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Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

Cao, Q; Howard, JL; Wheatley, E; Browne, DL; (2018) Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling. Angewandte Chemie , 130 (35) pp. 11509-11513. 10.1002/ange.201806480. Green open access

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Abstract

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

Type: Article
Title: Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ange.201806480
Publisher version: https://doi.org/10.1002/anie.201806480
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: ball milling, mechanochemistry, organometallic, organozinc solventless reactions
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10114333
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