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Number of items: 84.
Article
Affaticati, PE;
Dai, SB;
Payongsri, P;
Hailes, HC;
Tittmann, K;
Dalby, PA;
(2016)
Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.
Scientific Reports
, 6
, Article 35716. 10.1038/srep35716.
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Aucamp, JP;
Cosme, AM;
Lye, GJ;
Dalby, PA;
(2005)
High-throughput measurement of protein stability in microtiter plates.
BIOTECHNOL BIOENG
, 89
(5)
599 - 607.
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Barata, TS;
Zhang, C;
Dalby, PA;
Brocchini, S;
Zloh, M;
(2016)
Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches.
International Journal of Molecular Sciences
, 17(6)
(853)
10.3390/ijms17060853.
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Bradford, HF;
Lalaurie, CJ;
Gor, J;
Gao, X;
Pericleous, C;
Perkins, SJ;
Britt, H;
... McDonnell, TCR; + view all
(2025)
Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies.
Journal of Thrombosis and Haemostasis
, 23
(6)
pp. 1864-1878.
10.1016/j.jtha.2025.02.015.
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Cárdenas-Fernández, M;
Bawn, M;
Hamley-Bennett, C;
Bharat, PKV;
Subrizi, F;
Suhaili, N;
Ward, DP;
... Lye, GJ; + view all
(2017)
An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates.
Faraday Discuss
, 202
pp. 415-431.
10.1039/c7fd00094d.
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Carrillo Sanchez, Braulio;
Fernández-García, Raquel;
Gerontas, Spyridon;
Hales, John E;
Aylott, Jonathan W;
Dalby, Paul A;
(2025)
Systematic formulation optimisation to enhance buffer exchange recovery and storage stability for adeno-associated virus (AAV2) vectors.
International Journal of Pharmaceutics
, 686
, Article 126312. 10.1016/j.ijpharm.2025.126312.
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Chakroun, N;
Hilton, D;
Ahmad, SS;
Platt, GW;
Dalby, PA;
(2016)
Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment.
Molecular Pharmaceutics
, 13
(2)
pp. 307-319.
10.1021/acs.molpharmaceut.5b00387.
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Chauhan, VM;
Zhang, H;
Dalby, PA;
Aylott, JW;
(2020)
Advancements in the co-formulation of biologic therapeutics.
Journal of Controlled Release
, 327
pp. 397-405.
10.1016/j.jconrel.2020.08.013.
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Codina, N;
Hilton, D;
Zhang, C;
Chakroun, N;
Ahmad, SS;
Perkins, SJ;
Dalby, PA;
(2019)
An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics and smFRET Identifies an Aggregation Mechanism.
Journal of Molecular Biology
10.1016/j.jmb.2019.02.009.
(In press).
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Colin, P-Y;
Dalby, PA;
(2020)
Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase.
Scientific Reports
, 10
, Article 21841. 10.1038/s41598-020-79026-2.
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Costelloe, S.J.;
Ward, J.M.;
Dalby, P.A.;
(2008)
Evolutionary analysis of the TPP-dependent enzyme family.
Journal of Molecular Evolution
, 66
(1)
pp. 36-49.
10.1007/s00239-007-9056-2.
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Deszcz, D;
Affaticati, P;
Ladkau, N;
Gegel, A;
Ward, JM;
Hailes, HC;
Dalby, PA;
(2015)
Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase.
The FEBS Journal
, 282
(13)
pp. 2512-2526.
10.1111/febs.13293.
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Du, CJ;
Rios-Solis, L;
Ward, JM;
Dalby, PA;
Lye, GJ;
(2014)
Evaluation of CV2025 ω-transaminase for the bioconversion of lignin breakdown products into value-added chemicals: synthesis of vanillylamine from vanillin.
Biocatalysis and Biotransformation
, 32
(5-6)
pp. 302-313.
10.3109/10242422.2014.976632.
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Elia Venanzi, Niccolo Alberto;
Basciu, Andrea;
Vargiu, Attilio Vittorio;
Kiparissides, Alexandros;
Dalby, Paul A;
Dikicioglu, Duygu;
(2024)
Machine Learning Integrating Protein Structure, Sequence, and
Dynamics to Predict the Enzyme Activity of Bovine Enterokinase
Variants.
