Poh, J-S;
Browne, DL;
Ley, SV;
(2016)
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.
Reaction Chemistry & Engineering
, 1
(1)
pp. 101-105.
10.1039/c5re00082c.
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Abstract
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
| Type: | Article |
|---|---|
| Title: | A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5re00082c |
| Publisher version: | http://dx.doi.org/10.1039/c5re00082c |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114378 |
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