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Control of an Industrial Scale Bioreactor using a PAT Analyser

Goldrick, S; Mercer, E; Montague, G; Lovett, D; Lennox, B; (2016) Control of an Industrial Scale Bioreactor using a PAT Analyser. In: IFAC Proceedings Volumes. (pp. pp. 6222-6227). ELSEVIER Green open access

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Abstract

This work investigates the application of a “Process Analytical Technology” (PAT) analyser to control the substrate concentration over traditional sequential batch control for an industrial scale fed-batch penicillin fermentation. A simulation that utilises the historical data from four batches, where a sequential batch control strategy was implemented, was used as the benchmark reference for this comparison. The simulation accurately predicts the main outputs variables of biomass and penicillin, given the inputs from the historical data set. The simulation includes a PAT analyser, used to build a calibration model with the available off-line substrate concentration from one of the batches. The prediction from this calibration model was used as the controlled variable within a proportional integral (PI) controller to manipulate the substrate feed rate for the three remaining batches. Performance of each control strategy was analysed by comparing the final penicillin yield of each batch. An increase of 35, 20 and 9% was observed for the three batches controlled using the PI controller compared with the sequential batch control strategy.

Type: Proceedings paper
Title: Control of an Industrial Scale Bioreactor using a PAT Analyser
Event: 19th World Congress of the International-Federation-of-Automatic-Control (IFAC)
Location: Cape Town, SOUTH AFRICA
Dates: 24 August 2014 - 29 August 2014
Open access status: An open access version is available from UCL Discovery
DOI: 10.3182/20140824-6-ZA-1003.02589
Publisher version: https://doi.org/10.3182/20140824-6-ZA-1003.02589
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Industrial biotechnology, Microbial technology, FED-BATCH CULTIVATION, PENICILLIUM-CHRYSOGENUM, MODEL
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10065403
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