Journal of Chemical Information and Modeling
10.1021/acs.jcim.3c00999.
(In press).
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Galman, JL;
Steadman, D;
Bacon, S;
Morris, P;
Smith, MEB;
Ward, JM;
Dalby, PA;
(2010)
alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes.
Chemical Communications
, 46
(40)
7608 - 7610.
10.1039/c0cc02911d.
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Grant, C;
Deszcz, D;
Wei, YC;
Martínez-Torres, RJ;
Morris, P;
Folliard, T;
Sreenivasan, R;
... Baganz, F; + view all
(2014)
Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes.
Sci Rep
, 4
, Article 5844. 10.1038/srep05844.
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Groves, K;
Ashcroft, AE;
Cryar, A;
Sula, A;
Wallace, BA;
Stocks, BB;
Burns, C;
... Quaglia, M; + view all
(2021)
Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison.
Analytical Chemistry
, 93
(26)
pp. 9041-9048.
10.1021/acs.analchem.0c04625.
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Guo, H;
Li, W;
Zhu, C;
Chen, Y;
Dalby, PA;
Fan, D;
(2023)
Enhancement of thermal stability of Bacillus subtilis 168 glycosyltransferase YjiC based on PoPMuSiC algorithm and its catalytic conversion of rare ginsenoside PPD.
Process Biochemistry
, 132
pp. 1-12.
10.1016/j.procbio.2023.07.005.
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Hales, JE;
Aoudjane, S;
Aeppli, G;
Dalby, PA;
(2021)
Proof-of-concept analytical instrument for label-free optical de-convolution of protein species in a mixture.
Journal of Chromatography A
, 1641
, Article 461968. 10.1016/j.chroma.2021.461968.
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Hales, JE;
Matmon, G;
Dalby, PA;
Ward, JM;
Aeppli, G;
(2019)
Virus lasers for biological detection.
Nature Communications
, 10
(1)
, Article 3594. 10.1038/s41467-019-11604-z.
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Hibbert, EG;
Dalby, PA;
(2005)
Directed evolution strategies for improved enzymatic performance.
Microbial Cell Factories
, 4
, Article 29. 10.1186/1475-2859-4-29.
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Jiang, Z;
Dalby, PA;
(2023)
Challenges in scaling up AAV-based gene therapy manufacturing.
Trends in Biotechnology
, 41
(10)
pp. 1268-1281.
10.1016/j.tibtech.2023.04.002.
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Kellerman, Mark-Adam W;
Almeida, Teresa;
Rudd, Timothy R;
Matejtschuk, Paul;
Dalby, Paul A;
(2022)
NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.2c00398.
(In press).
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Lalaurie, Christophe J;
Splevins, Andrew;
Barata, Teresa S;
Bunting, Karen A;
Higazi, Daniel R;
Zloh, Mire;
Spiteri, Valentina A;
... Dalby, Paul A; + view all
(2022)
Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E.
J Struct Biol
, 214
(3)
, Article 107876. 10.1016/j.jsb.2022.107876.
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Lalaurie, CJ;
Kulke, M;
Geist, N;
Delcea, M;
Dalby, PA;
McDonnell, TCR;
(2025)
The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II.
Journal of Structural Biology X
, 12
, Article 100135. 10.1016/j.yjsbx.2025.100135.
(In press).
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Lalaurie, CJ;
Zloh, M;
Higazi, DR;
Bunting, KA;
Dalby, PA;
(2025)
Inter-Domain interactions Slow BoNT/A’s onset of action.
Journal of Structural Biology
, 217
(1)
, Article 108171. 10.1016/j.jsb.2025.108171.
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Lee, Weiluo;
Pradhan, Subhas;
Zhang, Cheng;
Venanzi, Niccolo AE;
Li, Weina;
Goldrick, Stephen;
Dalby, Paul A;
(2022)
Directed evolution for soluble and active periplasmic expression of bovine enterokinase in Escherichia coli.
Scientific Reports
, 12
, Article 17721. 10.1038/s41598-022-22574-6.
