Galman, JL;
Steadman, D;
Bacon, S;
Morris, P;
Smith, MEB;
Ward, JM;
Dalby, PA;
Galman, JL;
Steadman, D;
Bacon, S;
Morris, P;
Smith, MEB;
Ward, JM;
Dalby, PA;
Hailes, HC;
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(2010)
alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes.
Chemical Communications
, 46
(40)
7608 - 7610.
10.1039/c0cc02911d.
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Abstract
Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.
| Type: |
Article
|
| Title: |
alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes |
| Open access status: |
An open access version is available from UCL Discovery |
| DOI: |
10.1039/c0cc02911d |
| Publisher version: |
http://dx.doi.org/10.1039/c0cc02911d |
| Language: |
English |
| Additional information: |
Galman, JL and Steadman, D and Bacon, S and Morris, P and Smith, MEB and Ward, JM and Dalby, PA and Hailes, HC (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 – 7610 Reproduced by permission of The Royal Society of Chemistry |
| Keywords: |
ESCHERICHIA-COLI TRANSKETOLASE, CARBON BOND FORMATION, BIOCATALYTIC SYNTHESIS, SUBSTRATE-SPECIFICITY, CATALYZED SYNTHESIS, DIRECTED EVOLUTION, AMINO-ALCOHOLS, TRANSAMINASE, REACTOR |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: |
https://discovery.ucl.ac.uk/id/eprint/168160 |
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