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Number of items at this level: 154.

2025

Vindrola-Padros, C; Gilchrist, K; Braverman, S; Omar, R; Merivale, E; Hussenbux, A; Khanna, S; ... Yu, R; + view all Vindrola-Padros, C; Gilchrist, K; Braverman, S; Omar, R; Merivale, E; Hussenbux, A; Khanna, S; Renias-Zuva, P; McNally, N; Yu, R; - view fewer (2025) A mixed-methods study on the recruitment of patients from ethnic minority groups to clinical trials in a central London teaching hospital. Contemporary Clinical Trials Communications , 45 , Article 101475. 10.1016/j.conctc.2025.101475.

2024

Onuwaje, Itseoritseno (Itse); (2024) Development of Three-Dimensional In Vitro CNS Models to Evaluate Novel Natural Product-Derived Compounds for Alzheimer's Disease Treatment. Doctoral thesis (Ph.D), UCL (University College London).

Pinzi, Luca; Conze, Christian; Bisi, Nicolo; Torre, Gabriele Dalla; Soliman, Ahmed; Monteiro-Abreu, Nanci; Trushina, Nataliya I; ... Brandt, Roland; + view all Pinzi, Luca; Conze, Christian; Bisi, Nicolo; Torre, Gabriele Dalla; Soliman, Ahmed; Monteiro-Abreu, Nanci; Trushina, Nataliya I; Krusenbaum, Andrea; Dolouei, Maryam Khodaei; Hellwig, Andrea; Christodoulou, Michael S; Passarella, Daniele; Bakota, Lidia; Rastelli, Giulio; Brandt, Roland; - view fewer (2024) Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction. Nature Communications , 15 , Article 1679. 10.1038/s41467-024-45851-6.

Pocock, Jennifer; Vasilopoulou, Foteini; Svensson, Elina; Cosker, Katharina; (2024) Microglia and TREM2. Neuropharmacology , 257 , Article 110020. 10.1016/j.neuropharm.2024.110020.

2023

Bouton, Marie-Christine; Geiger, Margarethe; Sheffield, William P; Irving, James A; Lomas, David A; Song, Sihong; Satyanarayanan, Ritvik S; ... Lucas, Alexandra R; + view all Bouton, Marie-Christine; Geiger, Margarethe; Sheffield, William P; Irving, James A; Lomas, David A; Song, Sihong; Satyanarayanan, Ritvik S; Zhang, Liqiang; McFadden, Grant; Lucas, Alexandra R; - view fewer (2023) The under-appreciated world of the serpin family of serine proteinase inhibitors. EMBO Molecular Medicine , Article e17144. 10.15252/emmm.202217144.

Hayden, Lystra P; Hobbs, Brian D; Busch, Robert; Cho, Michael H; Liu, Ming; Lopes-Ramos, Camila M; Lomas, David A; ... DeMeo, Dawn L; + view all Hayden, Lystra P; Hobbs, Brian D; Busch, Robert; Cho, Michael H; Liu, Ming; Lopes-Ramos, Camila M; Lomas, David A; Bakke, Per; Gulsvik, Amund; Silverman, Edwin K; Crapo, James D; Beaty, Terri H; Laird, Nan M; Lange, Christoph; DeMeo, Dawn L; - view fewer (2023) X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. Respiratory Research , 24 (1) , Article 38. 10.1186/s12931-023-02337-1.

Perrodin, Catherine; Verzat, Colombine; Bendor, Daniel; (2023) Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication. eLife , 12 , Article RP86464. 10.7554/eLife.86464.2.

Raman, B; McCracken, C; Cassar, MP; Moss, AJ; Finnigan, L; Samat, AHA; Ogbole, G; ... Bandula, S; + view all Raman, B; McCracken, C; Cassar, MP; Moss, AJ; Finnigan, L; Samat, AHA; Ogbole, G; Tunnicliffe, EM; Alfaro-Almagro, F; Menke, R; Xie, C; Gleeson, F; Lukaschuk, E; Lamlum, H; McGlynn, K; Popescu, IA; Sanders, ZB; Saunders, LC; Piechnik, SK; Ferreira, VM; Nikolaidou, C; Rahman, NM; Ho, LP; Harris, VC; Shikotra, A; Singapuri, A; Pfeffer, P; Manisty, C; Kon, OM; Beggs, M; O'Regan, DP; Fuld, J; Weir-McCall, JR; Parekh, D; Steeds, R; Poinasamy, K; Cuthbertson, DJ; Kemp, GJ; Semple, MG; Horsley, A; Miller, CA; O'Brien, C; Shah, AM; Chiribiri, A; Leavy, OC; Richardson, M; Elneima, O; McAuley, HJC; Sereno, M; Saunders, RM; Houchen-Wolloff, L; Greening, NJ; Bolton, CE; Brown, JS; Choudhury, G; Diar Bakerly, N; Easom, N; Echevarria, C; Marks, M; Hurst, JR; Jones, MG; Wootton, DG; Chalder, T; Davies, MJ; De Soyza, A; Geddes, JR; Greenhalf, W; Howard, LS; Jacob, J; Man, WDC; Openshaw, PJM; Porter, JC; Rowland, MJ; Scott, JT; Singh, SJ; Thomas, DC; Toshner, M; Lewis, KE; Heaney, LG; Harrison, EM; Kerr, S; Docherty, AB; Lone, NI; Quint, J; Sheikh, A; Zheng, B; Jenkins, RG; Cox, E; Francis, S; Halling-Brown, M; Chalmers, JD; Greenwood, JP; Plein, S; Hughes, PJC; Thompson, AAR; Rowland-Jones, SL; Wild, JM; Kelly, M; Treibel, TA; Bandula, S; - view fewer (2023) Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. The Lancet Respiratory Medicine , 11 (11) pp. 1003-1019. 10.1016/S2213-2600(23)00262-X.

2022

Al-Hatimy, Fatima; Farooq, Abdulaziz; Al Abiad, Mohamad; Yerramsetti, Shilpi; Al-Nesf, Maryam Ali; Manickam, Chidambaram; Al-Thani, Mohammed H; ... Al-Maadheed, Mohammed; + view all Al-Hatimy, Fatima; Farooq, Abdulaziz; Al Abiad, Mohamad; Yerramsetti, Shilpi; Al-Nesf, Maryam Ali; Manickam, Chidambaram; Al-Thani, Mohammed H; Al-Khater, Al-Hareth; Samsam, Waseem; Mohamed-Ali, Vidya; Al-Maadheed, Mohammed; - view fewer (2022) A Retrospective Study of Non-Communicable Diseases amongst Blue-Collar Migrant Workers in Qatar. International Journal of Environmental Research and Public Health , 19 (4) , Article 2266. 10.3390/ijerph19042266.

Ghosh, AJ; Hobbs, BD; Moll, M; Saferali, A; Boueiz, A; Yun, JH; Sciurba, F; ... Hersh, CP; + view all Ghosh, AJ; Hobbs, BD; Moll, M; Saferali, A; Boueiz, A; Yun, JH; Sciurba, F; Barwick, L; Limper, AH; Flaherty, K; Criner, G; Brown, KK; Wise, R; Martinez, FJ; Lomas, D; Castaldi, PJ; Carey, VJ; DeMeo, DL; Cho, MH; Silverman, EK; Hersh, CP; - view fewer (2022) Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine , 205 (3) pp. 313-323. 10.1164/rccm.202106-1404OC.

Pranke, Iwona Maria; Chevalier, Benoit; Premchandar, Aiswarya; Baatallah, Nesrine; Tomaszewski, Kamil F; Bitam, Sara; Tondelier, Danielle; ... Edelman, Aleksander; + view all Pranke, Iwona Maria; Chevalier, Benoit; Premchandar, Aiswarya; Baatallah, Nesrine; Tomaszewski, Kamil F; Bitam, Sara; Tondelier, Danielle; Golec, Anita; Stolk, Jan; Lukacs, Gergely L; Hiemstra, Pieter S; Dadlez, Michal; Lomas, David A; Irving, James A; Delaunay-Moisan, Agnes; van Anken, Eelco; Hinzpeter, Alexandre; Sermet-Gaudelus, Isabelle; Edelman, Aleksander; - view fewer (2022) Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. Cellular and Molecular Life Sciences , 79 , Article 503. 10.1007/s00018-022-04528-3.

Soliman, Ahmed; Bakota, Lidia; Brandt, Roland; (2022) Microtubule-modulating Agents in the Fight Against Neurodegeneration: Will it ever Work? Current Neuropharmacology , 20 (4) pp. 782-798. 10.2174/1570159x19666211201101020.

Ullah, Ehsan; El-Menyar, Ayman; Kunji, Khalid; Elsousy, Reem; Mokhtar, Haira RB; Ahmad, Eiman; Al-Nesf, Maryam; ... Al Suwaidi, Jassim; + view all Ullah, Ehsan; El-Menyar, Ayman; Kunji, Khalid; Elsousy, Reem; Mokhtar, Haira RB; Ahmad, Eiman; Al-Nesf, Maryam; Beotra, Alka; Al-Maadheed, Mohammed; Mohamed-Ali, Vidya; Saad, Mohamad; Al Suwaidi, Jassim; - view fewer (2022) Untargeted Metabolomics Profiling Reveals Perturbations in Arginine-NO Metabolism in Middle Eastern Patients with Coronary Heart Disease. Metabolites , 12 (6) , Article 517. 10.3390/metabo12060517.

2021

Bafadhel, M; Barnes, N; Bourke, SC; Compton, C; Criner, GJ; Dransfield, MT; Halpin, DMG; ... Singh, D; + view all Bafadhel, M; Barnes, N; Bourke, SC; Compton, C; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MK; Hartley, B; Jones, CE; Lange, P; Lettis, S; Lipson, DA; Lomas, DA; Martin, N; Martinez, FJ; Wise, R; Singh, D; - view fewer (2021) A single blood eosinophil count measurement is as good as two for prediction of ICS treatment response in the IMPACT trial. European Respiratory Journal , 58 (3) , Article 2004522. 10.1183/13993003.04522-2020.

Bourdin, A; Criner, G; Devouassoux, G; Dransfield, M; Halpin, DMG; Han, MK; Jones, CE; ... Hanania, NA; + view all Bourdin, A; Criner, G; Devouassoux, G; Dransfield, M; Halpin, DMG; Han, MK; Jones, CE; Kalhan, R; Lange, P; Lettis, S; Lipson, DA; Lomas, DA; Maria-Tome, JME-S; Martin, N; Martinez, FJ; Quasny, H; Sail, L; Siler, TM; Singh, D; Thomashow, B; Watz, H; Wise, R; Hanania, NA; - view fewer (2021) InforMing the PAthway of COPD Treatment (IMPACT Trial) Single-Inhaler Triple Therapy (Fluticasone Furoate/Umeclidinium/Vilanterol) Versus Fluticasone Furoate/Vilanterol and Umeclidinium/Vilanterol in Patients With COPD: Analysis o the Western Europe and North America Regions. Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation , 8 (1) pp. 76-90. 10.15326/jcopdf.2020.0158.

