Cao, Q;
Stark, RT;
Fallis, IA;
Browne, DL;
(2019)
A Ball-Milling-Enabled Reformatsky Reaction.
ChemSusChem
, 12
(12)
pp. 2554-2557.
10.1002/cssc.201900886.
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Abstract
An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39–82 % yield) and is effective irrespective of the initial morphology of the zinc source.
| Type: | Article |
|---|---|
| Title: | A Ball-Milling-Enabled Reformatsky Reaction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cssc.201900886 |
| Publisher version: | https://doi.org/10.1002/cssc.201900886 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Green & Sustainable Science & Technology, Chemistry, Science & Technology - Other Topics, ball milling, mechanochemistry, organozinc formation, reformatsky reaction, TERTIARY ALKYLZINC BROMIDES, BETA-AMINO ESTERS, ALPHA,BETA-UNSATURATED KETONES, MECHANOCHEMICAL SYNTHESIS, ORGANIC-SYNTHESIS, ENHANCED AIR, ZINC, POLYMORPH, REAGENTS, SOLVENT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114326 |
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