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Number of items: 69.
Article
Allen, BDW;
Hareram, MD;
Seastram, AC;
McBride, T;
Wirth, T;
Browne, DL;
Morrill, LC;
(2019)
Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals.
Organic Letters
, 21
(22)
pp. 9241-9246.
10.1021/acs.orglett.9b03652.
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Beck, AJ;
Reddy, VM;
Sulkin, T;
Browne, D;
(2022)
Management of severe and symptomatic primary hyperparathyroidism in the first trimester of unplanned pregnancy.
Endocrinology, Diabetes and Metabolism Case Reports
, 2022
(1)
pp. 1-4.
10.1530/EDM-21-0203.
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Bolt, Robert RA;
Leitch, Jamie A;
Jones, Andrew C;
Nicholson, William I;
Browne, Duncan L;
(2022)
Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis.
Chemical Society Reviews
, 13
pp. 5872-5883.
10.1039/d1cs00657f.
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Bolt, Robert RA;
Raby‐Buck, Sarah E;
Ingram, Katharine;
Leitch, Jamie A;
Browne, Duncan L;
(2022)
Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion.
Angewandte Chemie
10.1002/ange.202210508.
(In press).
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Bolt, Robert RA;
Smallman, Harry R;
Leitch, Jamie A;
Bluck, Gavin W;
Barreteau, Fabien;
Iosub, Andrei V;
Constable, David;
... Browne, Duncan L; + view all
(2024)
Solvent Minimized Synthesis of Amides by Reactive Extrusion.
Angewandte Chemie
, 136
(41)
, Article e202408315. 10.1002/ange.202408315.
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Bolt, Robert RA;
Smallman, Harry R;
Leitch, Jamie A;
Bluck, Gavin W;
Barreteau, Fabien;
Iosub, Andrei V;
Constable, David;
... Browne, Duncan L; + view all
(2024)
Solvent Minimized Synthesis of Amides by Reactive Extrusion.
Angewandte Chemie International Edition
10.1002/anie.202408315.
(In press).
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Cao, Q;
Howard, JL;
Crawford, DE;
James, SL;
Browne, DL;
(2018)
Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder.
Green Chemistry
, 20
(19)
pp. 4443-4447.
10.1039/c8gc02036a.
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Cao, Q;
Howard, JL;
Wheatley, E;
Browne, DL;
(2018)
Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling.
Angewandte Chemie
, 130
(35)
pp. 11509-11513.
10.1002/ange.201806480.
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Cao, Q;
Howard, JL;
Wheatley, E;
Browne, DL;
(2018)
Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling.
Angewandte Chemie: International Edition
, 57
(35)
pp. 11339-11343.
10.1002/anie.201806480.
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Cao, Q;
Nicholson, WI;
Jones, AC;
Browne, DL;
(2019)
Robust Buchwald-Hartwig amination enabled by ball-milling.
Organic and Biomolecular Chemistry
, 17
(7)
pp. 1722-1726.
10.1039/c8ob01781f.
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Cao, Q;
Stark, RT;
Fallis, IA;
Browne, DL;
(2019)
A Ball-Milling-Enabled Reformatsky Reaction.
ChemSusChem
, 12
(12)
pp. 2554-2557.
10.1002/cssc.201900886.
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Carden, JL;
Gierlichs, LJ;
Wass, DF;
Browne, DL;
Melen, RL;
(2018)
Unlocking the catalytic potential of tris(3,4,5-trifluorophenyl)borane with microwave irradiation.
ChemComm
, 55
(3)
pp. 318-321.
10.1039/c8cc09459d.
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Carvalho Ribeiro, Jhully Anne Barros;
Rodini Mattioli, Renan;
Browne, Duncan L;
Pastre, Julio C;
(2025)
Mechanochemical synthesis of phthalimides from
terpenes via tandem Diels-Alder cycloaddition and
iodine-mediated aromatization.
RSC Sustainability
10.1039/d5su00509d.
(In press).
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Cuccu, Federico;
Browne, Duncan L;
Porcheddu, Andrea;
(2023)
Ammonia Synthesis by Mechanochemistry.
ChemCatChem: The European Society Journal for Catalysis
, Article e202300762. 10.1002/cctc.202300762.
(In press).
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Ferreira, Lucas Coral;
De Souza Galaverna, Renan;
McBride, Tom;
Costa e Silva, Rodrigo;
Browne, Duncan L;
Pastre, Julio Cezar;
(2025)
Fast and scalable continuous flow synthesis of butenolides and coumarins.
