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A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Poh, J-S; Browne, DL; Ley, SV; (2016) A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry & Engineering , 1 (1) pp. 101-105. 10.1039/c5re00082c. Green open access

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Abstract

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.

Type: Article
Title: A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c5re00082c
Publisher version: http://dx.doi.org/10.1039/c5re00082c
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10114378
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