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Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

Bolt, Robert RA; Leitch, Jamie A; Jones, Andrew C; Nicholson, William I; Browne, Duncan L; (2022) Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis. Chemical Society Reviews 10.1039/d1cs00657f. (In press). Green open access

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Abstract

Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free - or highly solvent-minimised - reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from "batch-mode" ball-milling to "flow-mode" reactive extrusion, using twin-screw extrusion.

Type: Article
Title: Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d1cs00657f
Publisher version: https://doi.org/10.1039/D2SC01538B
Language: English
Additional information: © The Royal Society of Chemistry 2022. This article is Open Access (http://creativecommons.org/licenses/by-nc/3.0/).
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10148172
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