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Advancements in the co-formulation of biologic therapeutics

Chauhan, VM; Zhang, H; Dalby, PA; Aylott, JW; (2020) Advancements in the co-formulation of biologic therapeutics. Journal of Controlled Release , 327 pp. 397-405. 10.1016/j.jconrel.2020.08.013. Green open access

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Abstract

Biologic therapeutics are the medicines of the future and are destined to transform the approaches by which the causes and symptoms of diseases are cured and alleviated. These approaches will be accelerated through the development of novel strategies that target multiple pharmacologically active sites using a combination of different biologics, or mixtures of biologics and small molecule therapeutics. However, for this potential to be realised, advancements in co-formulation strategies for biologic therapeutics must be established. This review describes the current and emerging developments within this field and highlights the challenges and potential solutions, that will pave-the-way towards their clinical translation.

Type: Article
Title: Advancements in the co-formulation of biologic therapeutics
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jconrel.2020.08.013
Publisher version: https://doi.org/10.1016/j.jconrel.2020.08.013
Language: English
Additional information: © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Biologics, Co-formulation, Combination therapy, Nucleic acid, Protein, Synergistic benefit, Vaccine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10109088
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