Celli, B; Locantore, N; Yates, JC; Bakke, P; Calverley, PMA; Crim, C; Coxson, HO; ... Evaluation of COPD Longitudinally to Identify Predictive Surroga; + view all Celli, B; Locantore, N; Yates, JC; Bakke, P; Calverley, PMA; Crim, C; Coxson, HO; Lomas, DA; MacNee, W; Miller, BE; Mullerova, H; Rennard, SI; Silverman, EK; Wouters, E; Tal-Singer, R; Agusti, A; Vestbo, J; Evaluation of COPD Longitudinally to Identify Predictive Surroga; - view fewer (2021) Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort. European Respiratory Journal , 57 (3) , Article 2001339. 10.1183/13993003.01339-2020.

Engleitner, H; Jha, A; Herron, D; Nelson, A; Rees, G; McNally, N; Williams, B; Engleitner, H; Jha, A; Herron, D; Nelson, A; Rees, G; McNally, N; Williams, B; Nachev, P; - view fewer (2021) Enrolment in clinical research at UCLH and geographically distributed indices of deprivation [version 1; peer review: awaiting peer review]. Wellcome Open Research , 6 , Article 342. 10.12688/wellcomeopenres.17300.1.

Fromme, M; Schneider, CV; Pereira, V; Hamesch, K; Pons, M; Reichert, MC; Benini, F; ... Strnad, P; + view all Fromme, M; Schneider, CV; Pereira, V; Hamesch, K; Pons, M; Reichert, MC; Benini, F; Ellis, P; H Thorhauge, K; Mandorfer, M; Burbaum, B; Woditsch, V; Chorostowska-Wynimko, J; Verbeek, J; Nevens, F; Genesca, J; Miravitlles, M; Nuñez, A; Schaefer, B; Zoller, H; Janciauskiene, S; Abreu, N; Jasmins, L; Gaspar, R; Gomes, C; Schneider, KM; Trauner, M; Krag, A; Gooptu, B; Thorburn, D; Marshall, A; Hurst, JR; Lomas, DA; Lammert, F; Gaisa, NT; Clark, V; Griffiths, W; Trautwein, C; Turner, AM; McElvaney, NG; Strnad, P; - view fewer (2021) Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency. Gut 10.1136/gutjnl-2020-323729. (In press).

Gordon, C; Yardley, S; Lomas, DA; Edwards, SJL; (2021) Limitations to Contingency Measures: Reflections from COVID-19 Surges in the UK. The American Journal of Bioethics , 21 (8) pp. 31-34. 10.1080/15265161.2021.1940365.

Han, MK; Criner, GJ; Dransfield, MT; Halpin, DMG; Jones, CE; Kilbride, S; Lange, P; ... Singh, D; + view all Han, MK; Criner, GJ; Dransfield, MT; Halpin, DMG; Jones, CE; Kilbride, S; Lange, P; Lettis, S; Lipson, DA; Lomas, DA; Martin, N; Martinez, FJ; Wise, RA; Naya, IP; Singh, D; - view fewer (2021) Prognostic value of clinically important deterioration in COPD: IMPACT trial analysis. ERJ Open Research , 7 (1) , Article 00663-2020. 10.1183/23120541.00663-2020.

Hanania, NA; Mannino, DM; Criner, GJ; Dransfield, MT; Han, MK; Jones, CE; Kilbride, S; ... Lipson, DA; + view all Hanania, NA; Mannino, DM; Criner, GJ; Dransfield, MT; Han, MK; Jones, CE; Kilbride, S; Lomas, DA; Martin, N; Martinez, FJ; Singh, D; Wise, RA; Halpin, DMG; Lima, R; Lipson, DA; - view fewer (2021) Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. Chest , 159 (3) pp. 985-995. 10.1016/j.chest.2020.09.253.

Lakshman Kumar, P; Wilson, AC; Rocco, A; Cho, MH; Wan, E; Hobbs, BD; Washko, GR; ... McDonald, MLN; + view all Lakshman Kumar, P; Wilson, AC; Rocco, A; Cho, MH; Wan, E; Hobbs, BD; Washko, GR; Ortega, VE; Christenson, SA; Li, X; Wells, JM; Bhatt, SP; DeMeo, DL; Lutz, SM; Rossiter, H; Casaburi, R; Rennard, SI; Lomas, DA; Labaki, WW; Tal-Singer, R; Bowler, RP; Hersh, CP; Tiwari, HK; Dransfield, M; Thalacker-Mercer, A; Meyers, DA; Silverman, EK; McDonald, MLN; - view fewer (2021) Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. Journal of Cachexia, Sarcopenia and Muscle 10.1002/jcsm.12782. (In press).

Liddle, J; Pearce, AC; Arico-Muendel, C; Belyanskaya, S; Brewster, A; Brown, M; Chung, C-W; ... Lomas, DA; + view all Liddle, J; Pearce, AC; Arico-Muendel, C; Belyanskaya, S; Brewster, A; Brown, M; Chung, C-W; Denis, A; Dodic, N; Dossang, A; Eddershaw, P; Klimaszewska, D; Haq, I; Holmes, DS; Jagger, A; Jakhria, T; Jigorel, E; Lind, K; Messer, J; Neu, M; Olszewski, A; Ronzoni, R; Rowedder, J; Rüdiger, M; Skinner, S; Smith, KJ; Trottet, L; Uings, I; Zhu, Z; Irving, JA; Lomas, DA; - view fewer (2021) The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding. Bioorganic & Medicinal Chemistry Letters , 41 , Article 127973. 10.1016/j.bmcl.2021.127973.

Lomas, DA; Irving, JA; Arico-Muendel, C; Belyanskaya, S; Brewster, A; Brown, M; Chung, C-W; ... Pearce, AC; + view all Lomas, DA; Irving, JA; Arico-Muendel, C; Belyanskaya, S; Brewster, A; Brown, M; Chung, C-W; Dave, H; Denis, A; Dodic, N; Dossang, A; Eddershaw, P; Klimaszewska, D; Haq, I; Holmes, DS; Hutchinson, JP; Jagger, AM; Jakhria, T; Jigorel, E; Liddle, J; Lind, K; Marciniak, SJ; Messer, J; Neu, M; Olszewski, A; Ordonez, A; Ronzoni, R; Rowedder, J; Rüdiger, M; Skinner, S; Smith, KJ; Terry, R; Trottet, L; Uings, I; Wilson, S; Zhu, Z; Pearce, AC; - view fewer (2021) Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin. EMBO Molecular Medicine , Article e13167. 10.15252/emmm.202013167. (In press).

McKimpson, WM; Chen, Y; Irving, JA; Zheng, M; Weinberger, J; Tan, WLW; Tiang, Z; ... Kitsis, RN; + view all McKimpson, WM; Chen, Y; Irving, JA; Zheng, M; Weinberger, J; Tan, WLW; Tiang, Z; Jagger, AM; Chua, SC; Pessin, JE; Foo, RS-Y; Lomas, DA; Kitsis, RN; - view fewer (2021) Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes. Developmental Cell , 56 (6) 747-760.e6. 10.1016/j.devcel.2021.02.011.

Olszewska, DA; Fearon, C; McGuigan, C; McVeigh, TP; Houlden, H; Polke, JM; Lawlor, B; ... Lynch, T; + view all Olszewska, DA; Fearon, C; McGuigan, C; McVeigh, TP; Houlden, H; Polke, JM; Lawlor, B; Coen, R; Hutchinson, M; Hutton, M; Beausang, A; Delon, I; Brett, F; Sevastou, I; Seto-Salvia, N; de Silva, R; Lynch, T; - view fewer (2021) A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823-10G>T at the intron 9/exon 10 of the MAPT gene. Neurobiology of Aging , 106 343.e1-343.e8. 10.1016/j.neurobiolaging.2021.05.010.

Raccosta, S; Librizzi, F; Jagger, AM; Noto, R; Martorana, V; Lomas, DA; Irving, JA; Raccosta, S; Librizzi, F; Jagger, AM; Noto, R; Martorana, V; Lomas, DA; Irving, JA; Manno, M; - view fewer (2021) Scaling Concepts in Serpin Polymer Physics. Materials , 14 (10) , Article 2577. 10.3390/ma14102577.

Ronzoni, R; Ferrarotti, I; D’Acunto, E; Balderacchi, AM; Ottaviani, S; Lomas, DA; Irving, JA; ... Fra, A; + view all Ronzoni, R; Ferrarotti, I; D’Acunto, E; Balderacchi, AM; Ottaviani, S; Lomas, DA; Irving, JA; Miranda, E; Fra, A; - view fewer (2021) The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant. International Journal of Molecular Sciences , 22 (11) , Article 5668. 10.3390/ijms22115668.

Shipley, RJ; Brealey, D; Haniffa, R; Elwell, C; Baker, T; Lomas, DA; Singer, M; (2021) Lessons and risks of medical device deployment in a global pandemic. The Lancet Global Health 10.1016/S2214-109X(21)00028-0. (In press).

Singh, D; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MLK; Lange, P; Lettis, S; ... Lomas, D; + view all Singh, D; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MLK; Lange, P; Lettis, S; Lipson, DA; Mannino, D; Martin, N; Martinez, FJ; Miller, BE; Wise, R; Zhu, CQ; Lomas, D; - view fewer (2021) InforMing the PAthway of COPD Treatment (IMPACT) trial: fibrinogen levels predict risk of moderate or severe exacerbations. Respiratory Research , 22 (1) 10.1186/s12931-021-01706-y.

Smith, M; Abdesselem, HB; Mullins, M; Tan, T-M; Nel, AJM; Al-Nesf, MAY; Bensmail, I; ... Blackburn, JM; + view all Smith, M; Abdesselem, HB; Mullins, M; Tan, T-M; Nel, AJM; Al-Nesf, MAY; Bensmail, I; Majbour, NK; Vaikath, NN; Naik, A; Ouararhni, K; Mohamed-Ali, V; Al-Maadheed, M; Schell, DT; Baros-Steyl, SS; Anuar, ND; Ismail, NH; Morris, PE; Mamat, RNR; Rosli, NSM; Anwar, A; Ellan, K; Zain, RM; Burgers, WA; Mayne, ES; El-Agnaf, OMA; Blackburn, JM; - view fewer (2021) Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort. Viruses , 13 (5) , Article 786. 10.3390/v13050786.

