Williams, MTJ;
Morrill, LC;
Browne, DL;
(2020)
Expedient Organocatalytic Aza-Morita–Baylis–Hillman Reaction through Ball-Milling.
ACS Sustainable Chemistry & Engineering
, 8
(48)
pp. 17876-17881.
10.1021/acssuschemeng.0c07320.
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Abstract
A ball-milling enabled tertiary amine catalyzed aza-Morita–Baylis–Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions.
| Type: | Article |
|---|---|
| Title: | Expedient Organocatalytic Aza-Morita–Baylis–Hillman Reaction through Ball-Milling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acssuschemeng.0c07320 |
| Publisher version: | https://doi.org/10.1021/acssuschemeng.0c07320 |
| Language: | English |
| Additional information: | This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| Keywords: | Mechanochemistry, Organocatalysis, Metal-free, Solvent-free, Reaction methodology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114824 |
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