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Li, Yiwen;
Dalby, Paul A;
(2022)
Engineering of enzymes using non-natural amino acids.
Bioscience Reports
, 42
, Article 8. 10.1042/BSR20220168.
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Lyu, Xiaochen;
Zhao, Qichao;
Hui, Julia;
Wang, Tiffany;
Lin, Mengyi;
Wang, Keying;
Zhang, Jialing;
... Liu, Bo; + view all
(2022)
The global landscape of approved antibody therapies.
Antibody Therapeutics
, 5
(4)
pp. 233-257.
10.1093/abt/tbac021.
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Morris, P;
García-Arrazola, R;
Rios-Solis, L;
Dalby, PA;
(2021)
Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents.
Scientific Reports
, 11
, Article 23584. 10.1038/s41598-021-03001-8.
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Morris, P;
Rios-Solis, L;
García-Arrazola, R;
Lye, GJ;
Dalby, PA;
(2016)
Impact of cofactor-binding loop mutations on thermotolerance and activity of E. coli transketolase.
Enzyme and Microbial Technology
, 89
pp. 85-91.
10.1016/j.enzmictec.2016.04.003.
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Mukhopadhyay, Arka;
Karu, Kersti;
Dalby, Paul A;
(2024)
Two-substrate enzyme engineering using small libraries that combine the substrate preferences from two different variant lineages.
Scientific Reports
, 14
, Article 1287. 10.1038/s41598-024-51831-z.
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Pandya, Akash;
Zhang, Cheng;
Barata, Teresa S;
Brocchini, Steve;
Howard, Mark J;
Zloh, Mire;
Dalby, Paul A;
(2024)
Molecular Dynamics Simulations Reveal How Competing Protein-Surface Interactions for Glycine, Citrate, and Water Modulate Stability in Antibody Fragment Formulations.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.4c00332.
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Pandya, A;
Howard, MJ;
Zloh, M;
Dalby, PA;
(2018)
An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations.
Pharmaceutics
, 10
(4)
, Article 165. 10.3390/pharmaceutics10040165.
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Patterson, R;
Nerren, J;
Kogut, M;
Court, P;
Villarreal-Ramos, B;
Seyfert, HM;
Dalby, P;
(2012)
Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.
Developmental & Comparative Immunology
, 37
(1)
107 - 114.
10.1016/j.dci.2011.10.009.
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Payongsri, P;
Steadman, D;
Hailes, HC;
Dalby, PA;
(2015)
Second generation engineering of transketolase for polar aromatic aldehyde substrates.
Enzyme and Microbial Technology
, 71
pp. 45-52.
10.1016/j.enzmictec.2015.01.008.
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Payongsri, P;
Steadman, D;
Strafford, J;
MacMurray, A;
Hailes, HC;
Dalby, PA;
(2012)
Rational substrate and enzyme engineering of transketolase for aromatics.
Organic & Biomolecular Chemistry
, 10
(45)
9021 - 9029.
10.1039/c2ob25751c.
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Polykarpou, EM;
Dalby, PA;
Papageorgiou, LG;
(2012)
An MILP formulation for the synthesis of protein purification processes.
Chemical Engineering Research and Design
, 90
(9)
1262 - 1270.
10.1016/j.cherd.2011.11.021.
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Rayner, LE;
Hui, GK;
Gor, J;
Heenan, RK;
Dalby, PA;
Perkins, SJ;
(2015)
The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands.
J Biol Chem
, 290
(13)
8420 - 8438.
10.1074/jbc.M114.631002.
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Rayner, LE;
Hui, GK;
Gor, J;
Heenan, RK;
Dalby, PA;
Perkins, SJ;
(2014)
The Fab conformations in the solution structure of human IgG4 restricts access to its Fc region: implications for functional activity.
J Biol Chem
, 289
(30)
pp. 20740-20756.
10.1074/jbc.M114.572404.
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Rayner, LE;
Kadkhodayi-Kholghi, N;
Heenan, RK;
Gor, J;
Dalby, PA;
Perkins, SJ;
(2013)
The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability.
Journal of Molecular Biology
, 425
(3)
506 - 523.
10.1016/j.jmb.2012.11.019.