Turner, CT; Brown, J; Shaw, E; Uddin, I; Tsaliki, E; Roe, JK; Pollara, G; ... Noursadeghi, M; + view all Turner, CT; Brown, J; Shaw, E; Uddin, I; Tsaliki, E; Roe, JK; Pollara, G; Sun, Y; Heather, JM; Lipman, M; Chain, B; Noursadeghi, M; - view fewer (2021) Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment. Frontiers Immunology , 12 , Article 634489. 10.3389/fimmu.2021.634489. (In press).

Vass, L; Fisk, M; Cheriyan, J; Mohan, D; Forman, J; Oseni, A; Devaraj, A; ... Wilkinson, IB; + view all Vass, L; Fisk, M; Cheriyan, J; Mohan, D; Forman, J; Oseni, A; Devaraj, A; Mäki-Petäjä, KM; McEniery, CM; Fuld, J; Hopkinson, NS; Lomas, DA; Cockcroft, JR; Tal-Singer, R; Polkey, MI; Wilkinson, IB; - view fewer (2021) Quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD. ERJ Open Research , 7 (3) , Article 00699-2020. 10.1183/23120541.00699-2020.

Yu, R; Hanley, B; Denegri, S; Ahmed, J; McNally, NJ; (2021) Evaluation of a patient and public involvement training programme for researchers at a large biomedical research centre in the UK. BMJ Open , 11 (8) , Article e047995. 10.1136/bmjopen-2020-047995.

2020

Abbas, SH; Pickett, E; Lomas, DA; Thorburn, D; Gooptu, B; Hurst, JR; Marshall, A; (2020) Non-invasive testing for liver pathology in alpha-1 antitrypsin deficiency. BMJ Open Respiratory Research , 7 (1) , Article e000820. 10.1136/bmjresp-2020-000820.

Day, NC; Kumar, S; Criner, G; Dransfield, M; Halpin, DMG; Han, MK; Jones, CE; ... Lipson, DA; + view all Day, NC; Kumar, S; Criner, G; Dransfield, M; Halpin, DMG; Han, MK; Jones, CE; Kaisermann, MC; Kilbride, S; Lange, P; Lomas, DA; Martin, N; Martinez, FJ; Singh, D; Wise, R; Lipson, DA; - view fewer (2020) Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial. Respiratory Research , 21 , Article 139. 10.1186/s12931-020-01398-w.

Dransfield, MT; Crim, C; Criner, GJ; Day, NC; Halpin, DMG; Han, MK; Jones, CE; ... Lange, P; + view all Dransfield, MT; Crim, C; Criner, GJ; Day, NC; Halpin, DMG; Han, MK; Jones, CE; Kilbride, S; LaFon, D; Lipson, DA; Lomas, DA; Martin, N; Martinez, FJ; Singh, D; Wise, RA; Lange, P; - view fewer (2020) Risk of Exacerbation and Pneumonia with Single Inhaler Triple Versus Dual Therapy in IMPACT. Annals of the American Thoracic Society 10.1513/AnnalsATS.202002-096OC. (In press).

Faull, SV; Elliston, ELK; Gooptu, B; Jagger, AM; Aldobiyan, I; Redzej, A; Badaoui, M; ... Lomas, DA; + view all Faull, SV; Elliston, ELK; Gooptu, B; Jagger, AM; Aldobiyan, I; Redzej, A; Badaoui, M; Heyer-Chauhan, N; Rashid, ST; Reynolds, GM; Adams, DH; Miranda, E; Orlova, EV; Irving, JA; Lomas, DA; - view fewer (2020) The structural basis for Z α₁-antitrypsin polymerization in the liver. Science Advances , 6 (43) , Article eabc1370. 10.1126/sciadv.abc1370.

Halpin, DMG; Criner, GJ; Dransfield, MT; Han, MK; Hartley, B; Harvey, C; Jones, CE; ... Lipson, DA; + view all Halpin, DMG; Criner, GJ; Dransfield, MT; Han, MK; Hartley, B; Harvey, C; Jones, CE; Kato, M; Lange, P; Lettis, S; Lomas, DA; Martinez, FJ; Martin, N; Singh, D; Wise, R; Zheng, J; Lipson, DA; - view fewer (2020) Triple Versus Dual Combination Therapy in Chronic Obstructive Pulmonary Disease in Asian Countries: Analysis of the IMPACT Trial. Pulmonary Therapy 10.1007/s41030-020-00136-3. (In press).

Halpin, DMG; Dransfield, MT; Han, MK; Jones, CE; Kilbride, S; Lange, P; Lipson, DA; ... Criner, GJ; + view all Halpin, DMG; Dransfield, MT; Han, MK; Jones, CE; Kilbride, S; Lange, P; Lipson, DA; Lomas, DA; Martinez, FJ; Pascoe, S; Singh, D; Wise, R; Criner, GJ; - view fewer (2020) The Effect of Exacerbation History on Outcomes in the IMPACT Trial. European Respiratory Journal , 55 , Article 1901921. 10.1183/13993003.01921-2019.

Han, MK; Criner, GJ; Dransfield, MT; Halpin, DMG; Jones, CE; Kilbride, S; Lange, P; ... Martinez, FJ; + view all Han, MK; Criner, GJ; Dransfield, MT; Halpin, DMG; Jones, CE; Kilbride, S; Lange, P; Lettis, S; Lipson, DA; Lomas, DA; Martin, N; Wise, RA; Singh, D; Martinez, FJ; - view fewer (2020) The Effect of ICS Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study: A Randomized, Double-blind Multicenter Trial. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201912-2478OC. (In press).

Jagger, AM; Waudby, CA; Irving, JA; Christodoulou, J; Lomas, DA; (2020) High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin. Nature Communications , 11 , Article 6371. 10.1038/s41467-020-20147-7.

Kurzawa-Akanbi, M; Keogh, M; Tsefou, E; Ramsay, L; Johnson, M; Keers, S; Ochieng, LWSA; ... Morris, CM; + view all Kurzawa-Akanbi, M; Keogh, M; Tsefou, E; Ramsay, L; Johnson, M; Keers, S; Ochieng, LWSA; McNair, A; Singh, P; Khan, A; Pyle, A; Hudson, G; Ince, PG; Attems, J; Burn, J; Chinnery, PF; Morris, CM; - view fewer (2020) Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress. Neuropathology and Applied Neurobiology 10.1111/nan.12634.

Laffranchi, M; Elliston, EL; Miranda, E; Perez, J; Ronzoni, R; Jagger, AM; Heyer-Chauhan, N; ... Irving, JA; + view all Laffranchi, M; Elliston, EL; Miranda, E; Perez, J; Ronzoni, R; Jagger, AM; Heyer-Chauhan, N; Brantly, ML; Fra, A; Lomas, DA; Irving, JA; - view fewer (2020) Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight , 5 (14) , Article e135459. 10.1172/jci.insight.135459.

Lipson, DA; Crim, C; Criner, GJ; Day, NC; Dransfield, MT; Halpin, DMG; Han, MK; ... Martinez, FJ; + view all Lipson, DA; Crim, C; Criner, GJ; Day, NC; Dransfield, MT; Halpin, DMG; Han, MK; Jones, CE; Kilbride, S; Lange, P; Lomas, DA; Lettis, S; Manchester, P; Martin, N; Midwinter, D; Morris, A; Pascoe, SJ; Singh, D; Wise, RA; Martinez, FJ; - view fewer (2020) Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201911-2207oc. (In press).

Murray, MJ; Bonilla-Medrano, NI; Lee, QL; Oxenford, SJ; Angell, R; Depledge, DP; Reeves, MB; (2020) Evasion of a human cytomegalovirus entry inhibitor with potent cysteine reactivity is concomitant with the utilisation of a heparan sulfate proteoglycan independent route of entry. Journal of Virology 10.1128/JVI.02012-19. (In press).

Ninou, I; Sevastou, I; Magkrioti, C; Kaffe, E; Stamatakis, G; Thivaios, S; Panayotou, G; ... Aidinis, V; + view all Ninou, I; Sevastou, I; Magkrioti, C; Kaffe, E; Stamatakis, G; Thivaios, S; Panayotou, G; Aoki, J; Kollias, G; Aidinis, V; - view fewer (2020) Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis. PLoS One , 15 (4) , Article e0226050. 10.1371/journal.pone.0226050.

Roberts, M; Sevastou, I; Imaizumi, Y; Mistry, K; Talma, S; Dey, M; Gartlon, J; ... de Silva, R; + view all Roberts, M; Sevastou, I; Imaizumi, Y; Mistry, K; Talma, S; Dey, M; Gartlon, J; Ochiai, H; Zhou, Z; Akasofu, S; Tokuhara, N; Ogo, M; Aoyama, M; Aoyagi, H; Strand, K; Sajedi, E; Agarwala, KL; Spidel, J; Albone, E; Horie, K; Staddon, JM; de Silva, R; - view fewer (2020) Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease. Acta Neuropathologica Communications , 8 , Article 13. 10.1186/s40478-020-0884-2.

Ronzoni, R; Heyer‐Chauhan, N; Fra, A; Pearce, AC; Rüdiger, M; Miranda, E; Irving, JA; Ronzoni, R; Heyer‐Chauhan, N; Fra, A; Pearce, AC; Rüdiger, M; Miranda, E; Irving, JA; Lomas, DA; - view fewer (2020) The molecular species responsible for α₁‐antitrypsin deficiency are suppressed by a small molecule chaperone. The FEBS Journal 10.1111/febs.15597. (In press).

Sampson, D; Yager, TD; Fox, B; Shallcross, L; McHugh, L; Seldon, T; Rapisarda, A; ... Noursadeghi, M; + view all Sampson, D; Yager, TD; Fox, B; Shallcross, L; McHugh, L; Seldon, T; Rapisarda, A; Brandon, RB; Navalkar, K; Simpson, N; Stafford, S; Gil, E; Venturini, C; Tsaliki, E; Roe, J; Chain, B; Noursadeghi, M; - view fewer (2020) Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study. BMC Medicine , 18 (1) 10.1186/s12916-020-01653-3.

Singer, M; Shipley, R; Baker, T; Cowell, A; Brealey, D; Lomas, D; (2020) The UCL Ventura CPAP device for COVID-19. The Lancet Respiratory Medicine , 8 (11) pp. 1076-1078. 10.1016/S2213-2600(20)30422-7.

Strnad, P; McElvaney, NG; Lomas, DA; (2020) Alpha₁-Antitrypsin Deficiency. The New England Journal of Medicine , 382 (15) pp. 1443-1455. 10.1056/NEJMra1910234.

