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A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring

Schotten, C; Howard, JL; Jenkins, RL; Codina, A; Browne, DL; (2018) A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring. Tetrahedron , 74 (38) pp. 5503-5509. 10.1016/j.tet.2018.05.070. Green open access

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Abstract

Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF2H after 105 min.

Type: Article
Title: A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tet.2018.05.070
Publisher version: http://dx.doi.org/10.1016/j.tet.2018.05.070
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Continuous flow, Flow NMR, Inline monitoring, Exotherm control, Space time yield
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10114374
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