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Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

Howard, JL; Cao, Q; Browne, DL; (2018) Mechanochemistry as an emerging tool for molecular synthesis: what can it offer? Chemical Science , 9 (12) pp. 3080-3094. 10.1039/c7sc05371a. Green open access

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Abstract

Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with ‘direct’ comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.

Type: Article
Title: Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7sc05371a
Publisher version: https://doi.org/10.1039/c7sc05371a
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. See: https://creativecommons.org/licenses/by/3.0/
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, HETEROCYCLIC CARBENE COMPLEXES, SOLVENT-FREE CONDITIONS, MRI CONTRAST AGENTS, STIRRED BALL MILL, H BOND AMIDATION, ALDOL REACTION, (S)-PROLINE-CONTAINING DIPEPTIDES, BRIDGED TETRAAZAMACROCYCLES, ENERGY EFFICIENCY, ORTHO-ARYLATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10114343
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