UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose

Subrizi, F; Cárdenas-Fernández, M; Lye, GJ; Ward, JM; Dalby, PA; Sheppard, TD; Hailes, HC; (2016) Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose. Green Chemistry , 18 (10) pp. 3158-3165. 10.1039/C5GC02660A. Green open access

[thumbnail of c5gc02660a.pdf]
Preview
Text
c5gc02660a.pdf - Published Version

Download (811kB) | Preview

Abstract

Conversion of biomass using biocatalysis is likely to become a technology that contributes significantly to the future production of chemical building blocks, materials and transport fuels. Here the synthesis of a value-added chemical from L-arabinose, a major component of the carbohydrates in sugar beet pulp (SBP), in a concise and sustainable manner has been investigated. Biocatalytic conversions using transketolase variants have been developed for the efficient, scalable synthesis of a rare naturally occurring ketoheptose, L-gluco-heptulose, from L-arabinose. New active E. coli TK mutants that readily accept L-arabinose were identified using a versatile colorimetric screening assay and the reaction was performed on a preparative scale.

Type: Article
Title: Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C5GC02660A
Publisher version: http://dx.doi.org/10.1039/C5GC02660A
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1495981
Downloads since deposit
115Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item