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Recent advances in conditional cell immortalization technology

Wall, IB; Toledo, GS; Jat, PS; (2016) Recent advances in conditional cell immortalization technology. Cell & Gene Therapy Insights , 2 (3) pp. 391-396. 10.18609/cgti.2016.041. Green open access

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Abstract

Gene-modified cell therapies are transforming medicine. Over the last 18 months, notable clinical successes using antigen-targeting cellular immunotherapies have been achieved. However, another kind of gene modification has significant potential for the cell therapy industry. The development of fully controllable transgenes has enabled the creation of conditionally immortalized cells that can be expanded to clinical quantities in a stable and consistent fashion, yet can be returned to a normal, non-dividing state for therapeutic delivery to the patient. In this article, we discuss some of the key technologies that have been used to create conditionally immortalized cells for clinical development.

Type: Article
Title: Recent advances in conditional cell immortalization technology
Open access status: An open access version is available from UCL Discovery
DOI: 10.18609/cgti.2016.041
Publisher version: http://doi.org/10.18609/cgti.2016.041
Language: English
Additional information: This work is licensed under a Creative Commons Attribution – NonCommercial – NoDerivatives 4.0 International License.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1522367
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