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Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect?

Williams, MTJ; Morrill, LC; Browne, DL; (2022) Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect? ChemSusChem , 15 (1) , Article e202102157. 10.1002/cssc.202102157. Green open access

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Abstract

Ball mills input energy to samples by pulverising the contents of the jar. Each impact on the sample or wall of the jar results in an instantaneous transmission of energy in the form of a temperature and pressure increase (volume reduction). Conversely, enantioselective organocatalytic reactions proceed through perceived delicate and well-organised transition states. Does there exist a dichotomy in the idea of enantioselective mechanochemical organocatalysis? This Review provides a survey of the literature reporting the combination of organocatalytic reactions with mechanochemical ball milling conditions. Where possible, direct comparisons of stirred in solution, stirred neat and ball milled processes are drawn with a particular focus on control of stereoselectivity.

Type: Article
Title: Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cssc.202102157
Publisher version: https://doi.org/10.1002/cssc.202102157
Language: English
Additional information: © 2021 The Authors. ChemSusChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10137753
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