Cao, Q;
Howard, JL;
Wheatley, E;
Browne, DL;
(2018)
Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling.
Angewandte Chemie: International Edition
, 57
(35)
pp. 11339-11343.
10.1002/anie.201806480.
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Abstract
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.
| Type: | Article |
|---|---|
| Title: | Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/anie.201806480 |
| Publisher version: | https://doi.org/10.1002/anie.201806480 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | ball milling, mechanochemistry, organometallic, organozinc, solventless reactions |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113326 |
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