Tabberer, M; Jones, CE; Kilbride, S; Halpin, DMG; Lomas, DA; Pascoe, S; Singh, D; ... Lipson, DA; + view all Tabberer, M; Jones, CE; Kilbride, S; Halpin, DMG; Lomas, DA; Pascoe, S; Singh, D; Wise, RA; Criner, GJ; Lange, P; Dransfield, MT; Han, MK; Martinez, FJ; Kaisermann, MC; Lipson, DA; - view fewer (2020) Single-Inhaler Triple Therapy and Health-Related Quality of Life in COPD: The IMPACT Study. Advances in Therapy 10.1007/s12325-020-01409-8. (In press).

Turner, CT; Gupta, RK; Tsaliki, E; Roe, JK; Mondal, P; Nyawo, GR; Palmer, Z; ... Noursadeghi, M; + view all Turner, CT; Gupta, RK; Tsaliki, E; Roe, JK; Mondal, P; Nyawo, GR; Palmer, Z; Miller, RF; Reeve, BW; Theron, G; Noursadeghi, M; - view fewer (2020) Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study. The Lancet Respiratory Medicine 10.1016/S2213-2600(19)30469-2. (In press).

Wilson, AC; Kumar, PL; Lee, S; Parker, MM; Arora, I; Morrow, JD; Wouters, EFM; ... McDonald, M-LN; + view all Wilson, AC; Kumar, PL; Lee, S; Parker, MM; Arora, I; Morrow, JD; Wouters, EFM; Casaburi, R; Rennard, SI; Lomas, DA; Agusti, A; Tal-Singer, R; Dransfield, MT; Wells, JM; Bhatt, SP; Washko, G; Thannickal, VJ; Tiwari, HK; Hersh, CP; Castaldi, PJ; Silverman, EK; McDonald, M-LN; - view fewer (2020) Heme metabolism genes Downregulated in COPD Cachexia. Respiratory , 21 , Article 100. 10.1186/s12931-020-01336-w.

Wilson, J; Herron, D; Nachev, P; McNally, N; Williams, B; Rees, G; (2020) The Value of Data: Applying a Public Value Model to the English National Health Service. JMIR - Journal of Medical Internet Research , 22 (3) , Article e15816. 10.2196/15816.

2019

Birgisdottir, AB; Mouilleron, S; Bhujabal, Z; Wirth, M; Sjottem, E; Evjen, G; Zhang, W; ... Johansen, T; + view all Birgisdottir, AB; Mouilleron, S; Bhujabal, Z; Wirth, M; Sjottem, E; Evjen, G; Zhang, W; Lee, R; O'Reilly, N; Tooze, SA; Lamark, T; Johansen, T; - view fewer (2019) Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy , 15 (8) pp. 1333-1355. 10.1080/15548627.2019.1581009.

Faravelli, G; Raimondi, S; Marchese, L; Partridge, FA; Soria, C; Mangione, PP; Canetti, D; ... Giorgetti, S; + view all Faravelli, G; Raimondi, S; Marchese, L; Partridge, FA; Soria, C; Mangione, PP; Canetti, D; Perni, M; Aprile, FA; Zorzoli, I; Di Schiavi, E; Lomas, DA; Bellotti, V; Sattelle, DB; Giorgetti, S; - view fewer (2019) C. elegans expressing D76N β_{2}-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Scientific Reports , 9 , Article 19960. 10.1038/s41598-019-56498-5.

Haidari, G; Day, S; Wood, M; Ridgers, H; Cope, A; Fleck, S; Yan, C; ... Shattock, RJ; + view all Haidari, G; Day, S; Wood, M; Ridgers, H; Cope, A; Fleck, S; Yan, C; Reijonen, K; Hannaman, D; Spentzou, A; Hayes, P; Vogt, A; Combadiere, B; Cook, A; McCormack, S; Shattock, RJ; - view fewer (2019) The Safety and Immunogenicity of GTU (R) MultiHIV DNA Vaccine Delivered by Transcutaneous and Intramuscular Injection With or Without Electroporation in HIV-1 Positive Subjects on Suppressive ART. Frontiers in Immunology , 10 , Article 2911. 10.3389/fimmu.2019.02911.

Hamid, S; Donaldson, IA; Hu, Y; Rodell, R; Villarini, B; Bonmati, E; Tranter, P; ... Ahmed, HU; + view all Hamid, S; Donaldson, IA; Hu, Y; Rodell, R; Villarini, B; Bonmati, E; Tranter, P; Punwani, S; Sidhu, HS; Willis, S; van der Meulen, J; Hawkes, D; McCartan, N; Potyka, I; Williams, NR; Brew-Graves, C; Freeman, A; Moore, CM; Barratt, D; Emberton, M; Ahmed, HU; - view fewer (2019) The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-fusion Targeted Biopsies for Prostate Cancer Risk Stratification. European Urology , 75 (5) pp. 733-740. 10.1016/j.eururo.2018.08.007.

Hartley, B; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MK; Jones, CE; Kilbride, S; ... Lettis, S; + view all Hartley, B; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MK; Jones, CE; Kilbride, S; Lange, P; Lipson, DA; Lomas, DA; Martin, N; Martinez, FJ; Singh, D; Wise, RA; Lettis, S; - view fewer (2019) Misinterpretation of time-to-first event curves can lead to inappropriate treatment. [Letter]. European Respiratory Journal , 54 (3) , Article 1900634. 10.1183/13993003.00634-2019.

Ismaila, AS; Risebrough, N; Schroeder, M; Shah, D; Martin, A; Goodall, EC; Ndirangu, K; ... Lomas, DA; + view all Ismaila, AS; Risebrough, N; Schroeder, M; Shah, D; Martin, A; Goodall, EC; Ndirangu, K; Criner, G; Dransfield, M; Halpin, DM; Han, MK; Lomas, DA; - view fewer (2019) Cost-Effectiveness Of Once-Daily Single-Inhaler Triple Therapy In COPD: The IMPACT Trial. International Journal of Chronic Obstructive Pulmonary Disease , 14 pp. 2681-2695. 10.2147/COPD.S216072.

Laffranchi, M; Elliston, ELK; Gangemi, F; Berardelli, R; Lomas, DA; Irving, JA; Fra, A; (2019) Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population. PLoS One , 14 (1) , Article e0206955. 10.1371/journal.pone.0206955.

Lutz, SM; Frederiksen, B; Begum, F; McDonald, M-L; Cho, MH; Hobbs, B; Parker, MM; ... Hokanson, JE; + view all Lutz, SM; Frederiksen, B; Begum, F; McDonald, M-L; Cho, MH; Hobbs, B; Parker, MM; DeMeo, DL; Hersh, CP; Eringher, M; Young, K; Jiang, L; Foreman, MG; Kinney, GL; Make, BJ; Lomas, DA; Bakke, P; Gulsvik, A; Crapo, JD; Silverman, EK; Beaty, TH; Hokanson, JE; - view fewer (2019) Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine & Tobacco Research , 21 (6) pp. 714-722. 10.1093/ntr/nty095.

Malintan, NT; Buckingham, SD; Lomas, DA; Sattelle, DB; (2019) Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin. Scientific Reports , 9 , Article 17293. 10.1038/s41598-019-53535-1.

Mazzon, M; Ortega-Prieto, AM; Imrie, D; Luft, C; Hess, L; Czieso, S; Grove, J; ... Marsh, M; + view all Mazzon, M; Ortega-Prieto, AM; Imrie, D; Luft, C; Hess, L; Czieso, S; Grove, J; Skelton, JK; Farleigh, L; Bugert, JJ; Wright, E; Temperton, N; Angell, R; Oxenford, S; Jacobs, M; Ketteler, R; Dorner, M; Marsh, M; - view fewer (2019) Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry. Viruses , 11 (2) , Article 176. 10.3390/v11020176.

McDonald, M-LN; Wouters, EFM; Rutten, E; Casaburi, R; Rennard, SI; Lomas, DA; Bamman, M; ... Silverman, EK; + view all McDonald, M-LN; Wouters, EFM; Rutten, E; Casaburi, R; Rennard, SI; Lomas, DA; Bamman, M; Celli, B; Agusti, A; Tal-Singer, R; Hersh, CP; Dransfield, M; Silverman, EK; - view fewer (2019) It’s more than low BMI: prevalence of cachexia and associated mortality in COPD. Respiratory Research , 20 (1) , Article 100. 10.1186/s12931-019-1073-3.

Nachev, P; Herron, D; McNally, N; Rees, G; Williams, B; (2019) Redefining the research hospital. npj Digital Medicine , 2 , Article 119. 10.1038/s41746-019-0201-2.

Nadai, Y; Held, K; Joseph, S; Ahmed, MIM; Hoffmann, VS; Peterhoff, D; Missange, M; ... Geldmacher, C; + view all Nadai, Y; Held, K; Joseph, S; Ahmed, MIM; Hoffmann, VS; Peterhoff, D; Missange, M; Bauer, A; Joachim, A; Reimer, U; Zerweck, J; McCormack, S; Cope, A; Tatoud, R; Shattock, RJ; Robb, ML; Sandstroem, EG; Hoelscher, M; Maboko, L; Bakari, M; Kroidl, A; Wagner, R; Weber, J; Pollakis, G; Geldmacher, C; - view fewer (2019) Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence. Frontiers in Immunology , 10 , Article 717. 10.3389/fimmu.2019.00717.

Pascoe, S; Barnes, N; Brusselle, G; Compton, C; Criner, GJ; Dransfield, MT; Halpin, DMG; ... Singh, D; + view all Pascoe, S; Barnes, N; Brusselle, G; Compton, C; Criner, GJ; Dransfield, MT; Halpin, DMG; Han, MK; Hartley, B; Lange, P; Lettis, S; Lipson, DA; Lomas, D; Martinez, FJ; Papi, A; Roche, N; Van der Valk, RJP; Wise, R; Singh, D; - view fewer (2019) Blood eosinophils and treatment response with triple and dual combination therapy in COPD: analysis of the IMPACT trial. The Lancet Respiratory Medicine , 7 (9) pp. 745-756. 10.1016/S2213-2600(19)30190-0.

Perocheau, D; Cunningham, S; Lee, J; Antinao Diaz, J; Waddington, SN; Gilmour, K; Eaglestone, S; ... Baruteau, J; + view all Perocheau, D; Cunningham, S; Lee, J; Antinao Diaz, J; Waddington, SN; Gilmour, K; Eaglestone, S; Lisowski, L; Thrasher, AJ; Alexander, IE; Gissen, P; Baruteau, J; - view fewer (2019) Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort. Human Gene Therapy , 30 (1) pp. 79-87. 10.1089/hum.2018.098.