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Rios-Solis, L;
Halim, M;
Cazares, A;
Morris, P;
Ward, JM;
Hailes, HC;
Dalby, PA;
... Lye, GJ; + view all
(2011)
A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a 'mix and match' E. coli expression system with microscale experimentation.
Biocatalysis and Biotransformation
, 29
(5)
pp. 192-203.
10.3109/10242422.2011.609589.
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Rios-Solis, L;
Morris, P;
Grant, C;
Odeleye, AOO;
Hailes, HC;
Ward, JM;
Dalby, PA;
... Lye, GJ; + view all
(2015)
Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination.
CHEMICAL ENGINEERING SCIENCE
, 122
360 - 372.
10.1016/j.ces.2014.09.046.
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Robinson, MJ;
Matejtschuk, P;
Bristow, AF;
Dalby, PA;
(2017)
Tm-values and unfolded fraction can predict aggregation rates for GCSF variant formulations, but not under predominantly native conditions.
Mol Pharm
10.1021/acs.molpharmaceut.7b00876.
(In press).
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Robinson, MJ;
Matejtschuk, P;
Longstaff, C;
Dalby, PA;
(2019)
Selective stabilisation and destabilisation of protein domains in tissue-type plasminogen activator using formulation excipients.
Molecular Pharmaceutics
, 16
(2)
pp. 744-755.
10.1021/acs.molpharmaceut.8b01024.
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Sagar, DM;
Aoudjane, S;
Gaudet, M;
Aeppli, G;
Dalby, PA;
(2013)
Optically Induced Thermal Gradients for Protein Characterization in Nanolitre-scale Samples in Microfluidic Devices.
Scientific Reports
, 3
, Article 2130. 10.1038/srep02130.
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Shen, Wenfeng;
Dalby, Paul A;
Guo, Zheng;
Li, Weina;
Zhu, Chenhui;
Fan, Daidi;
(2023)
Residue Effect-Guided Design: Engineering of S. Solfataricus β-Glycosidase to Enhance Its Thermostability and Bioproduction of Ginsenoside Compound K.
Journal of Agricultural and Food Chemistry
, 71
(44)
pp. 16669-16680.
10.1021/acs.jafc.3c04575.
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Spiteri, VA;
Doutch, J;
Rambo, RP;
Gor, J;
Dalby, PA;
Perkins, SJ;
(2021)
Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation.
Biophysical Journal
, 120
(9)
pp. 1814-1834.
10.1016/j.bpj.2021.02.038.
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Spiteri, Valentina A;
Doutch, James;
Rambo, Robert P;
Bhatt, Jayesh S;
Gor, Jayesh;
Dalby, Paul A;
Perkins, Stephen J;
(2024)
Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4.
PLoS One
, 19
(4)
, Article e0300964. 10.1371/journal..
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Strafford, J;
Payongsri, P;
Hibbert, EG;
Morris, P;
Batth, SS;
Steadman, D;
Smith, ME;
... Dalby, PA; + view all
(2012)
Directed evolution to re-adapt a co-evolved network within an enzyme.
Journal of Biotechnology
, 157
(1)
237 - 245.
10.1016/j.jbiotec.2011.11.017.
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Subrizi, F;
Cárdenas-Fernández, M;
Lye, GJ;
Ward, JM;
Dalby, PA;
Sheppard, TD;
Hailes, HC;
(2016)
Transketolase catalysed upgrading of l -arabinose: the one-step stereoselective synthesis of l -gluco-heptulose.
Green Chemistry
, 18
(10)
pp. 3158-3165.
10.1039/C5GC02660A.
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Tang, Jiazhi;
Zhang, Cheng;
Castillo, Nuria Codina;
Lalaurie, Christophe J;
Gao, Xin;
Dalby, Paul A;
Kozielski, Frank;
(2023)
Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH.
Scientific Reports
, 13
, Article 16281. 10.1038/s41598-023-42698-7.
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Uçan, Deniz;
Hales, John E;
Aoudjane, Samir;
Todd, Nathan;
Dalby, Paul A;
(2023)
Column-free optical deconvolution of intrinsic fluorescence for a monoclonal antibody and its product-related impurities.
Journal of Chromatography A
, 1711
, Article 464463. 10.1016/j.chroma.2023.464463.
