Bolt, Robert RA;
Leitch, Jamie A;
Jones, Andrew C;
Nicholson, William I;
Browne, Duncan L;
(2022)
Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis.
Chemical Society Reviews
, 13
pp. 5872-5883.
10.1039/d1cs00657f.
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Abstract
Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free - or highly solvent-minimised - reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from "batch-mode" ball-milling to "flow-mode" reactive extrusion, using twin-screw extrusion.
| Type: | Article |
|---|---|
| Title: | Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d1cs00657f |
| Publisher version: | https://doi.org/10.1039/D2SC01538B |
| Language: | English |
| Additional information: | © The Royal Society of Chemistry 2022. This article is Open Access (http://creativecommons.org/licenses/by-nc/3.0/). |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10148172 |
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