Piers, TM; Cosker, K; Mallach, A; Johnson, GT; Guerreiro, R; Hardy, J; Pocock, JM; (2019) A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB Journal 10.1096/fj.201902447R.

Riccio, F; Talapatra, SK; Oxenford, S; Angell, R; Mazzon, M; Kozielski, F; (2019) Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biology Open , 8 , Article bio037663. 10.1242/bio.037663.

Sakornsakolpat, P; Prokopenko, D; Lamontagne, M; Reeve, NF; Guyatt, AL; Jackson, VE; Shrine, N; ... International COPD Genetics Consortium; + view all Sakornsakolpat, P; Prokopenko, D; Lamontagne, M; Reeve, NF; Guyatt, AL; Jackson, VE; Shrine, N; Qiao, D; Bartz, TM; Kim, DK; Lee, MK; Latourelle, JC; Li, X; Morrow, JD; Obeidat, M; Wyss, AB; Bakke, P; Barr, RG; Beaty, TH; Belinsky, SA; Brusselle, GG; Crapo, JD; de Jong, K; DeMeo, DL; Fingerlin, TE; Gharib, SA; Gulsvik, A; Hall, IP; Hokanson, JE; Kim, WJ; Lomas, DA; London, SJ; Meyers, DA; O'Connor, GT; Rennard, SI; Schwartz, DA; Sliwinski, P; Sparrow, D; Strachan, DP; Tal-Singer, R; Tesfaigzi, Y; Vestbo, J; Vonk, JM; Yim, JJ; Zhou, X; Bossé, Y; Manichaikul, A; Lahousse, L; Silverman, EK; Boezen, HM; Wain, LV; Tobin, MD; Hobbs, BD; Cho, MH; International COPD Genetics Consortium; - view fewer (2019) Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations. Nature Genetics , 51 pp. 494-505. 10.1038/s41588-018-0342-2.

Shao, Y; Forster, SC; Tsaliki, E; Vervier, K; Strang, A; Simpson, N; Kumar, N; ... Lawley, TD; + view all Shao, Y; Forster, SC; Tsaliki, E; Vervier, K; Strang, A; Simpson, N; Kumar, N; Stares, MD; Rodger, A; Brocklehurst, P; Field, N; Lawley, TD; - view fewer (2019) Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature , 574 pp. 117-121. 10.1038/s41586-019-1560-1.

Tran, M; Neves, J; Stamati, K; Redondo, P; Cope, A; Brew-Graves, C; Williams, N; ... Emberton, M; + view all Tran, M; Neves, J; Stamati, K; Redondo, P; Cope, A; Brew-Graves, C; Williams, N; Grierson, J; Cheema, U; Loizidou, M; Emberton, M; - view fewer (2019) Acceptability and feasibility study of patient-specific ‘tumouroids’ as personalised treatment screening tools: protocol for prospective tissue and data collection of participants with confirmed or suspected renal cell carcinoma. International Journal of Surgery Protocols , 14 pp. 24-29. 10.1016/j.isjp.2019.03.019.

Wirth, M; Zhang, W; Razi, M; Nyoni, L; Joshi, D; O'Reilly, N; Johansen, T; ... Mouilleron, S; + view all Wirth, M; Zhang, W; Razi, M; Nyoni, L; Joshi, D; O'Reilly, N; Johansen, T; Tooze, SA; Mouilleron, S; - view fewer (2019) Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nature Communications , 10 , Article 2055. 10.1038/s41467-019-10059-6.

2018

Bazzan, E; Tinè, M; Biondini, D; Benetti, R; Baraldo, S; Turato, G; Fagiuoli, S; ... Cosio, MG; + view all Bazzan, E; Tinè, M; Biondini, D; Benetti, R; Baraldo, S; Turato, G; Fagiuoli, S; Sonzogni, A; Rigobello, C; Rea, F; Calabrese, F; Foschino-Barbaro, MP; Miranda, E; Lomas, DA; Saetta, M; Cosio, MG; - view fewer (2018) α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency. Chest , 154 (3) pp. 607-616. 10.1016/j.chest.2018.04.039.

Cheeseman, HM; Day, S; McFarlane, L; Fleck, S; Miller, A; Cole, T; Sousa-Santos, N; ... Shattock, R; + view all Cheeseman, HM; Day, S; McFarlane, L; Fleck, S; Miller, A; Cole, T; Sousa-Santos, N; Cope, AV; Cizmeci, D; Tolazzi, M; Hwekwete, E; Hannaman, D; Kratochvil, S; McKay, P; Chung, A; Kent, S; Cook, A; Scarlatti, G; Abraham, S; Combadiere, B; McCormack, S; Lewis, D; Shattock, R; - view fewer (2018) Combined skin and muscle DNA priming provides enhanced humoral responses to an HIV-1 clade C envelope vaccine. Human Gene Therapy , 29 (9) pp. 1011-1028. 10.1089/hum.2018.075.

Elliston, ELK; Lomas, DA; Irving, JA; (2018) In Vitro Approaches for the Assessment of Serpin Polymerization. Methods in Molecular Biology , 1826 pp. 87-107. 10.1007/978-1-4939-8645-3_6.

Fisk, M; Cheriyan, J; Mohan, D; Forman, J; Mäki-Petäjä, KM; McEniery, CM; Fuld, J; ... Wilkinson, IB; + view all Fisk, M; Cheriyan, J; Mohan, D; Forman, J; Mäki-Petäjä, KM; McEniery, CM; Fuld, J; Rudd, JHF; Hopkinson, NS; Lomas, DA; Cockcroft, JR; Tal-Singer, R; Polkey, MI; Wilkinson, IB; - view fewer (2018) The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial. PLoS One , 13 (3) , Article e0194197. 10.1371/journal.pone.0194197.

Fisk, M; McEniery, CM; Gale, N; Mäki-Petäjä, K; Forman, JR; Munnery, M; Woodcock-Smith, J; ... ERICA Consortium and ACCT Investigators; + view all Fisk, M; McEniery, CM; Gale, N; Mäki-Petäjä, K; Forman, JR; Munnery, M; Woodcock-Smith, J; Cheriyan, J; Mohan, D; Fuld, J; Tal-Singer, R; Polkey, MI; Cockcroft, JR; Wilkinson, IB; ERICA Consortium and ACCT Investigators; - view fewer (2018) Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study. Hypertension , 71 (3) pp. 499-506. 10.1161/HYPERTENSIONAHA.117.10151.

Greene, CM; Marciniak, SJ; Teckman, J; Ferrarotti, I; Brantly, ML; Lomas, DA; Stoller, JK; Greene, CM; Marciniak, SJ; Teckman, J; Ferrarotti, I; Brantly, ML; Lomas, DA; Stoller, JK; McElvaney, NG; - view fewer (2018) Author Correction: α1-Antitrypsin deficiency. [Corrigendum]. Nature Reviews Disease Primers , 4 , Article 40. 10.1038/s41572-018-0043-2.

Halpin, DMG; Birk, R; Brealey, N; Criner, GJ; Dransfield, MT; Hilton, E; Lomas, DA; ... Lipson, DA; + view all Halpin, DMG; Birk, R; Brealey, N; Criner, GJ; Dransfield, MT; Hilton, E; Lomas, DA; Zhu, C-Q; Lipson, DA; - view fewer (2018) Single-inhaler triple therapy in symptomatic COPD patients: FULFIL subgroup analyses. ERJ Open Research , 4 (2) , Article 00119-2017. 10.1183/23120541.00119-2017.

Laffranchi, M; Berardelli, R; Ronzoni, R; Lomas, DA; Fra, A; (2018) Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity. Human Molecular Genetics , 27 (10) pp. 1785-1793. 10.1093/hmg/ddy090.

Lipson, DA; Barnacle, H; Birk, R; Brealey, N; Locantore, N; Lomas, DA; Ludwig-Sengpiel, A; ... Pascoe, SJ; + view all Lipson, DA; Barnacle, H; Birk, R; Brealey, N; Locantore, N; Lomas, DA; Ludwig-Sengpiel, A; Mohindra, R; Tabberer, M; Zhu, CQ; Pascoe, SJ; - view fewer (2018) Reply to Suissa and Ariel: The FULFIL Trial. American Journal of Respiratory and Critical Care Medicine , 197 (4) pp. 542-543. 10.1164/rccm.201709-1831LE.

Lipson, DA; Barnhart, F; Brealey, N; Brooks, J; Criner, GJ; Day, NC; Dransfield, MT; ... IMPACT Investigators; + view all Lipson, DA; Barnhart, F; Brealey, N; Brooks, J; Criner, GJ; Day, NC; Dransfield, MT; Halpin, DMG; Han, MK; Jones, CE; Kilbride, S; Lange, P; Lomas, DA; Martinez, FJ; Singh, D; Tabberer, M; Wise, RA; Pascoe, SJ; IMPACT Investigators; - view fewer (2018) Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. The New England Journal of Medicine , 378 (18) pp. 1671-1680. 10.1056/NEJMoa1713901.

Lomas, DA; (2018) New Therapeutic Targets for Alpha-1 Antitrypsin Deficiency. Chronic Obstructive Pulmonary Diseases , 5 (4) pp. 233-243. 10.15326/jcopdf.5.4.2017.0165.

Mohan, D; Forman, JR; Allinder, M; McEniery, CM; Bolton, CE; Cockcroft, JR; MacNee, W; ... Polkey, MI; + view all Mohan, D; Forman, JR; Allinder, M; McEniery, CM; Bolton, CE; Cockcroft, JR; MacNee, W; Fuld, J; Marchong, M; Gale, NS; Fisk, M; Nagarajan, S; Cheriyan, J; Lomas, DA; Calverley, PMA; Miller, BE; Tal-Singer, R; Wilkinson, IB; Polkey, MI; - view fewer (2018) Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. [Rapid communication]. Thorax , 73 (12) pp. 1182-1185. 10.1136/thoraxjnl-2018-211556.

Partridge, FA; Brown, AE; Buckingham, SD; Willis, NJ; Wynne, GM; Forman, R; Else, KJ; ... Sattelle, DB; + view all Partridge, FA; Brown, AE; Buckingham, SD; Willis, NJ; Wynne, GM; Forman, R; Else, KJ; Morrison, AA; Matthews, JB; Russell, AJ; Lomas, DA; Sattelle, DB; - view fewer (2018) An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes. International Journal for Parasitology: Drugs and Drug Resistance , 8 (1) pp. 8-21. 10.1016/j.ijpddr.2017.11.004.

Piers, TM; East, E; Villegas-Llerena, C; Sevastou, IG; Matarin, M; Hardy, J; Pocock, JM; (2018) Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity. Frontiers in Cellular Neuroscience , 12 , Article 404. 10.3389/fncel.2018.00404.

