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Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Cao, Q; Howard, JL; Crawford, DE; James, SL; Browne, DL; (2018) Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder. Green Chemistry , 20 (19) pp. 4443-4447. 10.1039/c8gc02036a. Green open access

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Abstract

A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.

Type: Article
Title: Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c8gc02036a
Publisher version: https://doi.org/10.1039/C8GC02036A
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. See: https://creativecommons.org/licenses/by/3.0/
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Green & Sustainable Science & Technology, Chemistry, Science & Technology - Other Topics, PHARMACEUTICAL CO-CRYSTALS, MECHANOCHEMICAL SYNTHESIS, BALL MILLS, SOLVENT, FRAMEWORKS, EXTRUSION, POLYMORPH, EFFICIENT, LIQUID, SCALE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10114332
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