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alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

Galman, JL; Steadman, D; Bacon, S; Morris, P; Smith, MEB; Ward, JM; Dalby, PA; (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 - 7610. 10.1039/c0cc02911d. Green open access

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Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

Type: Article
Title: alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c0cc02911d
Publisher version: http://dx.doi.org/10.1039/c0cc02911d
Language: English
Additional information: Galman, JL and Steadman, D and Bacon, S and Morris, P and Smith, MEB and Ward, JM and Dalby, PA and Hailes, HC (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 – 7610 Reproduced by permission of The Royal Society of Chemistry
Keywords: ESCHERICHIA-COLI TRANSKETOLASE, CARBON BOND FORMATION, BIOCATALYTIC SYNTHESIS, SUBSTRATE-SPECIFICITY, CATALYZED SYNTHESIS, DIRECTED EVOLUTION, AMINO-ALCOHOLS, TRANSAMINASE, REACTOR
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/168160
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