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Van de Steen, Alexander;
Wilkinson, Henry C;
Dalby, Paul A;
Frank, Stefanie;
(2024)
Encapsulation of Transketolase into In Vitro-Assembled Protein Nanocompartments Improves Thermal Stability.
ACS Applied Biomaterials
, 7
(6)
pp. 3660-3674.
10.1021/acsabm.3c01153.
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Vaud, S;
Pearcy, N;
Hanževački, M;
Van Hagen, AMW;
Abdelrazig, S;
Safo, L;
Ehsaan, M;
... Bryan, SJ; + view all
(2021)
Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution.
Metabolic Engineering
10.1016/j.ymben.2021.07.001.
(In press).
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Wilkinson, HC;
Dalby, PA;
(2020)
Fine-tuning the activity and stability of an evolved enzyme active-site through non-canonical amino-acids.
The FEBS Journal
10.1111/febs.15560.
(In press).
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Wilkinson, HC;
Dalby, PA;
(2020)
The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation.
Scientific Reports
, 10
, Article 4148. 10.1038/s41598-020-61175-z.
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Wilkinson, HC;
Dalby, PA;
(2019)
Novel insights into transketolase activation by cofactor binding identifies two native species subpopulations.
Scientific Reports
, 9
, Article 16116. 10.1038/s41598-019-52647-y.
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Wood, VE;
Groves, K;
Cryar, A;
Quaglia, M;
Matejtschuk, P;
Dalby, PA;
(2020)
HDX and In Silico Docking Reveal that Excipients Stabilize G-CSF via a Combination of Preferential Exclusion and Specific Hotspot Interactions.
Molecular Pharmaceutics
, 17
(12)
pp. 4637-4651.
10.1021/acs.molpharmaceut.0c00877.
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Wood, VE;
Groves, K;
Wong, LM;
Kong, L;
Bird, C;
Wadhwa, M;
Quaglia, M;
... Dalby, PA; + view all
(2022)
Protein Engineering and HDX Identify Structural Regions of G-CSF Critical to Its Stability and Aggregation.
Molecular Pharmaceutics
, 19
(2)
pp. 616-629.
10.1021/acs.molpharmaceut.1c00754.
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Wood, Victoria E;
Kellerman, Mark-Adam;
Groves, Kate;
Quaglia, Milena;
Topp, Elizabeth M;
Matejtschuk, Paul;
Dalby, Paul A;
(2024)
Investigation of the Solid-State Interactions in Lyophilized Human G-CSF Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Molecular Pharmaceutics
, 21
(4)
pp. 1965-1976.
10.1021/acs.molpharmaceut.3c01211.
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Yu, Haoran;
Ma, Shuang;
Li, Yiwen;
Dalby, Paul A;
(2022)
Hot spots-making directed evolution easier.
Biotechnology Advances
, 56
, Article 107926. 10.1016/j.biotechadv.2022.107926.
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Yu, H;
Dalby, P;
(2018)
Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off.
Proceedings of the National Academy of Sciences of the United States of America
, 115
(52)
E12192-E12200.
10.1073/pnas.1812204115.
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Yu, H;
Dalby, PA;
(2018)
Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics.
Proceedings of the National Academy of Sciences of the United States of America
, 115
(47)
E11043-E11052.
10.1073/pnas.1810324115.
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Yu, H;
López, RIH;
Steadman, D;
Méndez-Sánchez, D;
Higson, S;
Cázares-Körner, A;
Sheppard, TD;
... Dalby, PA; + view all
(2020)
Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α‐hydroxyketones.
The FEBS Journal
, 287
(9)
pp. 1758-1776.
10.1111/febs.15108.
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Yu, H;
Yan, Y;
Zhang, C;
Dalby, PA;
(2017)
Two strategies to engineer flexible loops for improved enzyme thermostability.
Scientific Reports
, 7
, Article 41212. 10.1038/srep41212.
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Zhang, Cheng;
Berg, Adam;
Joe, Carina CD;
Dalby, Paul A;
Douglas, Alexander D;
(2023)
Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration.
NPJ Vaccines
, 8
(1)
, Article 85. 10.1038/s41541-023-00674-2.
