Zhou, Y; Torres-Acosta, MA; Rito-Palomares, M; Aguilar-Yáñez, JM; Titchener-Hooker, NJ; (2016) Economic Evaluation of ATPS-based Bioprocesses. Presented at: 2nd BioSolve User Group Forum: Harmonizing the community through innovation, London, United Kingdom.

Slideshow Economic evaluation of ATPS-based bioprocess 2016.ppt - Published Version Download (3MB)

Abstract

Aqueous two-phase systems (ATPS) have been developed as an intensive unit operations that can be easily scaled-up and doesn’t require complex equipment for operation for protein purification. Although ATPS has been used successfully to recover/purify diverse bioproducts, there is a lack of information on how they affect production costs. The present study analyzed production costs and their behaviors for ATPS-based bioprocess through bioprocess modelling of the production of diverse protein products. This analysis included the contrast of ATPS versus chromatography to purify a pharmaceutical protein and a commercial attractiveness test for ATPS at pilot-scale to purify a costly protein for molecular biology applications. Results indicate that ATPS is less expensive than chromatography, but has a large impact in the amount of materials required. The addition of a recycling step proved to reduce almost 60% of wastes without an additional charge to the production cost. ATPS demonstrated a potential commercial success as its inclusion to a bioprocess generated large profits by decreasing production costs. ATPS should be considered for future developments as they are demonstrating to be cost-effective when applied to bioprocessing.

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