Huang, Lin;
Qiu, Mengyu;
Chang, Zhihao;
Browne, Duncan L;
Huang, Jianhui;
(2024)
C–H activation-enabled synthesis of a piperazine-embedded azadibenzo[a,g]corannulene analogue.
Organic Chemistry Frontiers
10.1039/d4qo00415a.
(In press).
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Abstract
A novel piperazine-embedded azadibenzo[a,g]corannulene analogue was synthesized by a four-step bottom-up synthesis, including a nucleophilic aromatic substitution (SNAr) and a palladium-catalyzed intramolecular C–H activation arylation as key steps. This intriguing molecule represents the first example of an azacorannulene analogue bearing a piperazine ring on its polycyclic skeleton. X-ray diffraction analysis reveals a Cs-symmetric deformed bowl-shaped structure and one-dimensional columnar packing through π–π interactions with slightly offset centres, attributed to the presence of two sp3 carbons on its polycyclic core.
| Type: | Article |
|---|---|
| Title: | C–H activation-enabled synthesis of a piperazine-embedded azadibenzo[a,g]corannulene analogue |
| DOI: | 10.1039/d4qo00415a |
| Publisher version: | https://doi.org/10.1039/d4qo00415a |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10192733 |
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