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Zhang, Cheng;
Bye, Jordan W;
Lui, Lok H;
Zhang, Hongyu;
Hales, John;
Brocchini, Steve;
Curtis, Robin A;
(2023)
Enhanced Thermal Stability and Reduced Aggregation in an Antibody Fab Fragment at Elevated Concentrations.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.3c00081.
(In press).
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Zhang, Cheng;
Dalby, Paul Anthony;
(2023)
Assessing and Engineering Antibody Stability Using Experimental and Computational Methods.
Methods in Molecular Biology
, 2552
pp. 165-197.
10.1007/978-1-0716-2609-2_9.
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Zhang, Hongyu;
Dalby, Paul A;
(2022)
Stability Convergence in Antibody Coformulations.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.2c00534.
(In press).
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Zhang, C;
Codina, N;
Tang, J;
Yu, H;
Chakroun, N;
Kozielski, F;
Dalby, PA;
(2021)
Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation.
Computational and Structural Biotechnology Journal
, 19
pp. 2726-2741.
10.1016/j.csbj.2021.05.005.
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Zhang, C;
Samad, M;
Yu, H;
Chakroun, N;
Hilton, D;
Dalby, PA;
(2018)
Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment.
Molecular Pharmaceutics
, 15
(8)
pp. 3079-3092.
10.1021/acs.molpharmaceut.8b00186.
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Zhang, H;
Dalby, PA;
(2020)
Stability enhancement in a mAb and Fab coformulation.
Scientific Reports
, 10
, Article 21129. 10.1038/s41598-020-77989-w.
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Zhang, H;
Yang, Y;
Zhang, C;
Farid, SS;
Dalby, PA;
(2021)
Machine learning reveals hidden stability code in protein native fluorescence.
Computational and Structural Biotechnology Journal
, 19
pp. 2750-2760.
10.1016/j.csbj.2021.04.047.
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Book chapter
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Yu, H;
Dalby, PA;
(2020)
A beginner's guide to molecular dynamics simulations and the identification of cross-correlation networks for enzyme engineering.
In: Tawfik, DS, (ed.)
Enzyme Engineering and Evolution: General Methods.
(pp. 15-49).
Academic Press
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Working / discussion paper
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Codina, N;
Zhang, C;
Chakroun, N;
Dalby, PA;
(2019)
Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational design.
BioRxiv: Cold Spring Harbor, NY, USA.
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Conference item
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Dalby, P;
(2016)
Conformational protein structure shifts in aggregation prone conditions for MAb and Fab.
Presented at: UNSPECIFIED.
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Hooker, A;
Splevins, A;
Horrocks, P;
Dalby, P;
Farid, SS;
(2017)
An evaluation of the cGMP manufacturing process economics and high-throughput characterisation of Targeted Secretion Inhibitors.
Presented at: TOXINS 2017, Madrid, Spain.
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Poster
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Bradford, Hannah F;
Lalaurie, Christophe J;
God, Jayesh;
Gao, Xin;
Pericleous, Charis;
Perkins, Stephen J;
Britt, Hannah;
... McDonnell, Thomas CR; + view all
(2024)
Plasmin-Clipped Beta-2-Glycoprotein I: Novel Structures Lead to Increased Antibody Binding.
Presented at: 7th European Conference of Immunology, Dublin, Ireland.
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Thesis
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Affaticati, PE;
(2017)
Engineering Transketolase for Industrial Biotechnology.
Doctoral thesis , UCL (University College London).
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Hilton, DW;
(2016)
Elucidating the aggregation mechanisms of antibody fragments through biophysical analysis.
Doctoral thesis , UCL (University College London).
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Lee, W;
(2016)
Directed evolution of bovine enterokinase for high functional expression in E.coli.
Doctoral thesis , UCL (University College London).
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Mazzer, A;
(2016)
Understanding the Influence of Adsorption-Mediated Processes on Antibody Aggregation in Bioprocessing.
Doctoral thesis , UCL (University College London).
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Robinson, MJ;
(2016)
Investigating the relationship between forced degradation and long-term shelf life for biotherapeutics.
Doctoral thesis , UCL (University College London).
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