Reaction Chemistry and Engineering
10.1039/d4re00567h.
(In press).
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Galaverna, R;
Fernandes, LP;
Browne, DL;
Pastre, JC;
(2019)
Continuous flow processing as a tool for the generation of terpene-derived monomer libraries.
Reaction Chemistry & Engineering
, 4
(2)
pp. 362-367.
10.1039/c8re00237a.
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Galaverna, R;
McBride, T;
Pastre, JC;
Browne, DL;
(2019)
Exploring the generation and use of acylketenes with continuous flow processes.
Reaction Chemistry & Engineering
, 4
(9)
pp. 1559-1564.
10.1039/c9re00072k.
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Groves, LM;
Schotten, C;
Beames, J;
Platts, JA;
Coles, SJ;
Horton, PN;
Browne, DL;
(2017)
From Ligand to Phosphor: Rapid, Machine-Assisted Synthesis of Substituted Iridium(III) Pyrazolate Complexes with Tuneable Luminescence.
Chemistry - A European Journal
, 23
(39)
pp. 9407-9418.
10.1002/chem.201701551.
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Hareram, Mishra Deepak;
El Gehani, Albara AMA;
Harnedy, James;
Seastram, Alex C;
Jones, Andrew C;
Burns, Matthew;
Wirth, Thomas;
... Morrill, Louis C; + view all
(2022)
Electrochemical Deconstructive Functionalization of Cycloalkanols via Alkoxy Radicals Enabled by Proton-Coupled Electron Transfer.
Organic Letters
, 24
(21)
pp. 3890-3895.
10.1021/acs.orglett.2c01552.
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Howard, JL;
Brand, MC;
Browne, DL;
(2018)
Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics.
Angewandte Chemie
, 130
(49)
pp. 16336-16340.
10.1002/ange.201810141.
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Howard, JL;
Brand, MC;
Browne, DL;
(2018)
Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics.
Angewandte Chemie
, 57
(49)
pp. 16104-16108.
10.1002/anie.201810141.
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Howard, JL;
Cao, Q;
Browne, DL;
(2018)
Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
Chemical Science
, 9
(12)
pp. 3080-3094.
10.1039/c7sc05371a.
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Howard, JL;
Nicholson, W;
Sagatov, Y;
Browne, DL;
(2017)
One-pot multistep mechanochemical synthesis of fluorinated pyrazolones.
Beilstein Journal of Organic Chemistry
, 13
pp. 1950-1956.
10.3762/bjoc.13.189.
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Howard, JL;
Sagatov, Y;
Browne, DL;
(2018)
Mechanochemical electrophilic fluorination of liquid beta-ketoesters.
Tetrahedron
, 74
(25)
pp. 3118-3123.
10.1016/j.tet.2017.11.066.
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Howard, JL;
Sagatov, Y;
Repusseau, L;
Schotten, C;
Browne, DL;
(2017)
Controlling reactivity through liquid assisted grinding: the curious case of mechanochemical fluorination.
Green Chemistry
, 19
(12)
pp. 2798-2802.
10.1039/c6gc03139k.
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Howard, JL;
Schotten, C;
Alston, ST;
Browne, DL;
(2016)
Preparation of difluoromethylthioethers through difluoromethylation of disulfides using TMS-CF2H.
Chemical Communications
, 52
(54)
pp. 8448-8451.
10.1039/c6cc02693a.
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Howard, JL;
Schotten, C;
Browne, DL;
(2017)
Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing.
Reaction Chemistry & Engineering
, 2
(3)
pp. 281-287.
10.1039/c7re00034k.
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Huang, Lin;
Qiu, Mengyu;
Chang, Zhihao;
Browne, Duncan L;
Huang, Jianhui;
(2024)
C–H activation-enabled synthesis of a piperazine-embedded azadibenzo[a,g]corannulene analogue.
Organic Chemistry Frontiers
, 11
(10)
pp. 2807-2814.
10.1039/d4qo00415a.
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Huang, Lin;
Wang, Qing;
Fu, Peng;
Sun, Yuzhu;
Xu, Jun;
Browne, Duncan L;
Huang, Jianhui;
(2024)
Extended Quinolizinium-Fused Corannulene Derivatives: Synthesis and Properties.
JACS Au
10.1021/jacsau.4c00105.