Qiao, D; Ameli, A; Prokopenko, D; Chen, H; Kho, AT; Parker, MM; Morrow, J; ... Cho, MH; + view all Qiao, D; Ameli, A; Prokopenko, D; Chen, H; Kho, AT; Parker, MM; Morrow, J; Hobbs, BD; Liu, Y; Beaty, TH; Crapo, JD; Barnes, KC; Nickerson, DA; Bamshad, M; Hersh, CP; Lomas, DA; Agusti, A; Make, BJ; Calverley, PMA; Donner, CF; Wouters, EF; Vestbo, J; Paré, PD; Levy, RD; Rennard, SI; Tal-Singer, R; Spitz, MR; Sharma, A; Ruczinski, I; Lange, C; Silverman, EK; Cho, MH; - view fewer (2018) Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Human Molecular Genetics , 27 (21) pp. 3801-3812. 10.1093/hmg/ddy269.

Segertiz, C; Rashid, T; Miguel, M; Serra Paola, M; Ordonez, A; Morell, C; Kaserman, J; ... Vallier, L; + view all Segertiz, C; Rashid, T; Miguel, M; Serra Paola, M; Ordonez, A; Morell, C; Kaserman, J; Madrigal, P; Hannan, N; Gatto, L; Tan, L; Wilson, A; Lilley, K; Marciniak, S; Gooptu, B; Lomas, DA; Vallier, L; - view fewer (2018) hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency. Journal of Hepatology , 69 (4) pp. 851-860. 10.1016/j.jhep.2018.05.028.

Tabberer, M; Lomas, DA; Birk, R; Brealey, N; Zhu, C-Q; Pascoe, S; Locantore, N; Tabberer, M; Lomas, DA; Birk, R; Brealey, N; Zhu, C-Q; Pascoe, S; Locantore, N; Lipson, DA; - view fewer (2018) Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life. Advances in Therapy , 35 (1) pp. 56-71. 10.1007/s12325-017-0650-4.

2017

Ansari, T; Lange, P; Southgate, A; Greco, K; Carvalho, C; Partington, L; Bullock, A; ... Birchall, MA; + view all Ansari, T; Lange, P; Southgate, A; Greco, K; Carvalho, C; Partington, L; Bullock, A; MacNeil, S; Lowdell, MW; Sibbons, PD; Birchall, MA; - view fewer (2017) Stem Cell-Based Tissue-Engineered Laryngeal Replacement. Stem Cells Translational Medicine , 6 (2) pp. 677-687. 10.5966/sctm.2016-0130.

Bailey, SR; Townsend, CL; Dent, H; Mallet, C; Tsaliki, E; Riley, EM; Noursadeghi, M; ... Field, N; + view all Bailey, SR; Townsend, CL; Dent, H; Mallet, C; Tsaliki, E; Riley, EM; Noursadeghi, M; Lawley, TD; Rodger, AJ; Brocklehurst, P; Field, N; - view fewer (2017) A pilot study to understand feasibility and acceptability of stool and cord blood sample collection for a large-scale longitudinal birth cohort. BMC Pregnancy Childbirth , 17 , Article 439. 10.1186/s12884-017-1627-7.

Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Ho, WSV; Jackson, SJ; ... Selwood, DL; + view all Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Ho, WSV; Jackson, SJ; Williams, TE; Al-Izki, S; Sevastou, I; Okuyama, M; Graier, WF; Stevenson, LA; Tanner, C; Ross, R; Pertwee, RG; Henstridge, CM; Irving, AJ; Schulman, J; Powell, K; Baker, MD; Giovannoni, G; Selwood, DL; - view fewer (2017) Big conductance calcium-activated potassium channel openers control spasticity without sedation. British Journal of Pharmacology , 174 (16) pp. 2662-2681. 10.1111/bph.13889.

Briggs, AH; Baker, T; Risebrough, NA; Chambers, M; Gonzalez-McQuire, S; Ismaila, AS; Exuzides, A; ... Lomas, DA; + view all Briggs, AH; Baker, T; Risebrough, NA; Chambers, M; Gonzalez-McQuire, S; Ismaila, AS; Exuzides, A; Colby, C; Tabberer, M; Muellerova, H; Locantore, N; Rutten-van Mölken, MPMH; Lomas, DA; - view fewer (2017) Development of the Galaxy Chronic Obstructive Pulmonary Disease (COPD) Model Using Data from ECLIPSE: Internal Validation of a Linked-Equations Cohort Model. Medical Decision Making , 37 (4) pp. 469-480. 10.1177/0272989X16653118.

Busch, R; Hobbs, BD; Zhou, J; Castaldi, PJ; McGeachie, MJ; Hardin, ME; Hawrylkiewicz, I; ... NETT Genetics, ECLIPSE, ICGN, and COPDGene Investigators, .; + view all Busch, R; Hobbs, BD; Zhou, J; Castaldi, PJ; McGeachie, MJ; Hardin, ME; Hawrylkiewicz, I; Sliwinski, P; Yim, JJ; Kim, WJ; Kim, DK; Agusti, A; Make, BJ; Crapo, JD; Calverley, PM; Donner, CF; Lomas, DA; Wouters, EF; Vestbo, J; Tal-Singer, R; Bakke, P; Gulsvik, A; Litonjua, AA; Sparrow, D; Paré, PD; Levy, RD; Rennard, SI; Beaty, TH; Hokanson, J; Silverman, EK; Cho, MH; NETT Genetics, ECLIPSE, ICGN, and COPDGene Investigators, .; - view fewer (2017) Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. American Journal of Respiratory Cell and Molecular Biology , 57 (1) pp. 35-46. 10.1165/rcmb.2016-0331OC.

Butler, CR; Hynds, RE; Crowley, C; Gowers, KH; Partington, L; Hamilton, NJ; Carvalho, C; ... Janes, SM; + view all Butler, CR; Hynds, RE; Crowley, C; Gowers, KH; Partington, L; Hamilton, NJ; Carvalho, C; Platé, M; Samuel, ER; Burns, AJ; Urbani, L; Birchall, MA; Lowdell, MW; De Coppi, P; Janes, SM; - view fewer (2017) Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds. Biomaterials , 124 pp. 95-105. 10.1016/j.biomaterials.2017.02.001.

Drewry, DH; Wells, CI; Andrews, DM; Angell, R; Al-Ali, H; Axtman, AD; Capuzzi, SJ; ... Willson, TM; + view all Drewry, DH; Wells, CI; Andrews, DM; Angell, R; Al-Ali, H; Axtman, AD; Capuzzi, SJ; Elkins, JM; Ettmayer, P; Frederiksen, M; Gileadi, O; Gray, N; Hooper, A; Knapp, S; Laufer, S; Luecking, U; Michaelides, M; Mueller, S; Muratov, E; Denny, RA; Saikatendu, KS; Treiber, DK; Zuercher, WJ; Willson, TM; - view fewer (2017) Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLOS ONE , 12 (8) , Article e0181585. 10.1371/journal.pone.0181585.

Elliott, MJ; Butler, CR; Varanou-Jenkins, A; Partington, L; Carvalho, C; Samuel, E; Crowley, C; ... Birchall, MA; + view all Elliott, MJ; Butler, CR; Varanou-Jenkins, A; Partington, L; Carvalho, C; Samuel, E; Crowley, C; Lange, P; Hamilton, NJ; Hynds, RE; Ansari, T; Sibbons, P; Fierens, A; McLaren, C; Roebuck, D; Wallis, C; Muthialu, N; Hewitt, R; Crabbe, D; Janes, SM; De Coppi, P; Lowdell, MW; Birchall, MA; - view fewer (2017) Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine. Stem Cells Translational Medicine , 6 (6) pp. 1458-1464. 10.1002/sctm.16-0443.

Haidari, G; Cope, A; Miller, A; Venables, S; Yan, C; Ridgers, H; Reijonen, K; ... Shattock, RJ; + view all Haidari, G; Cope, A; Miller, A; Venables, S; Yan, C; Ridgers, H; Reijonen, K; Hannaman, D; Spentzou, A; Hayes, P; Bouliotis, G; Vogt, A; Joseph, S; Combadiere, B; McCormack, S; Shattock, RJ; - view fewer (2017) Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial. Scientific Reports , 7 , Article 13011. 10.1038/s41598-017-13331-1.

Hardin, M; Cho, MH; Sharma, S; Glass, K; Castaldi, PJ; McDonald, M-L; Aschard, H; ... COPDGene and Evaluation of COPD Longitudinally to Identify Predi; + view all Hardin, M; Cho, MH; Sharma, S; Glass, K; Castaldi, PJ; McDonald, M-L; Aschard, H; Senter-Sylvia, J; Tantisira, K; Weiss, ST; Hersh, CP; Morrow, JD; Lomas, D; Agusti, A; Bakke, P; Gulsvik, A; O'Connor, GT; Dupuis, J; Hokanson, J; Crapo, JD; Beaty, TH; Laird, N; Silverman, EK; DeMeo, DL; COPDGene and Evaluation of COPD Longitudinally to Identify Predi; - view fewer (2017) Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. American Journal of Respiratory Cell and Molecular Biology , 56 (3) pp. 332-341. 10.1165/rcmb.2016-0172OC.

Hobbs, BD; de Jong, K; Lamontagne, M; Bossé, Y; Shrine, N; Artigas, MS; Wain, LV; ... International COPD Genetics Consortium, .; + view all Hobbs, BD; de Jong, K; Lamontagne, M; Bossé, Y; Shrine, N; Artigas, MS; Wain, LV; Hall, IP; Jackson, VE; Wyss, AB; London, SJ; North, KE; Franceschini, N; Strachan, DP; Beaty, TH; Hokanson, JE; Crapo, JD; Castaldi, PJ; Chase, RP; Bartz, TM; Heckbert, SR; Psaty, BM; Gharib, SA; Zanen, P; Lammers, JW; Oudkerk, M; Groen, HJ; Locantore, N; Tal-Singer, R; Rennard, SI; Vestbo, J; Timens, W; Paré, PD; Latourelle, JC; Dupuis, J; O'Connor, GT; Wilk, JB; Kim, WJ; Lee, MK; Oh, YM; Vonk, JM; de Koning, HJ; Leng, S; Belinsky, SA; Tesfaigzi, Y; Manichaikul, A; Wang, XQ; Rich, SS; Barr, RG; Sparrow, D; Litonjua, AA; Bakke, P; Gulsvik, A; Lahousse, L; Brusselle, GG; Stricker, BH; Uitterlinden, AG; Ampleford, EJ; Bleecker, ER; Woodruff, PG; Meyers, DA; Qiao, D; Lomas, DA; Yim, JJ; Kim, DK; Hawrylkiewicz, I; Sliwinski, P; Hardin, M; Fingerlin, TE; Schwartz, DA; Postma, DS; MacNee, W; Tobin, MD; Silverman, EK; Boezen, HM; Cho, MH; COPDGene Investigators, .; ECLIPSE Investigators, .; LifeLines Investigators, .; SPIROMICS Research Group, .; International COPD Genetics Network Investigators, .; UK BiLEVE Investigators, .; International COPD Genetics Consortium, .; - view fewer (2017) Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nature Genetics , 49 pp. 426-432. 10.1038/ng.3752.

