.
10.1002/btpr.2200.
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V
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Vahid Dastjerdi, F;
(2016)
Novel Recombinant Antibodies to EGFRvIII.
Doctoral thesis , UCL (University College London).
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Voulgaris, I;
Chatel, A;
Finka, G;
Uden, M;
Hoare, M;
(2016)
Evaluation of options for harvest of a recombinant E. coli fermentation producing a domain antibody using ultra scale-down techniques and pilot-scale verification.
Biotechnology Progress
, 32
(2)
pp. 382-392.
10.1002/btpr.2220.
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W
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Wall, IB;
Toledo, GS;
Jat, PS;
(2016)
Recent advances in conditional cell immortalization technology.
Cell & Gene Therapy Insights
, 2
(3)
pp. 391-396.
10.18609/cgti.2016.041.
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Widner, FJ;
Lawrence, AD;
Deery, E;
Heldt, D;
Frank, S;
Gruber, K;
Wurst, K;
... Kraeutler, B; + view all
(2016)
Total Synthesis, Structure, and Biological Activity of Adenosylrhodibalamin, the Non-Natural Rhodium Homologue of Coenzyme B-12.
In:
(Proceedings) 6th EuCheMS Chemistry Congress.
(pp. pp. 11281-11286).
WILEY-V C H VERLAG GMBH
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Woodhouse, SA;
(2016)
An upstream platform for the production of high grade heterologous proteins in the yeast Pichia pastoris.
Doctoral thesis , UCL (University College London).
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Wu, T;
(2016)
An intelligent automation platform for bioprocess development.
Doctoral thesis , UCL (University College London).
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X
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Xu, Y;
Hellier, P;
Purton, S;
Baganz, F;
Ladommatos, N;
(2016)
Algal biomass and diesel emulsions: An alternative approach for utilizing the energy content of microalgal biomass in diesel engines.
Applied Energy
, 172
pp. 80-95.
10.1016/j.apenergy.2016.03.019.
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Z
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Zhou, Y;
Torres-Acosta, MA;
Rito-Palomares, M;
Aguilar-Yáñez, JM;
Titchener-Hooker, NJ;
(2016)
Economic Evaluation of ATPS-based Bioprocesses.
Presented at: 2nd BioSolve User Group Forum: Harmonizing the community through innovation, London, United Kingdom.
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