(In press).
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Jones, AC;
Nicholson, WI;
Leitch, JA;
Browne, DL;
(2021)
A Ball-Milling-Enabled Cross-Electrophile Coupling.
Organic Letters
, 23
(16)
pp. 6337-6341.
10.1021/acs.orglett.1c02096.
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Jones, AC;
Nicholson, WI;
Smallman, HR;
Browne, DL;
(2020)
A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling.
Organic Letters
, 22
(19)
pp. 7433-7438.
10.1021/acs.orglett.0c02418.
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Jones, Andrew C;
Leitch, Jamie A;
Raby-Buck, Sarah E;
Browne, Duncan L;
(2022)
Mechanochemical techniques for the activation and use of zero-valent metals in synthesis.
Nature Synthesis
, 1
pp. 763-775.
10.1038/s44160-022-00106-4.
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Jones, Andrew C;
Williams, Matthew TJ;
Morrill, Louis C;
Browne, Duncan L;
(2022)
Mechanical Activation of Zero-Valent Metal Reductants for Nickel-Catalyzed Cross-Electrophile Coupling.
ACS Catalysis
pp. 13681-13689.
10.1021/acscatal.2c03117.
(In press).
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Juergens, S;
Scalcon, V;
Estrada-Ortiz, N;
Folda, A;
Tonolo, F;
Jandl, C;
Browne, DL;
... Casini, A; + view all
(2017)
Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes.
Bioorganic & Medicinal Chemistry
, 25
(20)
pp. 5452-5460.
10.1016/j.bmc.2017.08.001.
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Laudadio, G;
Barmpoutsis, E;
Schotten, C;
Struik, L;
Govaerts, S;
Browne, DL;
Noel, T;
(2019)
Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols.
Journal of the American Chemical Society (JACS)
, 141
(14)
pp. 5664-5668.
10.1021/jacs.9b02266.
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Leitch, JA;
Richardson, P;
Browne, DL;
(2023)
Evolution of Solid Processing Methods in Continuous Flow Technology: Reactive Extrusion.
Chimia
, 77
(5)
pp. 339-345.
10.2533/chimia.2023.339.
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Leitch, JA;
Smallman, HR;
Browne, DL;
(2021)
Solvent-Minimized Synthesis of 4CzIPN and Related Organic Fluorophores via Ball Milling.
The Journal of Organic Chemistry
, 86
(20 14095)
pp. 14095-14101.
10.1021/acs.joc.1c01233.
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Leitch, JA;
Browne, DL;
(2021)
Mechanoredox Chemistry as an Emerging Strategy in Synthesis.
Chemistry: A European Journal
, 27
(38)
pp. 9721-9726.
10.1002/chem.202100348.
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Mattioli, Renan Rodini;
Santos, Camila Souza;
de Souza, Bruna Butke;
Branco, Pedro Dominguez;
Bolt, Robert RA;
Raby-Buck, Sarah E;
Cabral, Tadeu Luiz Gomes;
... Pastre, Julio C; + view all
(2025)
On the Valorisation of Chitin-Derived Furans by Milling.
ChemSusChem
, 18
(3)
, Article e202401584. 10.1002/cssc.202401584.
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Morvan, J;
McBride, T;
Curbet, I;
Colombel-Rouen, S;
Roisnel, T;
Crévisy, C;
Browne, DL;
(2021)
Continuous Flow Z‐stereoselective Olefin Metathesis: Development and Applications in the Synthesis of Pheromones and Macrocyclic Odorant Molecules.
Angewandte Chemie International Edition
, 133
(36)
pp. 19837-19842.
10.1002/anie.202106410.
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Morvan, J;
McBride, T;
Curbet, I;
Colombel‐Rouen, S;
Roisnel, T;
Crévisy, C;
Browne, DL;
(2021)
Continuous Flow Z-Stereoselective Olefin Metathesis: Development and Applications in the Synthesis of Pheromones and Macrocyclic Odorant Molecules.
Angewandte Chemie
, 133
(36)
pp. 19837-19842.
10.1002/ange.202106410.
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Nicholson, W;
Howard, JL;
Magri, G;
Seastram, AC;
Khan, A;
Bolt, RRA;
Morrill, LC;
... Browne, DL; + view all
(2021)
Ball-Milling-Enabled Reactivity of Manganese Metal**.
Angewandte Chemie International Edition
10.1002/anie.202108752.