Ishii, T; Angata, T; Wan, ES; Cho, MH; Motegi, T; Gao, C; Ohtsubo, K; ... Kida, K; + view all Ishii, T; Angata, T; Wan, ES; Cho, MH; Motegi, T; Gao, C; Ohtsubo, K; Kitazume, S; Gemma, A; ParÉ, PD; Lomas, DA; Silverman, EK; Taniguchi, N; Kida, K; - view fewer (2017) Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency. Respirology , 22 (4) pp. 684-690. 10.1111/resp.12952.

Kinsler, VA; O'Hare, P; Bulstrode, N; Calonje, JE; Chong, WK; Hargrave, D; Jacques, T; ... Slater, O; + view all Kinsler, VA; O'Hare, P; Bulstrode, N; Calonje, JE; Chong, WK; Hargrave, D; Jacques, T; Lomas, D; Sebire, NJ; Slater, O; - view fewer (2017) Melanoma in congenital melanocytic naevi. British Journal of Dermatology , 176 (5) pp. 1131-1143. 10.1111/bjd.15301.

Leeming, DJ; Byrjalsen, I; Sand, JMB; Bihlet, AR; Lange, P; Evaluation of COPD Longitudinally to Identify Surrogate Endpoint; Thal-Singer, R; ... Vestbo, J; + view all Leeming, DJ; Byrjalsen, I; Sand, JMB; Bihlet, AR; Lange, P; Evaluation of COPD Longitudinally to Identify Surrogate Endpoint; Thal-Singer, R; Miller, BE; Karsdal, MA; Vestbo, J; - view fewer (2017) Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study. BMC Pulmonary Medicine , 17 , Article 164. 10.1186/s12890-017-0505-4.

Lipson, DA; Barnacle, H; Birk, R; Brealey, N; Locantore, N; Lomas, DA; Ludwig-Sengpiel, A; ... Pascoe, SJ; + view all Lipson, DA; Barnacle, H; Birk, R; Brealey, N; Locantore, N; Lomas, DA; Ludwig-Sengpiel, A; Mohindra, R; Tabberer, M; Zhu, C-Q; Pascoe, SJ; - view fewer (2017) FULFIL Trial: Once-Daily Triple Therapy in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine , 196 (4) pp. 438-446. 10.1164/rccm.201703-0449OC.

McCormack, SMG; Joseph, S; Quinn, K; Greenwood, A; Cope, AV; McKay, PF; Hayes, PJ; ... Weber, J; + view all McCormack, SMG; Joseph, S; Quinn, K; Greenwood, A; Cope, AV; McKay, PF; Hayes, PJ; Kopycinski, JT; Miller, AN; Montefiori, DC; Dally, L; Bouliotis, G; Lewis, DJM; Tatoud, R; Wagner, R; Esteban, M; Shattock, RJ; McCormack, SMC; Weber, J; - view fewer (2017) A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, and Env gp 140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes. Frontiers in Immunology , 8 , Article 149. 10.3389/fimmu.2017.00149.

McDonald, M-LN; Won, S; Mattheisen, M; Castaldi, PJ; Cho, MH; Rutten, E; Hardin, M; ... Silverman, EK; + view all McDonald, M-LN; Won, S; Mattheisen, M; Castaldi, PJ; Cho, MH; Rutten, E; Hardin, M; Yip, W-K; Rennard, SI; Lomas, DA; Wouters, EFM; Agusti, A; Casaburi, R; Lange, CP; O'Connor, G; Hersh, CP; Silverman, EK; - view fewer (2017) Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. Journal of Cachexia, Sarcopenia and Muscle , 8 (3) pp. 428-436. 10.1002/jcsm.12171.

Miranda, E; Ferrarotti, I; Berardelli, R; Laffranchi, M; Cerea, M; Gangemi, F; Haq, I; ... Fra, A; + view all Miranda, E; Ferrarotti, I; Berardelli, R; Laffranchi, M; Cerea, M; Gangemi, F; Haq, I; Ottaviani, S; Lomas, DA; Irving, JA; Fra, A; - view fewer (2017) The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization. The FEBS Journal , 284 (13) pp. 2110-2126. 10.1111/febs.14111.

Sreenan, N; (2017) Ineradicable Humanity: Literary Responses to Darwin in Zola, Hardy, and the Utopian Novel. Doctoral thesis , UCL (University College London).

2016

Burton, EA; (2016) Extrastriate form and motion processing in cone dysfunction and normal vision. Doctoral thesis , UCL (University College London).

Chow, PS; (2016) ‘A Symptom of Something Real’: The Øresund Region on Film and Television, 1999–2014. Doctoral thesis , UCL (University College London).

Cosgrove, CA; Lacey, CJ; Cope, AV; Bartolf, A; Morris, G; Yan, C; Baden, S; ... Shattock, RJ; + view all Cosgrove, CA; Lacey, CJ; Cope, AV; Bartolf, A; Morris, G; Yan, C; Baden, S; Cole, T; Carter, D; Brodnicki, E; Shen, X; Joseph, S; DeRosa, SC; Peng, L; Yu, X; Ferrari, G; Seaman, M; Montefiori, DC; Frahm, N; Tomaras, GD; Stöhr, W; McCormack, S; Shattock, RJ; - view fewer (2016) Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study. PLoS One , 11 (5) , Article e0152038. 10.1371/journal.pone.0152038.

Dickens, JA; Ordonez, A; Chambers, JE; Beckett, AJ; Patel, V; Malzer, E; Dominicus, CS; ... Marciniak, SJ; + view all Dickens, JA; Ordonez, A; Chambers, JE; Beckett, AJ; Patel, V; Malzer, E; Dominicus, CS; Bradley, J; Peden, AA; Prior, IA; Lomas, DA; Marciniak, SJ; - view fewer (2016) The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-alpha(1)-antitrypsin. FASEB Journal , 30 (12) pp. 4083-4097. 10.1096/fj.201600430R.

Greene, CM; Marciniak, SJ; Teckman, J; Ferrarotti, I; Brantly, ML; Lomas, DA; Stoller, JK; Greene, CM; Marciniak, SJ; Teckman, J; Ferrarotti, I; Brantly, ML; Lomas, DA; Stoller, JK; McElvaney, NG; - view fewer (2016) α1-Antitrypsin deficiency. Nature Reviews Disease Primers , 2 , Article 16051. 10.1038/nrdp.2016.51.

Haq, I; Irving, JA; Saleh, AD; Dron, L; Regan-Mochrie, GL; Motamedi-Shad, N; Hurst, JR; ... Lomas, DA; + view all Haq, I; Irving, JA; Saleh, AD; Dron, L; Regan-Mochrie, GL; Motamedi-Shad, N; Hurst, JR; Gooptu, B; Lomas, DA; - view fewer (2016) Deficiency Mutations of α1-antitrypsin Differentially Affect Folding, Function and Polymerization. American Journal of Respiratory Cell and Molecular Biology , 54 (1) pp. 71-80. 10.1165/rcmb.2015-0154OC.

Khundakar, AA; Hanson, PS; Erskine, D; Lax, NZ; Roscamp, J; Karyka, E; Tsefou, E; ... Morris, CM; + view all Khundakar, AA; Hanson, PS; Erskine, D; Lax, NZ; Roscamp, J; Karyka, E; Tsefou, E; Singh, P; Cockell, SJ; Gribben, A; Ramsay, L; Blain, PG; Mosimann, UP; Lett, DJ; Elstner, M; Turnbull, DM; Xiang, CC; Brownstein, MJ; O'Brien, JT; Taylor, J-P; Attems, J; Thomas, AJ; McKeith, IG; Morris, CM; - view fewer (2016) Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. Acta Neuropathologica Communications , 4 , Article 66. 10.1186/s40478-016-0334-3.

Lee, ARA; Harvey, E; Sreenan, N; Rossoni, S; Powell, M; Woodcock, A; (2016) Editor's Note. Tropos , 3 (1) pp. 3-4.

Motamedi-Shad, N; Jagger, AM; Liedtke, M; Faull, SV; Nanda, AS; Salvadori, E; Wort, JL; ... Lomas, DA; + view all Motamedi-Shad, N; Jagger, AM; Liedtke, M; Faull, SV; Nanda, AS; Salvadori, E; Wort, JL; Kay, CW; Heyer-Chauhan, N; Miranda, E; Perez, J; Ordóñez, A; Haq, I; Irving, JA; Lomas, DA; - view fewer (2016) An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour. Biochemical Journal , 473 (19) pp. 3269-3290. 10.1042/BCJ20160159.

Roe, JK; Thomas, N; Gil, E; Best, K; Tsaliki, E; Morris-Jones, S; Stafford, S; ... Noursadeghi, M; + view all Roe, JK; Thomas, N; Gil, E; Best, K; Tsaliki, E; Morris-Jones, S; Stafford, S; Simpson, N; Witt, KD; Chain, B; Miller, RF; Martineau, A; Noursadeghi, M; - view fewer (2016) Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis. JCI Insight , 1 (16) , Article e87238. 10.1172/jci.insight.87238.

Roussel, BD; Lomas, DA; Crowther, DC; (2016) Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis). Epileptic Disorders , 18 (S2) pp. 103-110. 10.1684/epd.2016.0847.

Sevastou, I; Pryce, G; Baker, D; Selwood, DL; (2016) Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing. PLoS ONE , 11 (6) , Article e0157754. 10.1371/journal.pone.0157754.

Tabberer, M; Gonzalez-McQuire, S; Muellerova, H; Briggs, A; Rutten-van Molken, M; Chambers, M; Lomas, DA; (2016) Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease. Med Decis Making 10.1177/0272989X16662009. (In press).

2015

Guzman, JD; Pesnot, T; Barrera, DA; Davies, HM; McMahon, E; Evangelopoulos, D; Mortazavi, PN; ... Bhakta, S; + view all Guzman, JD; Pesnot, T; Barrera, DA; Davies, HM; McMahon, E; Evangelopoulos, D; Mortazavi, PN; Munshi, T; Maitra, A; Lamming, ED; Angell, R; Gershater, MC; Redmond, JM; Needham, D; Ward, JM; Cuca, LE; Hailes, HC; Bhakta, S; - view fewer (2015) Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. J Antimicrob Chemother , 70 (6) pp. 1691-1703. 10.1093/jac/dkv010.