(In press).
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Nicholson, WI;
Barreteau, F;
Leitch, JA;
Payne, R;
Priestley, I;
Godineau, E;
Battilocchio, C;
(2021)
Direct Amidation of Esters via Ball Milling.
Angewandte Chemie
, 133
(40)
pp. 22039-22045.
10.1002/ange.202106412.
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Nicholson, WI;
Barreteau, F;
Leitch, JA;
Payne, R;
Priestley, I;
Godineau, E;
Battilocchio, C;
(2021)
Direct Amidation of Esters via Ball Milling.
Angewandte Chemie: International Edition
, 60
(40)
pp. 21868-21874.
10.1002/anie.202106412.
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Nicholson, WI;
Howard, JL;
Magri, G;
Seastram, AC;
Khan, A;
Bolt, RRA;
Morrill, LC;
... Browne, DL; + view all
(2021)
Ball‐Milling‐Enabled Reactivity of Manganese Metal**.
Angewandte Chemie
10.1002/ange.202108752.
(In press).
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Nicholson, WI;
Seastram, AC;
Iqbal, SA;
Reed-Berendt, BG;
Morrill, LC;
Browne, DL;
(2020)
N‐Heterocyclic Carbene Acyl Anion Organocatalysis by Ball‐Milling.
ChemSusChem
, 13
(1)
pp. 131-135.
10.1002/cssc.201902346.
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Pastre, JC;
Murray, PRD;
Browne, DL;
Brancaglion, GA;
Galaverna, RS;
Pilli, RA;
Ley, SV;
(2020)
Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin.
ACS Omega
, 5
(29)
pp. 18472-18483.
10.1021/acsomega.0c02390.
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Patel, Calum;
André-Joyaux, Emy;
Leitch, Jamie A;
de Irujo-Labalde, Xabier Martínez;
Ibba, Francesco;
Struijs, Job;
Ellwanger, Mathias A;
... Gouverneur, Véronique; + view all
(2023)
Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF.
Science
, 381
(6655)
pp. 302-306.
10.1126/science.adi1557.
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Poh, J-S;
Browne, DL;
Ley, SV;
(2016)
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.
Reaction Chemistry & Engineering
, 1
(1)
pp. 101-105.
10.1039/c5re00082c.
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Poh, J-S;
Garcia-Ruiz, C;
Zuniga, A;
Meroni, F;
Blakemore, DC;
Browne, DL;
Ley, SV;
(2016)
Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.
Organic & Biomolecular Chemistry
, 14
(25)
pp. 5983-5991.
10.1039/c6ob00970k.
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Pontini, Lorenzo;
Leitch, Jamie A;
Browne, Duncan L;
(2023)
Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc(0).
Green Chemistry
10.1039/d3gc00649b.
(In press).
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Priestley, I;
Battilocchio, C;
Iosub, AV;
Barreteau, F;
Bluck, GW;
Ling, KB;
Ingram, K;
... Browne, DL; + view all
(2023)
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling.
Organic Process Research and Development
, 27
(2)
pp. 269-275.
10.1021/acs.oprd.2c00226.
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Priestley, Ian;
Battilocchio, Claudio;
Iosub, Andrei;
Barreteau, Fabien;
Bluck, Gavin W;
Ling, Kenneth B;
Ingram, Katharine;
... Browne, Duncan L; + view all
(2023)
Correction to “Safety Considerations and Proposed Workflow for Laboratory Scale Chemical Synthesis by Ball Milling”.
[Corrigendum].
Organic Process Research & Development
, 27
(6)
p. 1154.
10.1021/acs.oprd.3c00155.
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Raby-Buck, Sarah;
Devlin, Jonathan;
Gupta, Prachi;
Battilocchio, Claudio;
Baumann, Marcus;
Polyzos, Anastasios;
Slater, Anna G;
(2025)
Continuous Flow Chemistry for Molecular Synthesis.
Nature Reviews Methods Primers
, 5
, Article 44. 10.1038/s43586-025-00414-x.
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Raby-Buck, Sarah E;
Mattioli, Renan R;
Bolt, Robert RA;
Ingram, Katharine;
Pastre, Julio C;
Browne, Duncan L;
(2025)
Nickel-Catalyzed Cross-Coupling of Aryl Chlorides by Heated Mechanochemistry: Scalable Suzuki-Miyaura Reactions via Twin-Screw Extrusion.