Hull, EA; (2015) Antibody Conjugates via Disulfide Bridging: Towards therapeutic and diagnostic applications. Doctoral thesis , UCL (University College London).

Irving, JA; Miranda, E; Haq, I; Perez, J; Kotov, VR; Faull, SV; Motamedi-Shad, N; Irving, JA; Miranda, E; Haq, I; Perez, J; Kotov, VR; Faull, SV; Motamedi-Shad, N; Lomas, DA; - view fewer (2015) An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. Biochem J , 468 (1) pp. 99-108. 10.1042/BJ20141569.

Nyon, MP; Prentice, T; Day, J; Kirkpatrick, J; Sivalingam, GN; Levy, G; Haq, I; ... Thalassinos, K; + view all Nyon, MP; Prentice, T; Day, J; Kirkpatrick, J; Sivalingam, GN; Levy, G; Haq, I; Irving, JA; Lomas, DA; Christodoulou, J; Gooptu, B; Thalassinos, K; - view fewer (2015) An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding. Protein Science , 24 (8) pp. 1301-1312. 10.1002/pro.2706.

Partington, L; (2015) Development of a pressurised transmural decellularisation method for application in tissue engineering trachea. Doctoral thesis , UCL (University College London).

Tan, L; Perez, J; Mela, M; Miranda, E; Burling, KA; Rouhani, FN; DeMeo, DL; ... Lomas, DA; + view all Tan, L; Perez, J; Mela, M; Miranda, E; Burling, KA; Rouhani, FN; DeMeo, DL; Haq, I; Irving, JA; Ordóñez, A; Dickens, JA; Brantly, M; Marciniak, SJ; Alexander, GJ; Gooptu, B; Lomas, DA; - view fewer (2015) Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody. Int J Biochem Cell Biol , 58 81 - 91. 10.1016/j.biocel.2014.11.005.

2014

Broome, AH; Nabugodi, M; Sreenan, N; Harvey, L; (2014) Editor's note. Tropos , 2 (1) pp. 2-3. 10.14324/111.2057-2212.001.

Goodwin, GB; (2014) The double movement in the Andes: land reform, land markets, and indigenous mobilisation in Highland Ecuador (1964-1994). Doctoral thesis , UCL (University College London).

Irving, JA; Haq, I; Dickens, JA; Faull, SV; Lomas, DA; (2014) Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerisation. Biochem J , 460 (1) pp. 103-115. 10.1042/BJ20131650.

2013

Haq, I; Irving, JA; Faull, SV; Dickens, JA; Ordóñez, A; Belorgey, D; Gooptu, B; Haq, I; Irving, JA; Faull, SV; Dickens, JA; Ordóñez, A; Belorgey, D; Gooptu, B; Lomas, DA; - view fewer (2013) Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway. Bioscience Reports , 33 (3) , Article e00046. 10.1042/BSR20130038.

Kruppa, AJ; Ott, S; Chandraratna, DS; Irving, JA; Page, RM; Speretta, E; Seto, T; ... Crowther, DC; + view all Kruppa, AJ; Ott, S; Chandraratna, DS; Irving, JA; Page, RM; Speretta, E; Seto, T; Camargo, LM; Marciniak, SJ; Lomas, DA; Crowther, DC; - view fewer (2013) Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , 1832 (12) 2115 - 2126. 10.1016/j.bbadis.2013.07.019.

Ordóñez, A; Snapp, EL; Tan, L; Miranda, E; Marciniak, SJ; Lomas, DA; (2013) Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency. Hepatology , 57 (5) 2049 - 2060. 10.1002/hep.26173.

Roussel, BD; Newton, TM; Malzer, E; Simecek, N; Haq, I; Thomas, SE; Burr, ML; ... Lomas, DA; + view all Roussel, BD; Newton, TM; Malzer, E; Simecek, N; Haq, I; Thomas, SE; Burr, ML; Lehner, PJ; Crowther, DC; Marciniak, SJ; Lomas, DA; - view fewer (2013) Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB. Hum Mol Genet , 22 (22) pp. 4616-4626. 10.1093/hmg/ddt310.

Suvarna, SH; (2013) A clinical study of the neuropsychological outcome comparing Cardioplegic arrest Versus Intermittent cross-clamp fibrillation as myocardial protection techniques in coronary artery bypass grafting surgery. Doctoral thesis (PhD), UCL (University College London).

2012

Agustí, A; Edwards, LD; Rennard, SI; MacNee, W; Tal-Singer, R; Miller, BE; Vestbo, J; ... Evaluation of COPD Longitudinally to Identify Predictive Surroga; + view all Agustí, A; Edwards, LD; Rennard, SI; MacNee, W; Tal-Singer, R; Miller, BE; Vestbo, J; Lomas, DA; Calverley, PM; Wouters, E; Crim, C; Yates, JC; Silverman, EK; Coxson, HO; Bakke, P; Mayer, RJ; Celli, B; Evaluation of COPD Longitudinally to Identify Predictive Surroga; - view fewer (2012) Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One , 7 (5) , Article e37483. 10.1371/journal.pone.0037483.

ENOMOTO, K; (2012) Psychological factors associated with pain 24 hours post-tooth extraction. Doctoral thesis , UCL (University College London).

Nyon, MP; Segu, L; Cabrita, LD; Lévy, GR; Kirkpatrick, J; Roussel, BD; Patschull, AO; ... Gooptu, B; + view all Nyon, MP; Segu, L; Cabrita, LD; Lévy, GR; Kirkpatrick, J; Roussel, BD; Patschull, AO; Barrett, TE; Ekeowa, UI; Kerr, R; Waudby, CA; Kalsheker, N; Hill, M; Thalassinos, K; Lomas, DA; Christodoulou, J; Gooptu, B; - view fewer (2012) Structural dynamics associated with intermediate formation in an archetypal conformational disease. Structure , 20 (3) pp. 504-512. 10.1016/j.str.2012.01.012.

2011

Qiu, W; Cho, MH; Riley, JH; Anderson, WH; Singh, D; Bakke, P; Gulsvik, A; ... ECLIPSE Investigators; + view all Qiu, W; Cho, MH; Riley, JH; Anderson, WH; Singh, D; Bakke, P; Gulsvik, A; Litonjua, AA; Lomas, DA; Crapo, JD; Beaty, TH; Celli, BR; Rennard, S; Tal-Singer, R; Fox, SM; Silverman, EK; Hersh, CP; ECLIPSE Investigators; - view fewer (2011) Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One , 6 (9) , Article e24395. 10.1371/journal.pone.0024395.

2010

Chow, PS; (2010) Losing Control: Lars von Trier and the Production of Authenticity and the Auteur. Masters thesis , National University of Singapore.

Luheshi, LM; Hoyer, W; de Barros, TP; van Dijk Härd, I; Brorsson, AC; Macao, B; Persson, C; ... Härd, T; + view all Luheshi, LM; Hoyer, W; de Barros, TP; van Dijk Härd, I; Brorsson, AC; Macao, B; Persson, C; Crowther, DC; Lomas, DA; Ståhl, S; Dobson, CM; Härd, T; - view fewer (2010) Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo. PLoS Biology , 8 (3) , Article e1000334. 10.1371/journal.pbio.1000334.

2009

Nachat, R; Cipolat, S; Sevilla, LM; Chhatriwala, M; Groot, KR; Watt, FM; (2009) KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. Journal of Cell Science , 122 (22) pp. 4035-4041. 10.1242/jcs.047266.

Pillai, SG; Ge, D; Zhu, G; Kong, X; Shianna, KV; Need, AC; Feng, S; ... ICGN Investigators; + view all Pillai, SG; Ge, D; Zhu, G; Kong, X; Shianna, KV; Need, AC; Feng, S; Hersh, CP; Bakke, P; Gulsvik, A; Ruppert, A; Lødrup Carlsen, KC; Roses, A; Anderson, W; Rennard, SI; Lomas, DA; Silverman, EK; Goldstein, DB; ICGN Investigators; - view fewer (2009) A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet , 5 (3) e1000421. 10.1371/journal.pgen.1000421.

2007

Andoniadou, CL; Signore, M; Sajedi, E; Gaston-Massuet, C; Kelberman, D; Burns, AJ; Itasaki, N; ... Martinez-Barbera, JP; + view all Andoniadou, CL; Signore, M; Sajedi, E; Gaston-Massuet, C; Kelberman, D; Burns, AJ; Itasaki, N; Dattani, M; Martinez-Barbera, JP; - view fewer (2007) Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. DEVELOPMENT , 134 (8) 1499 - 1508. 10.1242/dev.02829.

Kerr, JR; Christian, P; Hodgetts, A; Langford, PR; D Devanur, L; Petty, R; Burke, B; ... Clinical Study Grp; + view all Kerr, JR; Christian, P; Hodgetts, A; Langford, PR; D Devanur, L; Petty, R; Burke, B; Sinclair, LI; Richards, SCM; Montgomery, J; McDermott, CR; Harrison, TJ; Kellam, P; Nutt, DJ; Holgate, ST; Clinical Study Grp; - view fewer (2007) Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments. J CLIN PATHOL , 60 (2) 113 - 116. 10.1136/jcp.2006.042374.

Luheshi, LM; Tartaglia, GG; Brorsson, AC; Pawar, AP; Watson, IE; Chiti, F; Vendruscolo, M; ... Crowther, DC; + view all Luheshi, LM; Tartaglia, GG; Brorsson, AC; Pawar, AP; Watson, IE; Chiti, F; Vendruscolo, M; Lomas, DA; Dobson, CM; Crowther, DC; - view fewer (2007) Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biology , 5 (11) , Article e290. 10.1371/journal.pbio.0050290.

2006

Omar, RZ; McNally, N; Ambler, G; Pollock, AM; (2006) Quality research in healthcare: are researchers getting enough statistical support? BMC Health Services Research , 6 , Article 2. 10.1186/1472-6963-6-2.

2002

Bellingan, GJ; Xu, P; Cooksley, H; Cauldwell, H; Shock, A; Bottoms, S; Haslett, C; ... Laurent, GJ; + view all Bellingan, GJ; Xu, P; Cooksley, H; Cauldwell, H; Shock, A; Bottoms, S; Haslett, C; Mutsaers, SE; Laurent, GJ; - view fewer (2002) Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J EXP MED , 196 (11) 1515 - 1521. 10.1084/jem.20011794.

1992

Flynn, MD; Beasley, P; Tooke, JE; (1992) Adrenal suppression with intranasal betamethasone drops. Journal of Laryngology and Otology , 106 (9) 827 - 828. 10.1017/S0022215100120997.

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