JACS Au
(In press).
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Riley, W;
Jones, AC;
Singh, K;
Browne, D;
Stuart, AM;
(2021)
Accessing novel fluorinated heterocycles with the hypervalent fluoroiodane reagent by solution and mechanochemical synthesis.
Chemical Communications
10.1039/d1cc02587b.
(In press).
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Santos, Camila Souza;
Rodini Mattioli, Renan;
Soares Baptista, Julia;
Menezes da Silva, Vitor H;
Browne, Duncan L;
Pastre, Julio Cezar;
(2023)
Nitrogenated aromatics from chitin.
Green Chemistry
, 25
(13)
pp. 5059-5067.
10.1039/d3gc00272a.
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Schotten, C;
Howard, JL;
Jenkins, RL;
Codina, A;
Browne, DL;
(2018)
A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring.
Tetrahedron
, 74
(38)
pp. 5503-5509.
10.1016/j.tet.2018.05.070.
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Schotten, C;
Leist, LGT;
Semrau, AL;
Browne, DL;
(2018)
A machine-assisted approach for the preparation of follow-on pharmaceutical compound libraries.
Reaction Chemistry & Engineering
, 3
(2)
pp. 210-215.
10.1039/c8re00010g.
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Schotten, C;
Leprevost, SK;
Yong, LM;
Hughes, CE;
Harris, KDM;
Browne, DL;
(2020)
Comparison of the Thermal Stabilities of Diazonium Salts and Their Corresponding Triazenes.
Organic Process Research and Development
, 24
(10)
pp. 2336-2341.
10.1021/acs.oprd.0c00162.
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Schotten, C;
Plaza, D;
Manzini, S;
Nolan, SP;
Ley, SV;
Browne, DL;
Lapkin, A;
(2015)
Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride.
ACS Sustainable Chemistry & Engineering
, 3
(7)
pp. 1453-1459.
10.1021/acssuschemeng.5b00397.
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Smallman, Harry R;
Brancaglion, Guilherme A;
Pastre, Julio C;
Browne, Duncan L;
(2022)
Continuous Flow Generation of Acylketene Intermediates via Nitrogen Extrusion.
The Journal of Organic Chemistry
10.1021/acs.joc.2c01486.
(In press).
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Smallman, HR;
Leitch, JA;
McBride, T;
Ley, SV;
Browne, D;
(2021)
Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions.
Tetrahedron
, 93
, Article 132305. 10.1016/j.tet.2021.132305.
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Wilkins, LC;
Howard, JL;
Burger, S;
Frentzel-Beyme, L;
Browne, DL;
Melen, RL;
(2017)
Exploring Multistep Continuous-Flow Hydrosilylation Reactions Catalyzed by Tris(pentafluorophenyl) borane.
Advanced Synthesis & Catalysis
, 359
(15)
pp. 2580-2584.
10.1002/adsc.201700349.
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Williams, Matthew TJ;
Morrill, Louis C;
Browne, Duncan L;
(2023)
Nickel-Catalyzed Intramolecular Alkene Difunctionalization by Ball-Milling.
Advanced Synthesis and Catalysis
10.1002/adsc.202300188.
(In press).
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Williams, MTJ;
Morrill, LC;
Browne, DL;
(2022)
Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect?
ChemSusChem
, 15
(1)
, Article e202102157. 10.1002/cssc.202102157.
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Williams, MTJ;
Morrill, LC;
Browne, DL;
(2020)
Expedient Organocatalytic Aza-Morita–Baylis–Hillman Reaction through Ball-Milling.
ACS Sustainable Chemistry & Engineering
, 8
(48)
pp. 17876-17881.
10.1021/acssuschemeng.0c07320.
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Yin, J;
Stark, RT;
Fallis, IA;
Browne, DL;
(2020)
A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions.
The Journal of Organic Chemistry
, 85
(4)
pp. 2347-2354.
10.1021/acs.joc.9b02876.
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Yu, Cihang;
Leitch, Jamie A;
Gierlichs, Lukas;
Das, Sampurna;
Porch, Adrian;
Melen, Rebecca L;
Browne, Duncan L;
(2024)
Use of Microwave Dielectric Spectroscopy for the In Actu Assessment of Frustrated Lewis Pair Encounter Complexes.
Journal of the American Chemical Society
, 146
(29)
pp. 19809-19817.
10.1021/jacs.4c02736.
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